Lesley Huntley Curtis


Professor in Medicine
Department / Division:
Medicine / General Internal Medicine
Address:
N Pavilion
Durham, NC 27710
Office Telephone:
(919) 668-8673
Research Interests:

Lesley H. Curtis, PhD, is professor in medicine at the Duke University School of Medicine and directs the Center for Pragmatic Health Services Research in the Duke Clinical Research Institute.

A health services researcher by training, Dr. Curtis oversees a portfolio of projects that use observational data to address questions related to clinical and comparative effectiveness, pharmacoepidemiology, health care delivery, and epidemiological trends. Dr. Curtis has considerable experience analyzing Medicare claims data, large clinical registries, and prescription drug data, and has led the linkage of large clinical registries with longitudinal Medicare claims data.  In addition, Dr. Curtis has been responsible for the linkage of those data with longitudinal cohorts in the Cardiovascular Health Study, the Framingham Heart Study, the Jackson Heart Study, and the Multi-Ethnic Study of Atherosclerosis (MESA).

Experienced in facilitating large-scale multi-institutional research through the use of distributed health data networks, Curtis co-leads the Data Core for the FDA’s Mini-Sentinel Initiative, co-leads the Electronic Health Record Core for the NIH’s Health Care Systems Collaboratory, and co-leads the Data Standards, Security, Networking, and Infrastructure Task Force for the Patient-Centered Outcomes Research Initiative’s National Clinical Research Network.

