Brander Lab

Danielle Marie Brander, MD, Primary Investigator

Education

Resident, Internal Medicine, Duke University School of Medicine, 2007 - 2010
M.D., Duke University School of Medicine, 2007

Research in the Brander Lab focuses on Clinical Research Projects for CLL and Indolent Lymphoma.

Lab Members

Danielle Brander, MD
Assistant Professor of Medicine
Member of the Duke Cancer Institute

Tiffany Stewart
Research Analyst I

Current Studies

Clinical Research Projects: CLL and Indolent Lymphoma
Site PI for CLL & Indolent Lymphoma Investigator Initiated and sponsored trials (7 trials with active patients)
Participate in multi-center retrospective analysis of outcomes for CLL pts treated with the novel kinase and BCL2 inhibitors (i.e. ibrutinib, idelalisib, venetoclax)
Translational Research Projects: Understanding Resistance & Toxicity to Targeted Therapeutics in CLL
Surface immunoglobulin (sIg) isotype and expression heterogeneity as a mechanism of disease variability and resistance in CLL
Changes in CLL immunophenotype and p-proteins as mechanism of resistance for pts treated in the PhI trial of lenalidomide plus plerixafor in rel/ref CLL
Increased SETα/β-ratio by qPCR as an adverse prognostic marker in CLL pts
Identifying mechanisms of bleeding toxicities in CLL patients on therapeutic BTK inhibitors