Nelson J. Chao, MD, MBA


Professor of Medicine
ResearchProfessor of Global Health
Professor in Immunology
Professor in Pathology
Chief, Division of Cellular Therapy
Department / Division:
Medicine / Medicine - Cell Therapy and Hematologica
Address:
DUMC 3961
Durham, NC 27710
Appointment Telephone:
919-668-1027
Office Telephone:
919-668-1002
Fax:
919-668-1091
Training:
  • MD, Yale University School of Medicine (Connecticut), 1981
Residency:
  • Medicine, Stanford University Medical Center (California), 1981-1984
  • Oncology, Stanford University Medical Center (California), 1985-1987
Other Training:
  • MBA, Duke University Fuqua School of Business, 2000
Clinical Interests:
Hematology, oncology, bone-marrow transplantation
Research Interests:
My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf
Representative Publications:
  • Chao, NJ; Liu, CX; Rooney, B; Chen, BJ; Long, GD; Vredenburgh, JJ; Morris, A; Gasparetto, C; Rizzieri, DA. Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells. Biology of Blood and Marrow Transplantation. 2002;8:249-256.  Abstract
  • Chen, BJ; Chen, Y; Cui, X; Fidler, JM; Chao, NJ. Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. Transplantation. 2002;73:115-121.  Abstract
  • Chen, BJ; Cui, X; Chao, NJ. Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation. Blood. 2002;99:2235-2240.  Abstract
  • Chen, BJ; Cui, X; Liu, C; Chao, NJ. Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. Blood. 2002;99:3083-3088.  Abstract
  • Chen, BJ; Cui, X; Sempowski, GD; Gooding, ME; Liu, C; Haynes, BF; Chao, NJ. A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. Blood. 2002;99:364-371.  Abstract
  • Gasparetto, C; Gasparetto, M; Morse, M; Rooney, B; Vredenburgh, JJ; Long, GD; Rizzieri, DA; Loftis, J; Chao, NJ; Smith, C. Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-Ligand and G-CSF or GM-CSF. Cytokine. 2002;18:8-19.  Abstract
  • McCune, SL; Gockerman, JP; Moore, JO; Decastro, CM; Bass, AJ; Chao, NJ; Long, GD; Vredenburgh, JJ; Gasparetto, C; Adams, D; Payne, N; Rizzieri, DA. Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia. Leukemia and Lymphoma. 2002;43:1007-1011.  Abstract
  • Morse, MA; Rizzieri, D; Stenzel, TT; Hobeika, AC; Vredenburgh, JJ; Chao, NJ; Clay, TM; Mosca, PJ; Lyerly, HK. Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants. Stem Cells and Development. 2002;11:659-668.  Abstract
  • Boeckh, M; Bowden, RA; Storer, B; Chao, NJ; Spielberger, R; Tierney, DK; Gallez-Hawkins, G; Cunningham, T; Blume, KG; Levitt, D; Zaia, JA. Randomized, placebo-controlled, double-blind study of a cytomegalovirus-specific monoclonal antibody (MSL-109) for prevention of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2001;7:343-351.  Abstract
  • Goker, H; Haznedaroglu, IC; Chao, NJ. Acute graft-vs-host disease: pathobiology and management. Experimental Hematology. 2001;29:259-277.  Abstract
  • Horning, SJ; Negrin, RS; Hoppe, RT; Rosenberg, SA; Chao, NJ; Long, GD; Brown, BW; Blume, KG. High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial. Blood. 2001;97:404-409.  Abstract
  • Klein, AK; Patel, DD; Gooding, ME; Sempowski, GD; Chen, BJ; Liu, C; Kurtzberg, J; Haynes, BF; Chao, NJ. T-Cell recovery in adults and children following umbilical cord blood transplantation. Biology of Blood and Marrow Transplantation. 2001;7:454-466.  Abstract
  • Rizzieri, DA; Long, GD; Vredenburgh, JJ; Gasparetto, C; Morris, A; Stenzel, TT; Davis, P; Chao, NJ. Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen. Blood. 2001;98:3486-3488.  Abstract
