Uptal D. Patel, MD

Associate Professor of Medicine
Associate Professor in Pediatrics
Department / Division:
Medicine / Medicine-Nephrology
DUMC 3646
Durham, NC 27710
Appointment Telephone:
Office Telephone:
  • MD, University of California–San Francisco, School of Medicine, 1997
  • Medicine and Pediatrics, University of Michigan, 1997-2001
  • Pediatric Nephrology, University of Michigan, 2001-2005
  • Adult Nephrology, University of Michigan, 2002-2005
  • Robert Wood Johnson Clinical Scholars Program, 2003-2005
Clinical Interests:
Adult and pediatric nephrology, cardiovascular risk reduction and other management strategies for patients with chronic kidney disease, transitional care for children and adolescents with kidney disease
Research Interests:
Uptal Patel, MD, is an Associate Professor of Medicine and Pediatrics, and Director of Nephrology Research at the Duke Clinical Research Institute. As an adult and pediatric nephrologist with training in health services and epidemiology, his work seeks to develop health care systems-level strategies to optimize population management for chronic diseases, with a focus on acute and chronic kidney disease through four inter-related areas that are essential to improving kidney health: (1) reducing the progression of chronic kidney disease by improving its detection and management, particularly by leveraging technology to facilitate patient engagement and self-management; (2) elucidating the inter-relationships between kidney disease and cardiovascular disease, which together amplify the risk of death; (3) improving the evidence in nephrology through comparative effectiveness research, including clinical trials, observational studies, and meta-analyses; and (4) promoting more optimal clinical health policy for all patients with kidney disease. These inter-disciplinary projects have been funded by a variety of public and private sources including the NIH, AHRQ, VA, FDA, RWJ Foundation, RPA, and ASN.
Representative Publications:
  • Hall, RK; Wang, V; Jackson, GL; Hammill, BG; Maciejewski, ML; Yano, EM; Svetkey, LP; Patel, UD. Implementation of automated reporting of estimated glomerular filtration rate among Veterans Affairs laboratories: a retrospective study. BMC Medical Informatics and Decision Making. 2012;12:69.  Abstract
  • Patel, UD; Garg, AX; Krumholz, HM; Shlipak, MG; Coca, SG; Sint, K; Thiessen-Philbrook, H; Koyner, JL; Swaminathan, M; Passik, CS; Parikh, CR; Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consortium. Preoperative serum brain natriuretic peptide and risk of acute kidney injury after cardiac surgery. Circulation. 2012;125:1347-1355.  Abstract
  • Schell, JO; Patel, UD; Steinhauser, KE; Ammarell, N; Tulsky, JA. Discussions of the kidney disease trajectory by elderly patients and nephrologists: a qualitative study. American Journal of Kidney Diseases. 2012;59:495-503.  Abstract
  • Kagoma, YK; Weir, MA; Iansavichus, AV; Hemmelgarn, BR; Akbari, A; Patel, UD; Garg, AX; Jain, AK. Impact of estimated GFR reporting on patients, clinicians, and health-care systems: a systematic review. American Journal of Kidney Diseases. 2011;57:592-601.  Abstract
  • Orlando, LA; Belasco, EJ; Patel, UD; Matchar, DB. The chronic kidney disease model: a general purpose model of disease progression and treatment. BMC Medical Informatics and Decision Making. 2011;11:41.  Abstract
  • Parikh, CR; Coca, SG; Thiessen-Philbrook, H; Shlipak, MG; Koyner, JL; Wang, Z; Edelstein, CL; Devarajan, P; Patel, UD; Zappitelli, M; Krawczeski, CD; Passik, CS; Swaminathan, M; Garg, AX; TRIBE-AKI Consortium. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. Journal of the American Society of Nephrology : JASN. 2011;22:1748-1757.  Abstract
  • Parikh, DS; Swaminathan, M; Archer, LE; Inrig, JK; Szczech, LA; Shaw, AD; Patel, UD. Perioperative outcomes among patients with end-stage renal disease following coronary artery bypass surgery in the USA. Nephrology Dialysis Transplantation. 2010;25:2275-2283.  Abstract
  • Patel, UD. Fetal origins of renal disparities. Seminars in Nephrology. 2010;30:42-50.  Abstract
  • Patel, UD; Greiner, MA; Fonarow, GC; Phatak, H; Hernandez, AF; Curtis, LH. Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failure. American Heart Journal. 2010;160:132-138.e1.  Abstract
  • Patel, UD; Ou, FS; Ohman, EM; Gibler, WB; Pollack, CV; Peterson, ED; Roe, MT. Hospital performance and differences by kidney function in the use of recommended therapies after non-ST-elevation acute coronary syndromes. American Journal of Kidney Diseases. 2009;53:426-437.  Abstract
  • Patwardhan, MB; Kawamoto, K; Lobach, D; Patel, UD; Matchar, DB. Recommendations for a clinical decision support for the management of individuals with chronic kidney disease. Clinical journal of the American Society of Nephrology : CJASN. 2009;4:273-283.  Abstract
  • Ellis, MJ; Parikh, CR; Inrig, JK; Kanbay, M; Patel, UD. Chronic kidney disease after hematopoietic cell transplantation: a systematic review. American Journal of Transplantation. 2008;8:2378-2390.  Abstract
  • Hudson, C; Hudson, J; Swaminathan, M; Shaw, A; Stafford-Smith, M; Patel, UD. Emerging concepts in acute kidney injury following cardiac surgery. Seminars in Cardiothoracic and Vascular Anesthesia. 2008;12:320-330.  Abstract
  • Matchar, DB; McCrory, DC; Orlando, LA; Patel, MR; Patel, UD; Patwardhan, MB; Powers, B; Samsa, GP; Gray, RN. Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Annals of internal medicine. 2008;148:16-29.  Abstract
  • Patel, UD; Hernandez, AF; Liang, L; Peterson, ED; LaBresh, KA; Yancy, CW; Albert, NM; Ellrodt, G; Fonarow, GC. Quality of care and outcomes among patients with heart failure and chronic kidney disease: A Get With the Guidelines -- Heart Failure Program study. American Heart Journal. 2008;156:674-681.  Abstract
  • Patel, UD; Davis, MM. Falling into the doughnut hole: drug spending among beneficiaries with end-stage renal disease under Medicare Part D plans. Journal of the American Society of Nephrology : JASN. 2006;17:2546-2553.  Abstract
  • Patel, UD; Davis, MM. Physicians' attitudes and practices regarding adherence to medical regimens by patients with chronic illness. Clinical Pediatrics. 2006;45:439-445.  Abstract
  • Patel, UD; Young, EW; Ojo, AO; Hayward, RA. CKD progression and mortality among older patients with diabetes. American Journal of Kidney Diseases. 2005;46:406-414.  Abstract
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