Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Joel E. Lavine, Katherine Yates, Jagpal Klair, et al. “Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis..” Clin Gastroenterol Hepatol 15, no. 1 (January 2017): 127-131.e2. https://doi.org/10.1016/j.cgh.2016.07.034.

PMID
27523635
Full Text

Seth, Ratanesh K., Suvarthi Das, Diptadip Dattaroy, Varun Chandrashekaran, Firas Alhasson, Gregory Michelotti, Mitzi Nagarkatti, et al. “TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity..” Free Radic Biol Med 102 (January 2017): 260–73. https://doi.org/10.1016/j.freeradbiomed.2016.11.047.

PMID
27913210
Full Text

Loomba, Rohit, Eric Lawitz, Parvez S. Mantry, Saumya Jaya-kumar, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “GS-4997, an Inhibitor of Apoptosis Signal-Regulating Kinase (ASK1), Alone or in Combination with Simtuzumab for the Treatment of Nonalcoholic Steatohepatitis (NASH): A Randomized, Phase 2 Trial.” In Hepatology, 64:1119A-1120A. WILEY, 2016.

Scholars@Duke

Pereira, Thiago Almeida, Wing-Kin Syn, Fausto E. L. Pereira, José Roberto Lambertucci, William Evan Secor, and Anna Mae Diehl. “Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni..” Int J Parasitol 46, no. 13–14 (December 2016): 829–32. https://doi.org/10.1016/j.ijpara.2016.08.004.

PMID
27729270
Full Text

Nelson, J. E., P. Handa, B. Aouizerat, L. Wilson, L. A. Vemulakonda, M. M. Yeh, K. V. Kowdley, and K. V. NASH Clinical Research Network. “Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms..” Aliment Pharmacol Ther 44, no. 11–12 (December 2016): 1253–64. https://doi.org/10.1111/apt.13824.

PMID
27730688
Full Text

Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis..” Am J Gastroenterol 111, no. 11 (November 2016): 1591–98. https://doi.org/10.1038/ajg.2016.406.

PMID
27644736
Full Text

Seth, Ratanesh K., Diptadip Dattaroy, Varun Chandrashekaran, Suvarthi Das, Firas Alhasson, Marcelo G. Bonini, Gregory A. Michelotti, et al. “TRPV4 prevents tissue injury in diseased fatty liver by blocking CYP2E1-mediated redox-toxicity via Kupffer cell-induced nitric oxide production.” In Hepatology, 64:793A-794A. WILEY, 2016.

Scholars@Duke

Coombes, Jason D., Paul P. Manka, Marzena Swiderska-Syn, Danielle Reid, Antonio Riva, Lee C. Claridge, Laurent Dolle, et al. “Cholangiocyte chemokine secretion and macrophage accumulation is mediated by osteopontin in murine liver models.” In Hepatology, 64:89A-90A. WILEY, 2016.

Scholars@Duke

Swiderska-Syn, Marzena, Guanhua Xie, and Anna Mae Diehl. “Hedgehog-responsive Myofibroblasts activate Yes-associated Protein (Yap) 1 and Promote TGFb-Signaling to Induce Epithelial-Mesenchymal Transitions in Hepatocytes during Murine Liver Regeneration.” In Hepatology, 64:835A-836A. WILEY, 2016.

Scholars@Duke

Premont, Richard T., Marzena Swiderska-Syn, Mark Jewell, and Anna Mae Diehl. “Hepatic stellate cell Yes-associated protein 1 (Yap1) is necessary for liver regeneration.” In Hepatology, 64:837A-837A. WILEY, 2016.

Scholars@Duke

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