Robert M. Califf, MD


Professor of Medicine
Department / Division:
Medicine / Medicine - Cardiology
Address:
DUMC 3701
Durham, NC 27710

200 Trent Drive, 1117 Davison Building
Durham, NC 27710
Appointment Telephone:
919-681-5816
Office Telephone:
919-668-8820
Fax:
919-668-7103
Training:
  • MD, Duke University School of Medicine, 1978
Residency:
  • Medicine, University of California–San Francisco Medical Center, 1979-1980
  • Cardiology, Duke University Medical Center, 1980-1983
Clinical Interests:
Chronic coronary artery disease; heart failure; acute coronary syndromes
Research Interests:
Dr. Califf is currently on leave from Duke University.
Representative Publications:
  • DeMets, DL; Califf, RM. A historical perspective on clinical trials innovation and leadership: where have the academics gone?. JAMA : the journal of the American Medical Association. 2011;305:713-714.  Abstract
  • Vamadevan, AS; Shah, BR; Califf, RM; Prabhakaran, D. Cardiovascular research in India: a perspective. American Heart Journal. 2011;161:431-438.  Abstract
  • Zarin, DA; Tse, T; Williams, RJ; Califf, RM; Ide, NC. The ClinicalTrials.gov results database--update and key issues. The New England journal of medicine. 2011;364:852-860.  Abstract
  • Califf, RM; Armstrong, PW; Granger, CB; Harrington, RA; Lee, K; Simes, RJ; Van de Werf, F; Wallentin, L; White, HD; Virtual Coordinating Centre for Global Collaborative Cardiovascular Research Organization. Towards a new order in cardiovascular medicine: re-engineering through global collaboration. European Heart Journal (Elsevier). 2010;31:911-917.  Abstract
  • Califf, RM; Berglund, L; Principal Investigators of National Institutes of Health Clinical and Translational Science Awards. Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards. Academic Medicine. 2010;85:457-462.  Abstract
  • Dzau, VJ; Ackerly, DC; Sutton-Wallace, P; Merson, MH; Williams, RS; Krishnan, KR; Taber, RC; Califf, RM. The role of academic health science systems in the transformation of medicine. The Lancet. 2010;375:949-953.  Abstract
  • Harrington, RA; Califf, RM. There is a role for industry-sponsored education in cardiology. Circulation. 2010;121:2221-2227.  Abstract
  • NAVIGATOR Study Group, ; Holman, RR; Haffner, SM; McMurray, JJ; Bethel, MA; Holzhauer, B; Hua, TA; Belenkov, Y; Boolell, M; Buse, JB; Buckley, BM; Chacra, AR; Chiang, FT; Charbonnel, B; Chow, CC; Davies, MJ; Deedwania, P; Diem, P; Einhorn, D; Fonseca, V; Fulcher, GR; Gaciong, Z; Gaztambide, S; Giles, T; Horton, E; Ilkova, H; Jenssen, T; Kahn, SE; Krum, H; Laakso, M; Leiter, LA; Levitt, NS; Mareev, V; Martinez, F; Masson, C; Mazzone, T; Meaney, E; Nesto, R; Pan, C; Prager, R; Raptis, SA; Rutten, GE; Sandstroem, H; Schaper, F; Scheen, A; Schmitz, O; Sinay, I; Soska, V; Stender, S; Tamás, G; Tognoni, G; Tuomilehto, J; Villamil, AS; Vozár, J; Califf, RM. Effect of nateglinide on the incidence of diabetes and cardiovascular events. The New England journal of medicine. 2010;362:1463-1476.  Abstract
  • NAVIGATOR Study Group, ; McMurray, JJ; Holman, RR; Haffner, SM; Bethel, MA; Holzhauer, B; Hua, TA; Belenkov, Y; Boolell, M; Buse, JB; Buckley, BM; Chacra, AR; Chiang, FT; Charbonnel, B; Chow, CC; Davies, MJ; Deedwania, P; Diem, P; Einhorn, D; Fonseca, V; Fulcher, GR; Gaciong, Z; Gaztambide, S; Giles, T; Horton, E; Ilkova, H; Jenssen, T; Kahn, SE; Krum, H; Laakso, M; Leiter, LA; Levitt, NS; Mareev, V; Martinez, F; Masson, C; Mazzone, T; Meaney, E; Nesto, R; Pan, C; Prager, R; Raptis, SA; Rutten, GE; Sandstroem, H; Schaper, F; Scheen, A; Schmitz, O; Sinay, I; Soska, V; Stender, S; Tamás, G; Tognoni, G; Tuomilehto, J; Villamil, AS; Vozár, J; Califf, RM. Effect of valsartan on the incidence of diabetes and cardiovascular events. The New England journal of medicine. 2010;362:1477-1490.  Abstract
