Alem W Kahsai, PhD

Publications

Kahsai, Alem W., James W. Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J. Cahill Iii, S Moses Dennison, Dean P. Staus, et al. “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor..” Nat Chem Biol 12, no. 9 (September 2016): 709–16. https://doi.org/10.1038/nchembio.2126.

PMID
27398998
Full Text

Thomsen, Alex R. B., Bianca Plouffe, Thomas J. Cahill, Arun K. Shukla, Jeffrey T. Tarrasch, Annie M. Dosey, Alem W. Kahsai, et al. “GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling..” Cell 166, no. 4 (August 11, 2016): 907–19. https://doi.org/10.1016/j.cell.2016.07.004.

PMID
27499021
Full Text

Staus, Dean P., Ryan T. Strachan, Aashish Manglik, Biswaranjan Pani, Alem W. Kahsai, Tae Hun Kim, Laura M. Wingler, et al. “Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation..” Nature 535, no. 7612 (July 21, 2016): 448–52. https://doi.org/10.1038/nature18636.

PMID
27409812
Full Text

Shukla, Arun K., Gerwin H. Westfield, Kunhong Xiao, Rosana I. Reis, Li-Yin Huang, Prachi Tripathi-Shukla, Jiang Qian, et al. “Visualization of arrestin recruitment by a G-protein-coupled receptor..” Nature 512, no. 7513 (August 14, 2014): 218–22. https://doi.org/10.1038/nature13430.

PMID
25043026
Full Text

Kahsai, Alem W., Sudarshan Rajagopal, Jinpeng Sun, and Kunhong Xiao. “Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry..” Nat Protoc 9, no. 6 (2014): 1301–19. https://doi.org/10.1038/nprot.2014.075.

PMID
24810039
Full Text

Aristotelous, Tonia, Seungkirl Ahn, Arun K. Shukla, Sylwia Gawron, Maria F. Sassano, Alem W. Kahsai, Laura M. Wingler, et al. “Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor..” Acs Med Chem Lett 4, no. 10 (October 10, 2013): 1005–10. https://doi.org/10.1021/ml400312j.

PMID
24454993
Full Text

Wang, J., A. Seungkirl, A. W. Kahsai, R. Liu, J. Ren, K. Hu, X. Sun, and X. Chen. “Synthesis of β2-AR agonist BI-167107.” Chinese Journal of Organic Chemistry 33, no. 3 (March 1, 2013): 634–39. https://doi.org/10.6023/cjoc201211015.

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Kahsai, Alem W., Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K. Shukla, Jinpeng Sun, Terrence G. Oas, and Robert J. Lefkowitz. “Multiple ligand-specific conformations of the β2-adrenergic receptor..” Nat Chem Biol 7, no. 10 (August 21, 2011): 692–700. https://doi.org/10.1038/nchembio.634.

PMID
21857662
Full Text

Knecht, David A., Rebecca A. LaFleur, Alem W. Kahsai, Christian E. Argueta, Anwar B. Beshir, and Gabriel Fenteany. “Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics..” Plos One 5, no. 11 (November 24, 2010). https://doi.org/10.1371/journal.pone.0014039.

PMID
21124831
Full Text

Kahsai, Alem W., Shoutian Zhu, and Gabriel Fenteany. “G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells..” Biochim Biophys Acta 1803, no. 2 (February 2010): 300–310. https://doi.org/10.1016/j.bbamcr.2009.11.002.

PMID
19913059
Full Text

Pages