  • Alvarnas, JC; Negrin, RS; Horning, SJ; Hu, WW; Long, GD; Schriber, JR; Stockerl-Goldstein, K; Tierney, K; Wong, R; Blume, KG; Chao, NJ. High-dose therapy with hematopoietic cell transplantation for patients with central nervous system involvement by non-Hodgkin's lymphoma. Biology of Blood and Marrow Transplantation. 2000;6:352-358.  Abstract
  • Bhalla, KS; Wilczynski, SW; Abushamaa, AM; Petros, WP; McDonald, CS; Loftis, JS; Chao, NJ; Vredenburgh, JJ; Folz, RJ. Pulmonary toxicity of induction chemotherapy prior to standard or high-dose chemotherapy with autologous hematopoietic support. American Journal of Respiratory and Critical Care Medicine. 2000;161:17-25.  Abstract
  • Brodwater, BK; Silber, JS; Smith, TP; Chao, NJ; Suhocki, PV; Ryan, JM; Newman, GE. Conversion of indwelling chest port catheters to tunneled central venous catheters. Journal of Vascular and Interventional Radiology. 2000;11:1137-1142.  Abstract
  • Chao, NJ. Progress in graft-versus-host disease. Stem Cells and Development. 2000;9:295-296.  Abstract
  • Chao, NJ; Snyder, DS; Jain, M; Wong, RM; Niland, JC; Negrin, RS; Long, GD; Hu, WW; Stockerl-Goldstein, KE; Johnston, LJ; Amylon, MD; Tierney, DK; O'Donnell, MR; Nademanee, AP; Parker, P; Stein, A; Molina, A; Fung, H; Kashyap, A; Kohler, S; Spielberger, R; Krishnan, A; Rodriguez, R; Forman, SJ; Bluzme, KG. Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: results of a prospective double-blind randomized trial. Biology of Blood and Marrow Transplantation. 2000;6:254-261.  Abstract
  • Chen, BJ; Liu, C; Cui, X; Fidler, JM; Chao, NJ. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000;70:1442-1447.  Abstract
  • Chen, BJ; Morris, RE; Chao, NJ. Graft-versus-host disease prevention by rapamycin: cellular mechanisms. Biology of Blood and Marrow Transplantation. 2000;6:529-536.  Abstract
  • Chen, Y; Zeng, D; Schlegel, PG; Fidler, J; Chao, NJ. PG27, an extract of Tripterygium wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation in mice. Blood. 2000;95:705-710.  Abstract
  • Hu, WW; Negrin, RS; Stockerl-Goldstein, K; Johnston, LJ; Shizuru, JA; Wong, RM; Chao, NJ; Long, GD; Feiner, RH; Blume, KG. Four-cycle high-dose therapy with hematopoietic support for metastatic breast cancer: no improvement in outcomes compared with single-course high-dose therapy. Biology of Blood and Marrow Transplantation. 2000;6:58-69.  Abstract
  • Shbarou, RM; Chao, NJ; Morgenlander, JC. Cyclosporin A-related cerebral vasculopathy. Bone Marrow Transplantation. 2000;26:801-804.  Abstract
  • Ferrara, JL; Levy, R; Chao, NJ. Pathophysiologic mechanisms of acute graft-vs.-host disease. Biology of Blood and Marrow Transplantation. 1999;5:347-356.  Abstract
  • Hu, WW; Long, GD; Stockerl-Goldstein, KE; Johnston, LJ; Chao, NJ; Negrin, RS; Blume, KG. A feasibility study of multiple cycle therapy with melphalan, thiotepa, and paclitaxel followed by mitoxantrone, thiotepa, and paclitaxel with autologous hematopoietic cell support for metastatic breast cancer. Clinical Cancer Research. 1999;5:3411-3418.  Abstract
  • Nieto, Y; Cagnoni, PJ; Shpall, EJ; Xu, X; Murphy, J; Vredenburgh, J; Chao, NJ; Bearman, SI; Jones, RB. A predictive model for relapse in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplant. Clinical Cancer Research. 1999;5:3425-3431.  Abstract
  • Rizzieri, DA; Vredenburgh, JJ; Jones, R; Ross, M; Shpall, EJ; Hussein, A; Broadwater, G; Berry, D; Petros, WP; Gilbert, C; Affronti, ML; Coniglio, D; Rubin, P; Elkordy, M; Long, GD; Chao, NJ; Peters, WP. Prognostic and predictive factors for patients with metastatic breast cancer undergoing aggressive induction therapy followed by high-dose chemotherapy with autologous stem-cell support. Journal of Clinical Oncology. 1999;17:3064-3074.  Abstract
