Megan E.B. Clowse, MD, MPH

Associate Professor of Medicine
Department / Division:
Medicine / Medicine-Rheumatology and Immunology
DUMC 3535
Durham, NC 27710
Appointment Telephone:
Office Telephone:
  • MD, Vanderbilt University School of Medicine (Tennessee), 1999
  • Internal Medicine, Johns Hopkins Hospital (Maryland), 1999-2002
  • Rheumatology, Johns Hopkins Hospital (Maryland), 2002-2005
Other Training:
  • MPH, University of California–Los Angeles, 1993-1994
Clinical Interests:
Pregnancy in women with rheumatic disease, lupus, antiphospholipid syndrome, inflammatory arthritis, vasculitis
Research Interests:
I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  
Representative Publications:
  • Clowse, ME; Magder, LS; Petri, M. The clinical utility of measuring complement and anti-dsDNA antibodies during pregnancy in patients with systemic lupus erythematosus. The Journal of rheumatology. 2011;38:1012-1016.  Abstract
  • Crochet, JR; Yeh, JS; Clowse, ME; Copland, SD. Late ovarian hyperstimulation syndrome after controlled ovarian stimulation in a woman with systemic lupus erythematosus and lupus nephritis. Fertility and Sterility. 2011;95:1786.e13-1786.e16.  Abstract
  • Clowse, ME. Managing contraception and pregnancy in the rheumatologic diseases. Best Practice and Research: Clinical Rheumatology. 2010;24:373-385.  Abstract
  • Clowse, ME. The use of anti-TNF¿ medications for rheumatologic disease in pregnancy. International Journal of Women's Health. 2010;2:199-209.  Abstract
  • Mitchell, K; Kaul, M; Clowse, ME. The management of rheumatic diseases in pregnancy. Scandinavian Journal of Rheumatology (Informa). 2010;39:99-108.  Abstract
  • Clowse, ME; Jamison, M; Myers, E; James, AH. A national study of the complications of lupus in pregnancy. American Journal of Obstetrics & Gynecology. 2008;199:127.e1-127.e6.  Abstract
  • Clowse, ME. Lupus activity in pregnancy. Rheumatic Disease Clinics of North America. 2007;33:237-v.  Abstract
  • Clowse, ME; Magder, L; Witter, F; Petri, M. Hydroxychloroquine in lupus pregnancy. Arthritis and Rheumatism. 2006;54:3640-3647.  Abstract
  • Clowse, ME; Magder, LS; Witter, F; Petri, M. Early risk factors for pregnancy loss in lupus. Obstetrics & Gynecology (Elsevier). 2006;107:293-299.  Abstract
  • Clowse, ME; Magder, L; Petri, M. Cyclophosphamide for lupus during pregnancy. Lupus. 2005;14:593-597.  Abstract
  • Clowse, ME; Magder, LS; Witter, F; Petri, M. The impact of increased lupus activity on obstetric outcomes. Arthritis and Rheumatism. 2005;52:514-521.  Abstract
  • Clowse, ME; Wigley, FM. Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis. The Journal of rheumatology. 2003;30:1341-1343.  Abstract
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