Chenyu Lin, MD

Start Year
2020

Education and Training

College/University
Yale College

Medical School
University of Chicago Pritzker School of Medicine

Residency
Northwestern Memorial Hospital

Career and Research Goals

My primary research interest involves investigating novel allogeneic cellular therapy and stem cell transplant strategies in the treatment of advanced hematologic malignancies. With Dr. Matthew McKinney and Dr. Richard Lopez, we are currently designing an early phase clinical trial studying an ex vivo phosphoantigen-expanded gamma-delta T cell immunotherapy targeting aggressive B cell lymphomas and acute leukemias. On the transplant side, under the mentorship of Dr. Mitchell Horwitz and Dr. Anthony Sung, I have been working on secondary analyses assessing health-related quality of life and the long-term durability of omidubicel, an ex vivo expanded stem cell product derived from umbilical cord blood. My research in allogeneic hematopoietic stem cell transplantation has also expanded to explore the use of Syk inhibition in the prevention and treatment of chronic graft versus host disease, under the guidance of Dr. Stefanie Sarantopoulos and Dr. Mitchell Horwitz. My other clinical/research interests include tele-oncology and ctDNA biomarkers..

What are the strengths of the Duke program?

I believe the real strength of the Duke hematology/oncology fellowship program comes from the people who work here. The faculty are wonderful mentors and are incredibly supportive of both your personal and academic goals. The work environment here is also quite collegial and prioritizes your learning. The attendings, pharmacists, and APPs/PAs are all very invested in your education and will go out of their way on a busy clinical day to help you learn the skills you need to become a successful hematologist/oncologist. Fellowship can be very challenging, especially in the first year, but knowing you are supported as a new fellow makes all the difference in your education and quality of life.

Publications

Zhou, Katherine, Chenyu Lin, Michelle Green, Bennett Caughey, Michael Datto, John Strickler, and Matthew McKinney. “Frequency of Practice-Changing Findings Identified by Comprehensive Genomic Profiling in Non-Myeloid Hematologic Malignancies.” In American Society of Clinical Oncology, 2022.

Scholars@Duke

Lin, Chenyu, Laura Morrison, Edwin Alyea, Taewoong Choi, Cristina Gasparetto, Gwynn Long, Richard Lopez, et al. “Allogeneic Stem Cell Transplantation with Omidubicel: Long-Term Follow-Up from a Single Center.” American Society of Hematology, 2021.

Scholars@Duke

Islam, Prioty, David Rizzieri, Chenyu Lin, Carlos de Castro, Louis Diehl, Zhiguo Li, Joseph Moore, Tod Morris, and Anne Beaven. “Phase II Study of Single-Agent and Combination Everolimus and Panobinostat in Relapsed or Refractory Diffuse Large B-Cell Lymphoma.” Cancer Invest 39, no. 10 (November 2021): 871–79. https://doi.org/10.1080/07357907.2021.1983584.

PMID
34643126
Full Text

Shah, Ami N., Kristen J. Carroll, Lorenzo Gerratana, Chenyu Lin, Andrew A. Davis, Qiang Zhang, Saya Jacob, et al. “Circulating tumor cells, circulating tumor DNA, and disease characteristics in young women with metastatic breast cancer.” Breast Cancer Research and Treatment 187, no. 2 (June 2, 2021): 397–405. https://doi.org/10.1007/s10549-021-06236-1.

PMID
34076801
Full Text

Gerratana, Lorenzo, Andrew A. Davis, Maurizio Polano, Qiang Zhang, Ami N. Shah, Chenyu Lin, Debora Basile, et al. “Understanding the organ tropism of metastatic breast cancer through the combination of liquid biopsy tools.” European Journal of Cancer 143 (January 2021): 147–57. https://doi.org/10.1016/j.ejca.2020.11.005.

Full Text

Lin, Chenyu, Karlyn A. Martin, Mei Wang, Brady L. Stein, and Kush R. Desai. “Long-term antithrombotic therapy after venous stent placement.” Phlebology: The Journal of Venous Disease 35, no. 6 (July 2020): 402–8. https://doi.org/10.1177/0268355519893819.

Full Text

Shah, Ami, Brian Finkelman, Lorenzo Gerratana, Andrew Davis, Neelima Katam, Chenyu Lin, Kristen Carroll, et al. “ERBB2 amplifications and mutations in 109 advanced breast cancer patients by next-generation sequencing.” In Journal of Clinical Oncology, Vol. 38. American Society of Clinical Oncology, 2020.

Scholars@Duke

Gerratana, Lorenzo, Andrew A. Davis, Ami N. Shah, Chenyu Lin, Carla Corvaja, and Massimo Cristofanilli. “Emerging Role of Genomics and Cell-Free DNA in Breast Cancer.” Current Treatment Options in Oncology 20, no. 8 (August 2019). https://doi.org/10.1007/s11864-019-0667-9.

Full Text

Lin, Chenyu, Karlyn Martin, Mei Wang, Brady Stein, and Kush Desai. “Long-Term Antithrombotic Therapy after Venous Stent Placement.” In Blood, Vol. 132. American Society of Hematology, 2018.

Scholars@Duke

Meyer, S., R. Ramot, K. Kishore Inampudi, B. Luo, C. Lin, S. Amere, and C. J. Wilson. “Engineering alternate cooperative-communications in the lactose repressor protein scaffold.” Protein Engineering Design and Selection 26, no. 6 (June 1, 2013): 433–43. https://doi.org/10.1093/protein/gzt013.

Full Text