  • Ross, M; Schmidt, GM; Niland, JC; Amylon, MD; Dagis, AC; Long, GD; Nademanee, AP; Negrin, RS; O'Donnell, MR; Parker, PM; Smith, EP; Snyder, DS; Stein, AS; Wong, RM; Forman, SJ; Blume, KG; Chao, NJ. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prevention of acute graft-vs.-host disease: effect on chronic graft-vs.-host disease and long-term survival. Biology of Blood and Marrow Transplantation. 1999;5:285-291.  Abstract
  • Laughlin, MJ; McGaughey, DS; Crews, JR; Chao, NJ; Rizzieri, D; Ross, M; Gockerman, J; Cirrincione, C; Berry, D; Mills, L; Defusco, P; LeGrand, S; Peters, WP; Vredenburgh, JJ. Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant. Journal of Clinical Oncology. 1998;16:1008-1012.  Abstract
  • Aharoni, R; Schlegel, PG; Teitelbaum, D; Roikhel-Karpov, O; Chen, Y; Arnon, R; Sela, M; Chao, NJ. Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease. Immunology Letters. 1997;58:79-87.  Abstract
  • Chao, NJ. Graft-versus-host disease: the viewpoint from the donor T cell. Biology of Blood and Marrow Transplantation. 1997;3:1-10.  Abstract
  • Chen, Y; Schlegel, PG; Tran, N; Thompson, D; Zehnder, JL; Chao, NJ. Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. Blood. 1997;89:1452-1459.  Abstract
  • Horning, SJ; Chao, NJ; Negrin, RS; Hoppe, RT; Long, GD; Hu, WW; Wong, RM; Brown, BW; Blume, KG. High-dose therapy and autologous hematopoietic progenitor cell transplantation for recurrent or refractory Hodgkin's disease: analysis of the Stanford University results and prognostic indices. Blood. 1997;89:801-813.  Abstract
  • Kohler, S; Hendrickson, MR; Chao, NJ; Smoller, BR. Value of skin biopsies in assessing prognosis and progression of acute graft-versus-host disease. American Journal of Surgical Pathology. 1997;21:988-996.  Abstract
  • Kusnierz-Glaz, CR; Schlegel, PG; Wong, RM; Schriber, JR; Chao, NJ; Amylon, MD; Hu, WW; Negrin, RS; Lee, Y; Blume, KG; Long, GD. Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies. Journal of Clinical Oncology. 1997;15:18-25.  Abstract
  • Lee, PP; Zeng, D; McCaulay, AE; Chen, YF; Geiler, C; Umetsu, DT; Chao, NJ. T helper 2-dominant antilymphoma immune response is associated with fatal outcome. Blood. 1997;90:1611-1617.  Abstract
  • Long, GD; Amylon, MD; Stockerl-Goldstein, KE; Negrin, RS; Chao, NJ; Hu, WW; Nademanee, AP; Snyder, DS; Hoppe, RT; Vora, N; Wong, R; Niland, J; Reichardt, VL; Forman, SJ; Blume, KG. Fractionated total-body irradiation, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies. Biology of Blood and Marrow Transplantation. 1997;3:324-330.  Abstract
  • Rizzieri, DA; Chao, NJ. Treatment of non-Hodgkin's lymphoma with high-dose therapy and hematopoietic stem cell support. Current Opinion in Oncology. 1997;9:420-427.  Abstract
  • Behar, E; Chao, NJ; Hiraki, DD; Krishnaswamy, S; Brown, BW; Zehnder, JL; Grumet, FC. Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. New England Journal of Medicine. 1996;334:286-291.  Abstract
  • Chao, NJ; Parker, PM; Niland, JC; Wong, RM; Dagis, A; Long, GD; Nademanee, AP; Negrin, RS; Snyder, DS; Hu, WW; Gould, KA; Tierney, DK; Zwingenberger, K; Forman, SJ; Blume, KG. Paradoxical effect of thalidomide prophylaxis on chronic graft-vs.-host disease. Biology of Blood and Marrow Transplantation. 1996;2:86-92.  Abstract
  • Kastrissios, H; Chao, NJ; Blaschke, TF. Pharmacokinetics of high-dose oral CCNU in bone marrow transplant patients. Cancer Chemotherapy and Pharmacology. 1996;38:425-430.  Abstract
  • Long, GD; Chao, NJ; Hu, WW; Negrin, RS; Wong, RM; Blume, KG. High dose etoposide-based myeloablative therapy followed by autologous blood progenitor cell rescue in the treatment of multiple myeloma. Cancer. 1996;78:2502-2509.  Abstract
