Liddle Laboratory

Rodger Liddle, MD, Primary Investigator

Rodger Liddle, MD
Professor of Medicine

Member
Duke Institute for Brain Sciences
Duke Cancer Institute

Location:
Room 1033A, Genome Science Research Building-1
905 S. LaSalle Street
Duke University Medical Center
Durham, NC 27710

Campus Mail:
Box 103859

Contact:
919-681-6380
rodger.liddle@duke.edu

Education

B.S., University of Utah, 1972
M.D., Vanderbilt University, 1978
Internship (Medicine), University of California, San Francisco, 1979
Residency (Medicine), University of California, San Francisco, 1981
Fellowship (Gastroenterology), University of California, San Francisco, 1984

Research Interests

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’. Our laboratory has conducted pioneering studies to characterize the structure and function of neuropods and have proposed novel and creative studies that will characterize a new concept for how enteroendocrine cells communicate with the nervous system. This newly discovered neural circuit is a point of communication between food and bacteria in the gut and the nervous system and has been referred to as the first step in the gut connectome. Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreatic activation of digestive enzymes.  Our laboratory is studying the mechanisms involved in the development of pancreatitis.  These studies have defined the importance of endogenous pancreatic secretory trypsin inhibitor PSTI (also known as serine protease Kazal type – SPINK) in the generation and prevention of pancreatitis.  We have also described the importance of neurogenic inflammation in the initiation of pancreatitis.  We have demonstrated that primary sensory neurons play a key role in acute pancreatitis and that the cation channel TRPV1 is a key mediator of pancreatic inflammation resulting from most causes clinical pancreatitis including alcohol and gallstone pancreatitis.  We have identified the endogenous activator of TRPV1 and have evidence these mechanisms are relevant to human pancreatitis.  Recently, we identified a mechanically activated ion channel Piezo1 in the pancreas that mediates pressure-induced pancreatic injury.  We believe this is the mechanism for trauma, surgery, ERCP, and gallstone induced pancreatitis.  Our goal is to identify novel targets for treating acute pancreatitis.

Grants

“Mechanisms of mechanically-induced acute pancreatitis” - NIH
“The Role of Gut Endocrine Cells in Parkinson's disease" - NIH
“Gut Neuroendocrine Cell Signaling” - VA

Lab Members

Rodger Liddle, MD 
Primary Investigator

Rashmi Chandra, PhD 
Senior Research Scientist

Joelle Romac, PhD
Senior Research Scientist

Stephanie King, MS
Research Scientist

Steven R. Vigna, PhD
Associate Professor of Cell Biology and Medicine

Lihua Ye
Postdoctoral Fellow

Courtney Richman
Student

Former Lab Members

Diego Bohorquez, PhD
Christi Ballard
Bryant Beebe
Yu Wang, PhD
Alan Erdmann, MD
Fariha Haque
​Mash Haque
Anthony Therattil
Alex Kreger
Supriya Davis
Brian Fee, PhD
Barry Gooch, PhD
Lee Ann Samsa
M. F. Majeed
John Humphrey, MD
Marc Noble, MD
Michael Peyton, PhD
Jaimie Nathan, MD
Akash Patel, MD
Lee Ann Scott
Jasmine Hayes
Laine Hurst
Ala Sharara, MD
Nicholas Snow, MD
Yoshifumi Higashimoto, MD, PhD
Ernest Bouras, MD
Paul Yudelman, MD
Shuji Kanayama, MD, PhD
Tom Geracioti, MD
Robert Rushakoff, MD
Randy Taplitz, MD
Jacqueline Carter
Carol Conrad
Rafiq Shahid, MD
Ahmad Farooq, MD