  • Califf, RM. A virtuous cycle to improve hypertension outcomes at a national level: linking public health and individualized medicine. Hypertension. 2009;53:105-107.  Abstract
  • Califf, RM. Clinical research sites--the underappreciated component of the clinical research system. JAMA : the journal of the American Medical Association. 2009;302:2025-2027.  Abstract
  • Califf, RM. Rational use of medications: if Canada can't do it ... CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2009;181:15-16.  Abstract
  • Califf, RM; Harrington, RA; Blazing, MA. Premature release of data from clinical trials of ezetimibe. The New England journal of medicine. 2009;361:712-717.  Abstract
  • Califf, RM; Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (VIGOUR) organisation. Key issues for global cardiovascular medicine. The Lancet. 2009;374:508-510.  Abstract
  • Coller, BS; Califf, RM. Traversing the valley of death: a guide to assessing prospects for translational success. Science Translational Medicine. 2009;1:10cm9.  Abstract
  • Al-Khatib, SM; Sanders, GD; Bigger, JT; Buxton, AE; Califf, RM; Carlson, M; Curtis, A; Curtis, J; Fain, E; Gersh, BJ; Gold, MR; Haghighi-Mood, A; Hammill, SC; Healey, J; Hlatky, M; Hohnloser, S; Kim, RJ; Lee, K; Mark, D; Mianulli, M; Mitchell, B; Prystowsky, EN; Smith, J; Steinhaus, D; Zareba, W; Expert panel participating in a Duke's Center for the Prevention of Sudden Cardiac Death conference. Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death. American Heart Journal. 2007;153:941-950.  Abstract
  • Al-Khatib, SM; Shaw, LK; O'Connor, C; Kong, M; Califf, RM. Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. Journal of Cardiovascular Electrophysiology. 2007;18:1231-1235.  Abstract
  • Anderson, JL; Adams, CD; Antman, EM; Bridges, CR; Califf, RM; Casey, DE; Chavey, WE; Fesmire, FM; Hochman, JS; Levin, TN; Lincoff, AM; Peterson, ED; Theroux, P; Wenger, NK; Wright, RS; Smith, SC; Jacobs, AK; Adams, CD; Anderson, JL; Antman, EM; Halperin, JL; Hunt, SA; Krumholz, HM; Kushner, FG; Lytle, BW; Nishimura, R; Ornato, JP; Page, RL; Riegel, B; American College of Cardiology, ; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction), ; American College of Emergency Physicians, ; Society for Cardiovascular Angiography and Interventions, ; Society of Thoracic Surgeons, ; American Association of Cardiovascular and Pulmonary Rehabilitation, ; . . . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Journal of the American College of Cardiology. 2007;50:e1-e157.  Abstract
  • Anderson, JL; Adams, CD; Antman, EM; Bridges, CR; Califf, RM; Casey, DE; Chavey, WE; Fesmire, FM; Hochman, JS; Levin, TN; Lincoff, AM; Peterson, ED; Theroux, P; Wenger, NK; Wright, RS; Smith, SC; Jacobs, AK; Halperin, JL; Hunt, SA; Krumholz, HM; Kushner, FG; Lytle, BW; Nishimura, R; Ornato, JP; Page, RL; Riegel, B; American College of Cardiology, ; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction), ; American College of Emergency Physicians, ; Society for Cardiovascular Angiography and Interventions, ; Society of Thoracic Surgeons, ; American Association of Cardiovascular and Pulmonary Rehabilitation, ; Society for Academic Emergency Medici. . . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 2007;116:e148-e304.  Abstract
  • Barbagelata, A; Perna, ER; Clemmensen, P; Uretsky, BF; Canella, JP; Califf, RM; Granger, CB; Adams, GL; Merla, R; Birnbaum, Y. Time to reperfusion in acute myocardial infarction. It is time to reduce it!. Journal of Electrocardiology. 2007;40:257-264.  Abstract
  • Bennett-Guerrero, E; Veldman, TH; Doctor, A; Telen, MJ; Ortel, TL; Reid, TS; Mulherin, MA; Zhu, H; Buck, RD; Califf, RM; McMahon, TJ. Evolution of adverse changes in stored RBCs. Proceedings of the National Academy of Sciences of USA. 2007;104:17063-17068.  Abstract