  • Parker, P; Chao, NJ; Ben-Ezra, J; Slatkin, N; Openshaw, H; Niland, JC; Linker, CA; Greffe, BS; Kashyap, A; Molina, A; Nademanee, A; O'Donnell, MR; Planas, I; Sheibani, K; Smith, EP; Snyder, DS; Spielberger, R; Stein, AS; Stepan, DE; Blume, KG; Forman, SJ. Polymyositis as a manifestation of chronic graft-versus-host disease. Medicine. 1996;75:279-285.  Abstract
  • Schlegel, PG; Aharoni, R; Chen, Y; Chen, J; Teitelbaum, D; Arnon, R; Sela, M; Chao, NJ. A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. Proceedings of the National Academy of Sciences of USA. 1996;93:5061-5066.  Abstract
  • Schlegel, PG; Chao, NJ. Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. Leukemia and Lymphoma. 1996;23:11-16.  Abstract
  • Stockerl-Goldstein, KE; Horning, SJ; Negrin, RS; Chao, NJ; Hu, WW; Long, GD; Hoppe, RT; Amylon, MD; Brown, BW; Wong, RM; Blume, KG. Influence of preparatory regimen and source of hematopoietic cells on outcome of autotransplantation for non-Hodgkin's lymphoma. Biology of Blood and Marrow Transplantation. 1996;2:76-85.  Abstract
  • Chao, NJ. Mobilization of peripheral blood progenitor cells by hematopoietic growth factors. The Canadian journal of oncology. 1995;5 Suppl 1:43-46.  Abstract
  • Chao, NJ; Blume, KG; Forman, SJ; Snyder, DS. Long-term follow-up of allogeneic bone marrow recipients for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 1995;85:3353-3354.  Abstract
  • Chao, NJ; Kastrissios, H; Long, GD; Negrin, RS; Horning, SJ; Wong, RM; Blaschke, TF; Blume, KG. A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma. Cancer. 1995;75:1354-1359.  Abstract
  • Chao, NJ; Schlegel, PG. Prevention and treatment of graft-versus-host disease. Annals of the New York Academy of Sciences. 1995;770:130-140.  Abstract
  • Fernandez, LP; Schlegel, PG; Baker, J; Chen, Y; Chao, NJ. Does thalidomide affect IL-2 response and production?. Experimental Hematology. 1995;23:978-985.  Abstract
  • Long, GD; Negrin, RS; Hoyle, CF; Kusnierz-Glaz, CR; Schriber, JR; Blume, KG; Chao, NJ. Multiple cycles of high dose chemotherapy supported by hematopoietic progenitor cells as treatment for patients with advanced malignancies. Cancer. 1995;76:860-868.  Abstract
  • Negrin, RS; Kusnierz-Glaz, CR; Still, BJ; Schriber, JR; Chao, NJ; Long, GD; Hoyle, C; Hu, WW; Horning, SJ; Brown, BW. Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma. Blood. 1995;85:3334-3341.  Abstract
  • Schlegel, PG; Vaysburd, M; Chen, Y; Butcher, EC; Chao, NJ. Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. Journal of Immunology. 1995;155:3856-3865.  Abstract
  • Zaia, JA; Schmidt, GM; Chao, NJ; Rizk, NW; Nademanee, AP; Niland, JC; Horak, DA; Lee, J; Gallez-Hawkins, G; Kusnierz-Glaz, CR. Preemptive ganciclovir administration based solely on asymptomatic pulmonary cytomegalovirus infection in allogeneic bone marrow transplant recipients: long-term follow-up. Biology of Blood and Marrow Transplantation. 1995;1:88-93.  Abstract
  • Blume, KG; Long, GD; Negrin, RS; Chao, NJ; Kusnierz-Glaz, C; Amylon, MD. Role of etoposide (VP-16) in preparatory regimens for patients with leukemia or lymphoma undergoing allogeneic bone marrow transplantation. Bone Marrow Transplantation. 1994;14 Suppl 4:S9-10.  Abstract
  • Chao, NJ; Schriber, JR; Long, GD; Negrin, RS; Catolico, M; Brown, BW; Miller, LL; Blume, KG. A randomized study of erythropoietin and granulocyte colony-stimulating factor (G-CSF) versus placebo and G-CSF for patients with Hodgkin's and non-Hodgkin's lymphoma undergoing autologous bone marrow transplantation. Blood. 1994;83:2823-2828.  Abstract
  • Schlegel, PG; Aharoni, R; Smilek, DE; Fernandez, LP; McDevitt, HO; Tran, N; Vaysburd, M; Chao, NJ. Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules. Blood. 1994;84:2802-2810.  Abstract
