Robert M. Califf, MD


Professor of Medicine
Director, Duke Translational Medicine Institute
Vice Chancellor for Clinical and Translational Research
Department / Division:
Medicine / Medicine - Cardiology
Address:
DUMC 3701
Durham, NC 27710

200 Trent Drive, 1117 Davison Building
Durham, NC 27710
Appointment Telephone:
919-681-5816
Office Telephone:
919-668-8820
Fax:
919-668-7103
Training:
  • MD, Duke University School of Medicine, 1978
Residency:
  • Medicine, University of California–San Francisco Medical Center, 1979-1980
  • Cardiology, Duke University Medical Center, 1980-1983
Clinical Interests:
Chronic coronary artery disease; heart failure; acute coronary syndromes
Research Interests:

Robert M. Califf, MD, MACC, is the Donald F. Fortin, MD, Professor of Cardiology at the Duke University School of Medicine, Vice Chancellor for Clinical and Translational Research, and director of the Duke Translational Medicine Institute (DTMI), Duke University’s academic home for clinical and translational research.

Born in 1951 in Anderson, South Carolina, Dr. Califf attended high school in Columbia, where he was a member of the 1969 AAAA South Carolina Championship basketball team. He attended Duke University, graduating in 1973 summa cum laude and Phi Beta Kappa. In 1978, he graduated from the Duke University School of Medicine, where he was inducted into the Alpha Omega Alpha medical honor society. After completing an internal medicine residency at the University of California, San Francisco, he returned to Duke to complete a fellowship in cardiology. He is board-certified in internal medicine (1984) and cardiology (1986), and is a Master of the American College of Cardiology (2006).

Prior to his current role as DTMI director, Dr. Califf served as the founding director of the Duke Clinical Research Institute (DCRI), one of the world’s largest academic clinical research organizations. He is the author or coauthor of more than 1,100 peer-reviewed articles, reviews, and editorials and is among the most frequently cited authors in medicine. Dr. Califf is the editor-in-chief of the American Heart Journal and has served on the FDA’s Cardiorenal Advisory Panel and on the Pharmaceutical Roundtable of the Institute of Medicine (IOM). He also served as founding director of the coordinating center for the Centers for Education & Research on Therapeutics™ (CERTs), a public-private partnership that seeks to advance and optimize the use of medical products.

Dr. Califf is currently a member of the IOM Forum in Drug Discovery, Development, and Translation and the IOM Policy Committee. Prior to this, he served on the IOM’s Committee on Identifying and Preventing Medication Errors and on committees that recommended Medicare coverage for clinical trials and the removal of ephedra from the market. He also co-chairs the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by Duke and the FDA, and chairs the Clinical Research Forum (CRF), an organization of academic health system leaders; both CTTI and the CRF are devoted to facilitating systemic improvements to the clinical research enterprise.

Dr. Califf is co-principal investigator of Duke’s Clinical and Translational Science Award, funded by the National Center for Advancing Translational Sciences, and of the Southeastern Diabetes Initiative, a Health Care Innovations Award from the Centers for Medicare and Medicaid Services that aims to reduce health inequities by using geospatial mapping to deploy population-level interventions. He is principal investigator for the coordinating center of the NIH Health Care Systems Research Collaboratory, a Common Fund program that develops, tests, and disseminates innovative methodologies for pragmatic clinical research. He is also a co-director of the coordinating center for the National Patient-Centered Clinical Research Network (PCORnet), a nationwide initiative that supports large-scale patient-centered trials and comparative effectiveness research, and is a co-principal investigator for the Baseline Study, a collaboration among Duke, Stanford, and Google that seeks new understandings of states of health and disease in humans. 

