Stephen Greene, MD

Start Year

Education and Training

Northwestern University

Medical School
Northwestern University Feinberg School of Medicine

Brown University

Career and Research Goals

I plan to pursue a career in academic cardiology centered on heart failure. My current research interests include characterization of potential therapeutic targets for heart failure treatment and heart failure clinical trials.

Fellow Perspective

Tell us briefly about your background before fellowship?
I grew up and went to high school in Connecticut and stayed in New England for my undergraduate education at Brown University. I then moved to Chicago for medical school at Northwestern where I met my wife.  We both stayed at Northwestern for our residencies and she did emergency medicine while I did my internal medicine training.

What are your career plans in cardiology?
I hope to stay in academic medicine with a clinical focus on advanced heart failure and transplantation.

Why did you choose Duke for your fellowship training?
I thought Duke clearly stood out on the interview trail and I felt no other program offered the same combination of clinical exposure and research opportunity. On the clinical side, Duke has high clinical volumes and takes care of the sickest of the sick. The CCU rotation is unique compared to other programs with the fellow having tremendous responsibility for triaging and managing acute MI and cardiogenic shock patients transferred from all across the region (by helicopter or ambulance).  As someone interested in heart failure, I also appreciated the strength of the advanced heart failure faculty, the high volume of heart failure patients, and the close collaboration with CT surgery.  On the research side, I think Duke is unparalleled and the DCRI research fellowship is very unique.  The resources and opportunities for cardiovascular research at Duke continue to amaze me and there is a strong track record of mentorship within all the cardiology subspecialties.

What advice might you offer residents looking at fellowship programs?
Location and family are most important and you have to make sure you have the support in your personal life to thrive in whichever fellowship program you pick. After that, I think it’s helpful to try to imagine your “dream job” 5 years after fellowship. Even if you don’t know the exact subspecialty, try to picture the other facets of the job (i.e., academic vs private practice, relative time in clinic vs inpatient, area of the country, etc). Then try to think of the fellowship program that will best equip you with the tools and relationships to get that job.

From your experience in fellowship, what have you learned about training at Duke?
Duke is a great place to come to work each day. The staff are collaborative and helpful and it is easy to have fun whether on your clinical or research time. I am also lucky to have brilliant and collaborative co-fellows that feed into a feeling of fellowship as a “team sport.”

How is your life in the Triangle area outside of work?
My interview day for cardiology fellowship at Duke was the first time I had ever been to North Carolina! After being in Chicago for the 7 years prior, my wife and I were a little worried about how we might like Durham. Now 3 years later, we can honestly say that we love the area. I really think there is something for everyone (e.g., outdoors activities, great food, sports, shows at the DPAC, etc.) and I like living in a college town and the energy that it brings. It is also very easy to get around and a great place to raise a family.  


Greene, Stephen J., and Robert M. Califf. “Reframing Global Variation in Heart Failure Trials: Thinking Beyond Location on the Map..” Jacc. Heart Failure 7, no. 4 (April 2019): 347–49.

Full Text

Greene, Stephen J., and G Michael Felker. “The Urgency of Doing: Addressing Gaps in Use of Evidence-Based Medical Therapy for Heart Failure..” Jacc Heart Fail 7, no. 1 (January 2019): 22–24.

Full Text

Gori, Mauro, Paolo Canova, Alice Calabrese, Giovanni Cioffi, Roberto Trevisan, Renata De Maria, Aurelia Grosu, et al. “Strategy to identify subjects with diabetes mellitus more suitable for selective echocardiographic screening: The DAVID-Berg study..” International Journal of Cardiology 248 (December 2017): 414–20.

Full Text

Khan, Muhammad Shahzeb, Gregg C. Fonarow, Ali Ahmed, Stephen J. Greene, Muthiah Vaduganathan, Hassan Khan, Catherine Marti, Mihai Gheorghiade, and Javed Butler. “Dose of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Outcomes in Heart Failure: A Meta-Analysis..” Circulation. Heart Failure 10, no. 8 (August 2017).

Full Text

Ambrosy, Andrew P., Ankeet S. Bhatt, Dianne Gallup, Kevin J. Anstrom, Javed Butler, Adam D. DeVore, G Michael Felker, et al. “Trajectory of Congestion Metrics by Ejection Fraction in Patients With Acute Heart Failure (from the Heart Failure Network)..” Am J Cardiol 120, no. 1 (July 1, 2017): 98–105.

Full Text

Greene, Stephen J., Muthiah Vaduganathan, and Mihai Gheorghiade. “Finding the road to recovery: therapeutic and clinical trial implications of dysfunctional viable myocardium in heart failure with reduced ejection fraction..” European Journal of Heart Failure 19, no. 7 (July 2017): 870–72.

Full Text

Greene, Stephen J., Adrian F. Hernandez, Allison Dunning, Andrew P. Ambrosy, Paul W. Armstrong, Javed Butler, Lukasz P. Cerbin, et al. “Hospitalization for Recently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial..” J Am Coll Cardiol 69, no. 25 (June 27, 2017): 3029–39.

Full Text

Senni, Michele, Stephen J. Greene, Javed Butler, Gregg C. Fonarow, and Mihai Gheorghiade. “Drug Development for Heart Failure With Preserved Ejection Fraction: What Pieces Are Missing From the Puzzle?.” The Canadian Journal of Cardiology 33, no. 6 (June 2017): 768–76.

Full Text

Greene, Stephen J., Stephen E. Epstein, Raymond J. Kim, Arshed A. Quyyumi, Robert T. Cole, Allen S. Anderson, Jane E. Wilcox, et al. “Rationale and design of a randomized controlled trial of allogeneic mesenchymal stem cells in patients with nonischemic cardiomyopathy..” J Cardiovasc Med (Hagerstown) 18, no. 4 (April 2017): 283–90.

Full Text

Greene, Stephen J., Gregg C. Fonarow, Scott D. Solomon, Haris P. Subacius, Andrew P. Ambrosy, Muthiah Vaduganathan, Aldo P. Maggioni, et al. “Influence of atrial fibrillation on post-discharge natriuretic peptide trajectory and clinical outcomes among patients hospitalized for heart failure: insights from the ASTRONAUT trial..” European Journal of Heart Failure 19, no. 4 (April 2017): 552–62.

Full Text