Jacob Kaufman, MD, PhD

Start Year
2017

Education and Training

College/University
Vanderbilt University

Medical School
MD, PhD - Vanderbilt University

Residency
Duke University

Publications

Kaufman, Jacob, and Thomas E. Stinchcombe. “Treatment of KRAS-Mutant Non-Small Cell Lung Cancer: The End of the Beginning for Targeted Therapies..” Jama 317, no. 18 (May 2017): 1835–37. https://doi.org/10.1001/jama.2017.3436.

PMID
28492885
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Kaufman, Jacob M., Tadaaki Yamada, Kyungho Park, Cynthia D. Timmers, Joseph M. Amann, and David P. Carbone. “A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma..” Cancer Research 77, no. 1 (January 2017): 153–63. https://doi.org/10.1158/0008-5472.can-16-1639.

PMID
27821489
Full Text

Whang, Y. M., S. I. Park, I. A. Trenary, R. A. Egnatchik, J. P. Fessel, J. M. Kaufman, D. P. Carbone, and J. D. Young. “LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells..” Oncogene 35, no. 7 (February 2016): 856–66. https://doi.org/10.1038/onc.2015.140.

PMID
26119936
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Kaufman, Jacob M., Joseph M. Amann, Kyungho Park, Rajeswara Rao Arasada, Haotian Li, Yu Shyr, and David P. Carbone. “LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT..” Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 9, no. 6 (June 2014): 794–804. https://doi.org/10.1097/JTO.0000000000000173.

PMID
24828662
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Kikuchi, Takefumi, Mohamed Hassanein, Joseph M. Amann, Qinfeng Liu, Robbert J. C. Slebos, SM Jamshedur Rahman, Jacob M. Kaufman, et al. “In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers..” Molecular & Cellular Proteomics : Mcp 11, no. 10 (October 2012): 916–32. https://doi.org/10.1074/mcp.M111.015370.

PMID
22761400
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Cancer Genome Atlas Research Network, Mohamad A. “Comprehensive genomic characterization of squamous cell lung cancers..” Nature 489, no. 7417 (September 9, 2012): 519–25. https://doi.org/10.1038/nature11404.

PMID
22960745
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Samanta, Debangshu, Jacob Kaufman, David P. Carbone, and Pran K. Datta. “Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer..” Neoplasia (New York, N.Y.) 14, no. 7 (July 2012): 644–55. https://doi.org/10.1593/neo.12548.

PMID
22904681
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Piecek, W., J. M. Kaufman, and P. Kaszynski. “A comparison of mesogenic properties for one- and two-ring dipentyl derivatives of p-carboranes, bicyclo[2.2.2]octane, and benzene.” Liquid Crystals 30, no. 1 (January 1, 2003): 39–48. https://doi.org/10.1080/0267829021000039669.

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