Dr. Califf is married to Lydia Carpenter Califf, and they have three children—Sharon Califf, a graduate of Elon College; Sam, a doctoral candidate in aerospace engineering at the University of Colorado-Boulder; and Tom, a medical student at the University of Colorado School of Medicine—and two grandchildren. Dr. Califf enjoys spending time with his family, working o

Representative Publications:
  • DeMets, DL; Califf, RM. A historical perspective on clinical trials innovation and leadership: where have the academics gone?. JAMA: Journal of the American Medical Association. 2011;305:713-714.  Abstract
  • Vamadevan, AS; Shah, BR; Califf, RM; Prabhakaran, D. Cardiovascular research in India: a perspective. American Heart Journal. 2011;161:431-438.  Abstract
  • Zarin, DA; Tse, T; Williams, RJ; Califf, RM; Ide, NC. The ClinicalTrials.gov results database--update and key issues. New England Journal of Medicine. 2011;364:852-860.  Abstract
  • Califf, RM; Armstrong, PW; Granger, CB; Harrington, RA; Lee, K; Simes, RJ; Van de Werf, F; Wallentin, L; White, HD; Virtual Coordinating Centre for Global Collaborative Cardiovascular Research Organization. Towards a new order in cardiovascular medicine: re-engineering through global collaboration. European Heart Journal. 2010;31:911-917.  Abstract
  • Califf, RM; Berglund, L; Principal Investigators of National Institutes of Health Clinical and Translational Science Awards. Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards. Academic Medicine. 2010;85:457-462.  Abstract
  • Dzau, VJ; Ackerly, DC; Sutton-Wallace, P; Merson, MH; Williams, RS; Krishnan, KR; Taber, RC; Califf, RM. The role of academic health science systems in the transformation of medicine. Lancet. 2010;375:949-953.  Abstract
  • Harrington, RA; Califf, RM. There is a role for industry-sponsored education in cardiology. Circulation. 2010;121:2221-2227.  Abstract
  • NAVIGATOR Study Group, ; Holman, RR; Haffner, SM; McMurray, JJ; Bethel, MA; Holzhauer, B; Hua, TA; Belenkov, Y; Boolell, M; Buse, JB; Buckley, BM; Chacra, AR; Chiang, FT; Charbonnel, B; Chow, CC; Davies, MJ; Deedwania, P; Diem, P; Einhorn, D; Fonseca, V; Fulcher, GR; Gaciong, Z; Gaztambide, S; Giles, T; Horton, E; Ilkova, H; Jenssen, T; Kahn, SE; Krum, H; Laakso, M; Leiter, LA; Levitt, NS; Mareev, V; Martinez, F; Masson, C; Mazzone, T; Meaney, E; Nesto, R; Pan, C; Prager, R; Raptis, SA; Rutten, GE; Sandstroem, H; Schaper, F; Scheen, A; Schmitz, O; Sinay, I; Soska, V; Stender, S; Tamás, G; Tognoni, G; Tuomilehto, J; Villamil, AS; Vozár, J; Califf, RM. Effect of nateglinide on the incidence of diabetes and cardiovascular events. New England Journal of Medicine. 2010;362:1463-1476.  Abstract
  • NAVIGATOR Study Group, ; McMurray, JJ; Holman, RR; Haffner, SM; Bethel, MA; Holzhauer, B; Hua, TA; Belenkov, Y; Boolell, M; Buse, JB; Buckley, BM; Chacra, AR; Chiang, FT; Charbonnel, B; Chow, CC; Davies, MJ; Deedwania, P; Diem, P; Einhorn, D; Fonseca, V; Fulcher, GR; Gaciong, Z; Gaztambide, S; Giles, T; Horton, E; Ilkova, H; Jenssen, T; Kahn, SE; Krum, H; Laakso, M; Leiter, LA; Levitt, NS; Mareev, V; Martinez, F; Masson, C; Mazzone, T; Meaney, E; Nesto, R; Pan, C; Prager, R; Raptis, SA; Rutten, GE; Sandstroem, H; Schaper, F; Scheen, A; Schmitz, O; Sinay, I; Soska, V; Stender, S; Tamás, G; Tognoni, G; Tuomilehto, J; Villamil, AS; Vozár, J; Califf, RM. Effect of valsartan on the incidence of diabetes and cardiovascular events. New England Journal of Medicine. 2010;362:1477-1490.  Abstract
  • Califf, RM. A virtuous cycle to improve hypertension outcomes at a national level: linking public health and individualized medicine. Hypertension. 2009;53:105-107.  Abstract