  • Califf, RM; CERTs Benefit Assessment Workshop Participants. Benefit assessment of therapeutic products: the Centers for Education and Research on Therapeutics. Pharmacoepidemiology and Drug Safety. 2007;16:5-16.  Abstract
  • Califf, RM; Harrington, RA; Madre, LK; Peterson, ED; Roth, D; Schulman, KA. Curbing the cardiovascular disease epidemic: aligning industry, government, payers, and academics. Health Affairs. 2007;26:62-74.  Abstract
  • Califf, RM; Mehta, RH; Peterson, ED. Clinical quality in non-ST-elevation acute coronary syndromes. American Journal of Medicine. 2007;120:930-935.  Abstract
  • Echols, MR; Mahaffey, KW; Banerjee, A; Pieper, KS; Stebbins, A; Lansky, A; Cohen, MG; Velazquez, E; Santos, R; Newby, LK; Gurfinkel, EP; Biasucci, L; Ferguson, JJ; Califf, RM. Racial differences among high-risk patients presenting with non-ST-segment elevation acute coronary syndromes (results from the SYNERGY trial). The American Journal of Cardiology. 2007;99:315-321.  Abstract
  • Eisenstein, EL; Anstrom, KJ; Kong, DF; Shaw, LK; Tuttle, RH; Mark, DB; Kramer, JM; Harrington, RA; Matchar, DB; Kandzari, DE; Peterson, ED; Schulman, KA; Califf, RM. Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA : the journal of the American Medical Association. 2007;297:159-168.  Abstract
  • Goyal, A; Alexander, JH; Hafley, GE; Graham, SH; Mehta, RH; Mack, MJ; Wolf, RK; Cohn, LH; Kouchoukos, NT; Harrington, RA; Gennevois, D; Gibson, CM; Califf, RM; Ferguson, TB; Peterson, ED; PREVENT IV Investigators. Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery. Annals of Thoracic Surgery. 2007;83:993-1001.  Abstract
  • Hasselblad, V; Gattis Stough, W; Shah, MR; Lokhnygina, Y; O'Connor, CM; Califf, RM; Adams, KF. Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. European Journal of Heart Failure (Elsevier). 2007;9:1064-1069.  Abstract
  • Hernández, AV; Westerhout, CM; Steyerberg, EW; Ioannidis, JP; Bueno, H; White, H; Theroux, P; Moliterno, DJ; Armstrong, PW; Califf, RM; Wallentin, LC; Simoons, ML; Boersma, E. Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST segment elevation acute coronary syndromes: benefit and harm in different age subgroups. Heart. 2007;93:450-455.  Abstract
  • Jiang, W; Kuchibhatla, M; Clary, GL; Cuffe, MS; Christopher, EJ; Alexander, JD; Califf, RM; Krishnan, RR; O'Connor, CM. Relationship between depressive symptoms and long-term mortality in patients with heart failure. American Heart Journal. 2007;154:102-108.  Abstract
  • Li, JS; Eisenstein, EL; Grabowski, HG; Reid, ED; Mangum, B; Schulman, KA; Goldsmith, JV; Murphy, MD; Califf, RM; Benjamin, DK. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA : the journal of the American Medical Association. 2007;297:480-488.  Abstract
  • Li, JS; Yow, E; Berezny, KY; Rhodes, JF; Bokesch, PM; Charpie, JR; Forbus, GA; Mahony, L; Boshkov, L; Lambert, V; Bonnet, D; Michel-Behnke, I; Graham, TP; Takahashi, M; Jaggers, J; Califf, RM; Rakhit, A; Fontecave, S; Sanders, SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?. Circulation. 2007;116:293-297.  Abstract
  • Mahaffey, KW; Roe, MT; Kilaru, R; Alexander, JH; Van de Werf, F; Califf, RM; Simoons, ML; Topol, EJ; Harrington, RA. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. European Heart Journal (Elsevier). 2007;28:425-432.  Abstract
  • Mark, DB; Van de Werf, FJ; Simes, RJ; White, HD; Wallentin, LC; Califf, RM; Armstrong, PW; VIGOUR Group. Cardiovascular disease on a global scale: defining the path forward for research and practice. European Heart Journal (Elsevier). 2007;28:2678-2684.  Abstract
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