Representative Publications:
  • Curtis, LH; Hammill, BG; Qualls, LG; DiMartino, LD; Wang, F; Schulman, KA; Cousins, SW. Treatment patterns for neovascular age-related macular degeneration: analysis of 284 380 medicare beneficiaries. American Journal of Ophthalmology. 2012;153:1116-24.e1.  Abstract
  • Curtis, LH; Weiner, MG; Boudreau, DM; Cooper, WO; Daniel, GW; Nair, VP; Raebel, MA; Beaulieu, NU; Rosofsky, R; Woodworth, TS; Brown, JS. Design considerations, architecture, and use of the Mini-Sentinel distributed data system. Pharmacoepidemiology and Drug Safety. 2012;21 Suppl 1:23-31.  Abstract
  • Douglas, PS; Curtis, LH. Is biology destiny or can we optimize care for all patients?. Annals of Internal Medicine. 2012;156:241-242.  Abstract
  • Greiner, MA; Hammill, BG; Fonarow, GC; Whellan, DJ; Eapen, ZJ; Hernandez, AF; Curtis, LH. Predicting costs among medicare beneficiaries with heart failure. American Journal of Cardiology. 2012;109:705-711.  Abstract
  • Piccini, JP; Hammill, BG; Sinner, MF; Jensen, PN; Hernandez, AF; Heckbert, SR; Benjamin, EJ; Curtis, LH. Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007. Circulation: Cardiovascular Quality and Outcomes. 2012;5:85-93.  Abstract
  • Piccini, JP; Mi, X; DeWald, TA; Go, AS; Hernandez, AF; Curtis, LH. Pharmacotherapy in Medicare beneficiaries with atrial fibrillation. Heart Rhythm. 2012;9:1403-1408.  Abstract
  • Unroe, KT; Greiner, MA; Colón-Emeric, C; Peterson, ED; Curtis, LH. Associations between published quality ratings of skilled nursing facilities and outcomes of medicare beneficiaries with heart failure. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 2012;13:188.e1-188.e6.  Abstract
  • Curtis, LH; Greiner, MA; Shea, AM; Whellan, DJ; Hammill, BG; Schulman, KA; Douglas, PS. Assessment of left ventricular function in older Medicare beneficiaries with newly diagnosed heart failure. Circulation: Cardiovascular Quality and Outcomes. 2011;4:85-91.  Abstract
  • Hernandez, AF; Curtis, LH. Minding the gap between efforts to reduce readmissions and disparities. JAMA: Journal of the American Medical Association. 2011;305:715-716.  Abstract
  • Unroe, KT; Greiner, MA; Hernandez, AF; Whellan, DJ; Kaul, P; Schulman, KA; Peterson, ED; Curtis, LH. Resource use in the last 6 months of life among medicare beneficiaries with heart failure, 2000-2007. Archives of Internal Medicine. 2011;171:196-203.  Abstract
  • Curtis, LH; Greiner, MA; Patel, MR; Duncan, PW; Schulman, KA; Matchar, DB. Geographic variation and trends in carotid imaging among medicare beneficiaries, 2001 to 2006. Circulation: Cardiovascular Quality and Outcomes. 2010;3:599-606.  Abstract
  • Curtis, LH; Hammill, BG; Schulman, KA; Cousins, SW. Risks of mortality, myocardial infarction, bleeding, and stroke associated with therapies for age-related macular degeneration. Archives of Ophthalmology. 2010;128:1273-1279.  Abstract
  • DiMartino, LD; Shea, AM; Hernandez, AF; Curtis, LH. Use of guideline-recommended therapies for heart failure in the Medicare population. Clinical Cardiology (Hoboken): an indexed and peer-reviewed journal for advances in the treatment of cardiovascular disease. 2010;33:400-405.  Abstract
  • Fekrat, S; Shea, AM; Hammill, BG; Nguyen, H; Kowalski, JW; Schulman, KA; Curtis, LH. Resource use and costs of branch and central retinal vein occlusion in the elderly. Current Medical Research and Opinion. 2010;26:223-230.  Abstract
  • Hernandez, AF; Fonarow, GC; Hammill, BG; Al-Khatib, SM; Yancy, CW; O'Connor, CM; Schulman, KA; Peterson, ED; Curtis, LH. Clinical effectiveness of implantable cardioverter-defibrillators among medicare beneficiaries with heart failure. Circulation. Heart failure. 2010;3:7-13.  Abstract
  • Hernandez, AF; Greiner, MA; Fonarow, GC; Hammill, BG; Heidenreich, PA; Yancy, CW; Peterson, ED; Curtis, LH. Relationship between early physician follow-up and 30-day readmission among Medicare beneficiaries hospitalized for heart failure. JAMA: Journal of the American Medical Association. 2010;303:1716-1722.  Abstract
  • Kociol, RD; Hammill, BG; Fonarow, GC; Klaskala, W; Mills, RM; Hernandez, AF; Curtis, LH. Generalizability and longitudinal outcomes of a national heart failure clinical registry: Comparison of Acute Decompensated Heart Failure National Registry (ADHERE) and non-ADHERE Medicare beneficiaries. American Heart Journal. 2010;160:885-892.  Abstract
  • Patel, MR; Greiner, MA; DiMartino, LD; Schulman, KA; Duncan, PW; Matchar, DB; Curtis, LH. Geographic variation in carotid revascularization among Medicare beneficiaries, 2003-2006. Archives of Internal Medicine. 2010;170:1218-1225.  Abstract
  • Patel, UD; Greiner, MA; Fonarow, GC; Phatak, H; Hernandez, AF; Curtis, LH. Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failure. American Heart Journal. 2010;160:132-138.e1.  Abstract
  • Patterson, ME; Hernandez, AF; Hammill, BG; Fonarow, GC; Peterson, ED; Schulman, KA; Curtis, LH. Process of care performance measures and long-term outcomes in patients hospitalized with heart failure. Medical Care. 2010;48:210-216.  Abstract