  • Califf, RM. Clinical research sites--the underappreciated component of the clinical research system. JAMA: Journal of the American Medical Association. 2009;302:2025-2027.  Abstract
  • Califf, RM. Rational use of medications: if Canada can't do it ... CMAJ. 2009;181:15-16.  Abstract
  • Califf, RM; Harrington, RA; Blazing, MA. Premature release of data from clinical trials of ezetimibe. New England Journal of Medicine. 2009;361:712-717.  Abstract
  • Califf, RM; Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (VIGOUR) organisation. Key issues for global cardiovascular medicine. Lancet. 2009;374:508-510.  Abstract
  • Coller, BS; Califf, RM. Traversing the valley of death: a guide to assessing prospects for translational success. Science Translational Medicine. 2009;1:10cm9.  Abstract
  • Al-Khatib, SM; Sanders, GD; Bigger, JT; Buxton, AE; Califf, RM; Carlson, M; Curtis, A; Curtis, J; Fain, E; Gersh, BJ; Gold, MR; Haghighi-Mood, A; Hammill, SC; Healey, J; Hlatky, M; Hohnloser, S; Kim, RJ; Lee, K; Mark, D; Mianulli, M; Mitchell, B; Prystowsky, EN; Smith, J; Steinhaus, D; Zareba, W; Expert panel participating in a Duke's Center for the Prevention of Sudden Cardiac Death conference. Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death. American Heart Journal. 2007;153:941-950.  Abstract
  • Al-Khatib, SM; Shaw, LK; O'Connor, C; Kong, M; Califf, RM. Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. Journal of Cardiovascular Electrophysiology. 2007;18:1231-1235.  Abstract
  • Anderson, JL; Adams, CD; Antman, EM; Bridges, CR; Califf, RM; Casey, DE; Chavey, WE; Fesmire, FM; Hochman, JS; Levin, TN; Lincoff, AM; Peterson, ED; Theroux, P; Wenger, NK; Wright, RS; Smith, SC; Jacobs, AK; Adams, CD; Anderson, JL; Antman, EM; Halperin, JL; Hunt, SA; Krumholz, HM; Kushner, FG; Lytle, BW; Nishimura, R; Ornato, JP; Page, RL; Riegel, B; American College of Cardiology, ; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction), ; American College of Emergency Physicians, ; Society for Cardiovascular Angiography and Interventions, ; Society of Thoracic Surgeons, ; American Association of Cardiovascular and Pulmonary Rehabilitation, ; . . . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Journal of the American College of Cardiology. 2007;50:e1-e157.  Abstract
  • Anderson, JL; Adams, CD; Antman, EM; Bridges, CR; Califf, RM; Casey, DE; Chavey, WE; Fesmire, FM; Hochman, JS; Levin, TN; Lincoff, AM; Peterson, ED; Theroux, P; Wenger, NK; Wright, RS; Smith, SC; Jacobs, AK; Halperin, JL; Hunt, SA; Krumholz, HM; Kushner, FG; Lytle, BW; Nishimura, R; Ornato, JP; Page, RL; Riegel, B; American College of Cardiology, ; American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction), ; American College of Emergency Physicians, ; Society for Cardiovascular Angiography and Interventions, ; Society of Thoracic Surgeons, ; American Association of Cardiovascular and Pulmonary Rehabilitation, ; Society for Academic Emergency Medici. . . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 2007;116:e148-e304.  Abstract
  • Barbagelata, A; Perna, ER; Clemmensen, P; Uretsky, BF; Canella, JP; Califf, RM; Granger, CB; Adams, GL; Merla, R; Birnbaum, Y. Time to reperfusion in acute myocardial infarction. It is time to reduce it!. Journal of Electrocardiology. 2007;40:257-264.  Abstract
  • Bennett-Guerrero, E; Veldman, TH; Doctor, A; Telen, MJ; Ortel, TL; Reid, TS; Mulherin, MA; Zhu, H; Buck, RD; Califf, RM; McMahon, TJ. Evolution of adverse changes in stored RBCs. Proceedings of the National Academy of Sciences of USA. 2007;104:17063-17068.  Abstract
