Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Mendrick, Donna L., Anna Mae Diehl, Lisa S. Topor, Rodney R. Dietert, Yvonne Will, Michele A. La Merrill, Sebastien Bouret, et al. “Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic..” Toxicol Sci 162, no. 1 (March 1, 2018): 36–42. https://doi.org/10.1093/toxsci/kfx233.

PMID
29106690
Full Text

Loomba, Rohit, Eric Lawitz, Parvez S. Mantry, Saumya Jayakumar, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial..” Hepatology 67, no. 2 (February 2018): 549–59. https://doi.org/10.1002/hep.29514.

PMID
28892558
Full Text

Loomba, Rohit, Yevgeniy Gindin, Zhaoshi Jiang, Eric Lawitz, Stephen Caldwell, C Stephen Djedjos, Ren Xu, et al. “DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis..” Jci Insight 3, no. 2 (January 25, 2018). https://doi.org/10.1172/jci.insight.96685.

PMID
29367468
Full Text

Wegermann, Kara, Ricardo Henao, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, and Cynthia A. Moylan. “Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study..” Plos One 13, no. 9 (January 2018). https://doi.org/10.1371/journal.pone.0204308.

PMID
30265706
Full Text

Wang, Sihyung, Youngmi Jung, Jeongeun Hyun, Matthew Friedersdorf, Seh-Hoon Oh, Jieun Kim, Richard T. Premont, Jack D. Keene, and Anna Mae Diehl. “RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts..” Cell Physiol Biochem 48, no. 3 (2018): 1215–29. https://doi.org/10.1159/000491987.

PMID
30045014
Full Text

Diehl, Anna M., and Christopher Day. “Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis..” N Engl J Med 377, no. 21 (November 23, 2017): 2063–72. https://doi.org/10.1056/NEJMra1503519.

PMID
29166236
Full Text

Chandrashekaran, Varun, Ratanesh K. Seth, Diptadip Dattaroy, Firas Alhasson, Jacek Ziolenka, James Carson, Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, and Saurabh Chatterjee. “HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease..” Redox Biol 13 (October 2017): 8–19. https://doi.org/10.1016/j.redox.2017.05.005.

PMID
28551086
Full Text

Chen, Jiamei, Long Chen, Mark A. Zern, Neil D. Theise, Ann Mae Diehl, Ping Liu, and Yuyou Duan. “The diversity and plasticity of adult hepatic progenitor cells and their niche..” Liver Int 37, no. 9 (September 2017): 1260–71. https://doi.org/10.1111/liv.13377.

PMID
28135758
Full Text

Pages