  • Petersen, JL; Barron, JJ; Hammill, BG; Cziraky, MJ; Anstrom, KJ; Wahl, PM; Eisenstein, EL; Krucoff, MW; Califf, RM; Schulman, KA; Curtis, LH. Clopidogrel use and clinical events after drug-eluting stent implantation: findings from the HealthCore Integrated Research Database. American Heart Journal. 2010;159:462-470.e1.  Abstract
  • Whellan, DJ; Greiner, MA; Schulman, KA; Curtis, LH. Costs of inpatient care among Medicare beneficiaries with heart failure, 2001 to 2004. Circulation: Cardiovascular Quality and Outcomes. 2010;3:33-40.  Abstract
  • Curtis, LH; Greiner, MA; Hammill, BG; DiMartino, LD; Shea, AM; Hernandez, AF; Fonarow, GC. Representativeness of a national heart failure quality-of-care registry: comparison of OPTIMIZE-HF and non-OPTIMIZE-HF Medicare patients. Circulation: Cardiovascular Quality and Outcomes. 2009;2:377-384.  Abstract
  • Hammill, BG; Hernandez, AF; Peterson, ED; Fonarow, GC; Schulman, KA; Curtis, LH. Linking inpatient clinical registry data to Medicare claims data using indirect identifiers. American Heart Journal. 2009;157:995-1000.  Abstract
  • Al-Khatib, SM; Greiner, MA; Peterson, ED; Hernandez, AF; Schulman, KA; Curtis, LH. Patient and implanting physician factors associated with mortality and complications after implantable cardioverter-defibrillator implantation, 2002-2005. Circulation: Arrhythmia and Electrophysiology. 2008;1:240-249.  Abstract
  • Curtis, LH; Greiner, MA; Hammill, BG; Kramer, JM; Whellan, DJ; Schulman, KA; Hernandez, AF. Early and long-term outcomes of heart failure in elderly persons, 2001-2005. Archives of Internal Medicine. 2008;168:2481-2488.  Abstract
  • Curtis, LH; Hammill, BG; Bethel, MA; Anstrom, KJ; Liao, L; Gottdiener, JS; Schulman, KA. Pancreatic beta-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health Study. Current Medical Research and Opinion. 2008;24:41-50.  Abstract
  • Curtis, LH; Whellan, DJ; Hammill, BG; Hernandez, AF; Anstrom, KJ; Shea, AM; Schulman, KA. Incidence and prevalence of heart failure in elderly persons, 1994-2003. Archives of Internal Medicine. 2008;168:418-424.  Abstract
  • Hernandez, AF; Shea, AM; Milano, CA; Rogers, JG; Hammill, BG; O'Connor, CM; Schulman, KA; Peterson, ED; Curtis, LH. Long-term outcomes and costs of ventricular assist devices among Medicare beneficiaries. JAMA: Journal of the American Medical Association. 2008;300:2398-2406.  Abstract
  • Shea, AM; Curtis, LH; Hammill, BG; DiMartino, LD; Abernethy, AP; Schulman, KA. Association between the Medicare Modernization Act of 2003 and patient wait times and travel distance for chemotherapy. JAMA: Journal of the American Medical Association. 2008;300:189-196.  Abstract
  • Curtis, LH; Al-Khatib, SM; Shea, AM; Hammill, BG; Hernandez, AF; Schulman, KA. Sex differences in the use of implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac death. JAMA: Journal of the American Medical Association. 2007;298:1517-1524.  Abstract
  • Curtis, LH; Hammill, BG; Bethel, MA; Anstrom, KJ; Gottdiener, JS; Schulman, KA. Costs of the metabolic syndrome in elderly individuals: findings from the Cardiovascular Health Study. Diabetes Care. 2007;30:2553-2558.  Abstract
  • Curtis, LH; Hammill, BG; Eisenstein, EL; Kramer, JM; Anstrom, KJ. Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases. Medical Care. 2007;45:S103-S107.  Abstract
  • Hernandez, AF; Fonarow, GC; Liang, L; Al-Khatib, SM; Curtis, LH; LaBresh, KA; Yancy, CW; Albert, NM; Peterson, ED. Sex and racial differences in the use of implantable cardioverter-defibrillators among patients hospitalized with heart failure. JAMA: Journal of the American Medical Association. 2007;298:1525-1532.  Abstract
  • Curtis, LH; Stoddard, J; Radeva, JI; Hutchison, S; Dans, PE; Wright, A; Woosley, RL; Schulman, KA. Geographic variation in the prescription of schedule II opioid analgesics among outpatients in the United States. Health Services Research. 2006;41:837-855.  Abstract
  • Curtis, LH; Masselink, LE; Østbye, T; Hutchison, S; Dans, PE; Wright, A; Krishnan, RR; Schulman, KA. Prevalence of atypical antipsychotic drug use among commercially insured youths in the United States. Archives of Pediatrics and Adolescent Medicine. 2005;159:362-366.  Abstract
  • Curtis, LH; Law, AW; Anstrom, KJ; Schulman, KA. The insurance effect on prescription drug expenditures among the elderly: findings from the 1997 Medical Expenditure Panel Survey. Medical Care. 2004;42:439-446.  Abstract
  • Curtis, LH; Østbye, T; Sendersky, V; Hutchison, S; Dans, PE; Wright, A; Woosley, RL; Schulman, KA. Inappropriate prescribing for elderly Americans in a large outpatient population. Archives of Internal Medicine. 2004;164:1621-1625.  Abstract
  • Curtis, LH; Østbye, T; Sendersky, V; Hutchison, S; Allen LaPointe, NM; Al-Khatib, SM; Usdin Yasuda, S; Dans, PE; Wright, A; Califf, RM; Woosley, RL; Schulman, KA. Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients. American Journal of Medicine. 2003;114:135-141.  Abstract
  • Curtis, LH; Phelps, CE; McDermott, MP; Rubin, HR. The value of patient-reported health status in predicting short-term outcomes after coronary artery bypass graft surgery. Medical Care. 2002;40:1090-1100.  Abstract
end fo content area