  • Califf, RM; CERTs Benefit Assessment Workshop Participants. Benefit assessment of therapeutic products: the Centers for Education and Research on Therapeutics. Pharmacoepidemiology and Drug Safety. 2007;16:5-16.  Abstract
  • Califf, RM; Harrington, RA; Madre, LK; Peterson, ED; Roth, D; Schulman, KA. Curbing the cardiovascular disease epidemic: aligning industry, government, payers, and academics. Health Affairs. 2007;26:62-74.  Abstract
  • Califf, RM; Mehta, RH; Peterson, ED. Clinical quality in non-ST-elevation acute coronary syndromes. American Journal of Medicine. 2007;120:930-935.  Abstract
  • Echols, MR; Mahaffey, KW; Banerjee, A; Pieper, KS; Stebbins, A; Lansky, A; Cohen, MG; Velazquez, E; Santos, R; Newby, LK; Gurfinkel, EP; Biasucci, L; Ferguson, JJ; Califf, RM. Racial differences among high-risk patients presenting with non-ST-segment elevation acute coronary syndromes (results from the SYNERGY trial). American Journal of Cardiology. 2007;99:315-321.  Abstract
  • Eisenstein, EL; Anstrom, KJ; Kong, DF; Shaw, LK; Tuttle, RH; Mark, DB; Kramer, JM; Harrington, RA; Matchar, DB; Kandzari, DE; Peterson, ED; Schulman, KA; Califf, RM. Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA: Journal of the American Medical Association. 2007;297:159-168.  Abstract
  • Goyal, A; Alexander, JH; Hafley, GE; Graham, SH; Mehta, RH; Mack, MJ; Wolf, RK; Cohn, LH; Kouchoukos, NT; Harrington, RA; Gennevois, D; Gibson, CM; Califf, RM; Ferguson, TB; Peterson, ED; PREVENT IV Investigators. Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery. Annals of Thoracic Surgery. 2007;83:993-1001.  Abstract
  • Hasselblad, V; Gattis Stough, W; Shah, MR; Lokhnygina, Y; O'Connor, CM; Califf, RM; Adams, KF. Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. European Journal of Heart Failure. 2007;9:1064-1069.  Abstract
  • Hernández, AV; Westerhout, CM; Steyerberg, EW; Ioannidis, JP; Bueno, H; White, H; Theroux, P; Moliterno, DJ; Armstrong, PW; Califf, RM; Wallentin, LC; Simoons, ML; Boersma, E. Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST segment elevation acute coronary syndromes: benefit and harm in different age subgroups. Heart. 2007;93:450-455.  Abstract
  • Jiang, W; Kuchibhatla, M; Clary, GL; Cuffe, MS; Christopher, EJ; Alexander, JD; Califf, RM; Krishnan, RR; O'Connor, CM. Relationship between depressive symptoms and long-term mortality in patients with heart failure. American Heart Journal. 2007;154:102-108.  Abstract
  • Li, JS; Eisenstein, EL; Grabowski, HG; Reid, ED; Mangum, B; Schulman, KA; Goldsmith, JV; Murphy, MD; Califf, RM; Benjamin, DK. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA: Journal of the American Medical Association. 2007;297:480-488.  Abstract
  • Li, JS; Yow, E; Berezny, KY; Rhodes, JF; Bokesch, PM; Charpie, JR; Forbus, GA; Mahony, L; Boshkov, L; Lambert, V; Bonnet, D; Michel-Behnke, I; Graham, TP; Takahashi, M; Jaggers, J; Califf, RM; Rakhit, A; Fontecave, S; Sanders, SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?. Circulation. 2007;116:293-297.  Abstract
  • Mahaffey, KW; Roe, MT; Kilaru, R; Alexander, JH; Van de Werf, F; Califf, RM; Simoons, ML; Topol, EJ; Harrington, RA. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. European Heart Journal. 2007;28:425-432.  Abstract
  • Mark, DB; Van de Werf, FJ; Simes, RJ; White, HD; Wallentin, LC; Califf, RM; Armstrong, PW; VIGOUR Group. Cardiovascular disease on a global scale: defining the path forward for research and practice. European Heart Journal. 2007;28:2678-2684.  Abstract
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