  • Schriber, JR; Chao, NJ; Long, GD; Negrin, RS; Tierney, DK; Kusnierz-Glaz, C; Lucas, KS; Blume, KG. Granulocyte colony-stimulating factor after allogeneic bone marrow transplantation. Blood. 1994;84:1680-1684.  Abstract
  • Snyder, DS; Negrin, RS; O'Donnell, MR; Chao, NJ; Amylon, MD; Long, GD; Nademanee, AP; Stein, AS; Parker, PM; Smith, EP. Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase. Blood. 1994;84:1672-1679.  Abstract
  • Chao, NJ; Berry, GJ; Advani, R; Horning, SJ; Weiss, LM; Blume, KG. Epstein-Barr virus-associated lymphoproliferative disorder following autologous bone marrow transplantation for non-Hodgkin's lymphoma. Transplantation. 1993;55:1425-1428.  Abstract
  • Chao, NJ; Schmidt, GM; Niland, JC; Amylon, MD; Dagis, AC; Long, GD; Nademanee, AP; Negrin, RS; O'Donnell, MR; Parker, PM. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease. New England Journal of Medicine. 1993;329:1225-1230.  Abstract
  • Chao, NJ; Schriber, JR; Grimes, K; Long, GD; Negrin, RS; Raimondi, CM; Horning, SJ; Brown, SL; Miller, L; Blume, KG. Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy. Blood. 1993;81:2031-2035.  Abstract
  • Chao, NJ; Stein, AS; Long, GD; Negrin, RS; Amylon, MD; Wong, RM; Forman, SJ; Blume, KG. Busulfan/etoposide--initial experience with a new preparatory regimen for autologous bone marrow transplantation in patients with acute nonlymphoblastic leukemia. Blood. 1993;81:319-323.  Abstract
  • Kühl, JS; Durán, GE; Chao, NJ; Sikic, BI. Effects of the methoxymorpholino derivative of doxorubicin and its bioactivated form versus doxorubicin on human leukemia and lymphoma cell lines and normal bone marrow. Cancer Chemotherapy and Pharmacology. 1993;33:10-16.  Abstract
  • Schmidt, GM; Niland, JC; Forman, SJ; Fonbuena, PP; Dagis, AC; Grant, MM; Ferrell, BR; Barr, TA; Stallbaum, BA; Chao, NJ. Extended follow-up in 212 long-term allogeneic bone marrow transplant survivors. Issues of quality of life. Transplantation. 1993;55:551-557.  Abstract
  • Schriber, JR; Negrin, RS; Chao, NJ; Long, GD; Horning, SJ; Blume, KG. The efficacy of granulocyte colony-stimulating factor following autologous bone marrow transplantation for non-Hodgkin's lymphoma with monoclonal antibody purged bone marrow. Leukemia. 1993;7:1491-1495.  Abstract
  • Snyder, DS; Chao, NJ; Amylon, MD; Taguchi, J; Long, GD; Negrin, RS; Nademanee, AP; O'Donnell, MR; Schmidt, GM; Stein, AS. Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission. Blood. 1993;82:2920-2928.  Abstract
  • Advani, R; Chao, NJ; Horning, SJ; Blume, KG; Ahn, DK; Lamborn, KR; Fleming, NC; Bonnem, EM; Greenberg, PL. Granulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjunct to autologous hemopoietic stem cell transplantation for lymphoma. Annals of Internal Medicine. 1992;116:183-189.  Abstract
  • Chao, NJ. Graft versus host disease following allogeneic bone marrow transplantation. Current Opinion in Immunology. 1992;4:571-576.  Abstract
  • Chao, NJ; Aihara, M; Kühl, JS; Sikic, BI; Blume, KG. Purging multidrug resistant cells from bone marrow. Progress in Clinical and Biological Research. 1992;377:13-23.  Abstract
  • Chao, NJ; Long, GD; Negrin, RS; Schriber, JR; Raimondi, CM; Brown, SL; Blume, KG. G-CSF and peripheral blood progenitor cells. Lancet. 1992;339:1410.  Abstract
  • Chao, NJ; Tierney, DK; Bloom, JR; Long, GD; Barr, TA; Stallbaum, BA; Wong, RM; Negrin, RS; Horning, SJ; Blume, KG. Dynamic assessment of quality of life after autologous bone marrow transplantation. Blood. 1992;80:825-830.  Abstract
  • Kühl, JS; Sikic, BI; Blume, KG; Chao, NJ. Use of etoposide in combination with cyclosporin for purging multidrug-resistant leukemic cells from bone marrow in a mouse model. Experimental Hematology. 1992;20:1048-1054.  Abstract
