Clinical Trials and Implementation Research

Jennifer Green, MD, Associate Professor of Medicine. Dr. Green’s research has focused upon the effects of various interventions to modify glycemic control, dyslipidemia, and hypertension upon cardiovascular and other diabetes-related complications.  She has served as an investigator in clinical trials of glycemic management in type 2 diabetes including ACCORD, BARI 2D, and the recently-initiated GRADE study.  Her work with the DCRI includes protocol development as well as clinical and operational leadership for the institution’s management of the international cardiovascular outcomes trial TECOS, which assessed the impact of sitagliptin therapy upon cardiovascular event rates.  She is currently the DCRI clinical lead for Harmony Outcomes, an international trial designed to assess the cardiovascular impact of albiglutide therapy in a high cardiovascular risk population, and has served as chair of clinical events adjudication committees for several large cardiovascular outcomes trials of antihyperglycemic medications.

Susan Spratt, MD, Assistant Professor of Medicine and Community and Family Medicine. Dr. Spratt’s research focuses on management of diabetes in underserved populations. This work includes developing phenotypes for diabetes identification in secondary data analysis; identifying patient perceptions and ethical issues involved in secondary data analysis; using geospatial analysis, risk assessment and community engagement to reduce death and disability in patients with diabetes; and community outreach through the Durham Diabetes Coalition and Southeastern Diabetes Initiative.

Matt Crowley, MD, Assistant Professor of Medicine. Dr. Crowley’s research centers on evaluating health services interventions designed to improve outcomes in diabetes and hypertension. His primary focus is the development of scalable, patient-centered diabetes management interventions for individuals with persistently poor glycemic control despite routine care; he has a particular interest in moving disease management beyond the standard clinic setting using group visits, telemedicine, and eHealth strategies that can be implemented in the ‘real world.’ Dr. Crowley is principal investigator on two trials evaluating telemedicine/eHealth interventions for patients with persistent poorly-controlled diabetes, and he is a co-investigator on multiple VA- and NIH-funded diabetes and hypertension trials. He has a secondary interest in systematic review and future research prioritization, having served as an investigator on several VA-, AHRQ-, and PCORI-funded projects. In 2014, he received a Career Development Award from VA Health Services Research and Development to support his research efforts. Read more.

Bryan Batch, MD, Assistant Professor of Medicine. Dr. Batch works on the design, adaptation and implementation of behavioral lifestyle interventions targeted to overweight, obese and diabetic people. Her focus is on variation in the demographics and responses among different racial/ethnic patient groups and how to explain and correct these disparities.

Richard Lee, MD, Assistant Professor of Medicine. Dr Lee is an expert in metabolic bone disease and does studies at the Durham VAMC focused on risks for osteoporosis and approaches for prevention of fractures. He has developed management strategies to enhance screening and treatment of osteoporosis in male veterans.