  • Kühl, JS; Sikic, BI; Blume, KG; Chao, NJ. Use of etoposide in combination with cyclosporine for purging multidrug resistant leukemic cells from bone marrow in a mouse model. Progress in Clinical and Biological Research. 1992;377:25-34.  Abstract
  • Marie, JP; Brophy, NA; Ehsan, MN; Aihara, Y; Mohamed, NA; Cornbleet, J; Chao, NJ; Sikic, BI. Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells. British Journal of Haematology. 1992;81:145-152.  Abstract
  • Schmidt-Wolf, IG; Aihara, M; Negrin, RS; Blume, KG; Chao, NJ. In vitro and in vivo activity of murine lymphokine-activated killer cells after cryopreservation. Transfusion. 1992;32:42-45.  Abstract
  • Aihara, M; Aihara, Y; Schmidt-Wolf, G; Schmidt-Wolf, I; Sikic, BI; Blume, KG; Chao, NJ. A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy. Blood. 1991;77:2079-2084.  Abstract
  • Chao, NJ; Duncan, SR; Long, GD; Horning, SJ; Blume, KG. Corticosteroid therapy for diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. Annals of Internal Medicine. 1991;114:145-146.  Abstract
  • Chao, NJ; Forman, SJ; Schmidt, GM; Snyder, DS; Amylon, MD; Konrad, PN; Nademanee, AP; O'Donnell, MR; Parker, PM; Stein, AS. Allogeneic bone marrow transplantation for high-risk acute lymphoblastic leukemia during first complete remission. Blood. 1991;78:1923-1927.  Abstract
  • Chao, NJ; Nademanee, AP; Long, GD; Schmidt, GM; Donlon, TA; Parker, P; Slovak, ML; Nagasawa, LS; Blume, KG; Forman, SJ. Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease. Journal of Clinical Oncology. 1991;9:1575-1579.  Abstract
  • Forman, SJ; Schmidt, GM; Nademanee, AP; Amylon, MD; Chao, NJ; Fahey, JL; Konrad, PN; Margolin, KA; Niland, JC; O'Donnell, MR. Allogeneic bone marrow transplantation as therapy for primary induction failure for patients with acute leukemia. Journal of Clinical Oncology. 1991;9:1570-1574.  Abstract
  • Horning, SJ; Chao, NJ; Negrin, RS; Hoppe, RT; Kwak, LW; Long, GD; Stallbaum, B; O'Connor, P; Blume, KG. The Stanford experience with high-dose etoposide cytoreductive regimens and autologous bone marrow transplantation in Hodgkin's disease and non-Hodgkin's lymphoma: preliminary data. Annals of Oncology. 1991;2 Suppl 1:47-50.  Abstract
  • Aihara, M; Sikic, BI; Blume, KG; Chao, NJ. Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture. Experimental Hematology. 1990;18:940-944.  Abstract
  • Blume, KG; Schmidt, GM; Chao, NJ; Forman, SJ. Bone marrow transplantation from histocompatible sibling donors for patients with acute lymphoblastic leukemia. Haematology and blood transfusion. 1990;33:636-637.  Abstract
  • Chao, NJ; Aihara, M; Blume, KG; Sikic, BI. Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow. Experimental Hematology. 1990;18:1193-1198.  Abstract
  • Chao, NJ; Amylon, MD; Long, GD; Negrin, RS; Hoppe, RT; Horning, SJ; Blume, KG. Bone marrow transplantation for hematologic malignancies: the Stanford experience. Clinical transplants. 1990;157-163.  Abstract
  • Chao, NJ; Blume, KG. Bone marrow transplantation. Part II--autologous. Western Journal of Medicine. 1990;152:46-51.  Abstract
  • Chao, NJ; Blume, KG. Bone marrow transplantation: what is the question?. Annals of Internal Medicine. 1990;113:340-341.  Abstract
  • Chao, NJ; Rosenberg, SA; Horning, SJ. CEPP(B): an effective and well-tolerated regimen in poor-risk, aggressive non-Hodgkin's lymphoma. Blood. 1990;76:1293-1298.  Abstract
  • Chao, NJ; Blume, KG. Bone marrow transplantation. Part I--Allogeneic. Western Journal of Medicine. 1989;151:638-643.  Abstract
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