Anna Mae Diehl, MD

Professor of Medicine
Florence McAlister Professor of Medicine, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone (919) 684-2366
Email address diehl004@mc.duke.edu

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Johns Hopkins University, 1981 - 1984
  • Medical Resident, Medicine, Johns Hopkins University, 1978 - 1981
  • M.D., Georgetown University, 1978

Publications

Loomba, Rohit, Eric Lawitz, Parvez S. Mantry, Saumya Jaya-kumar, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “GS-4997, an Inhibitor of Apoptosis Signal-Regulating Kinase (ASK1), Alone or in Combination with Simtuzumab for the Treatment of Nonalcoholic Steatohepatitis (NASH): A Randomized, Phase 2 Trial.” In Hepatology, 64:1119A-1120A. WILEY, 2016.

Scholars@Duke

Loomba, Rohit, Eric Lawitz, Parvez S. Mantry, Saumya Jaya-kumar, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “GS-4997, an Inhibitor of Apoptosis Signal-Regulating Kinase (ASK1), Alone or in Combination with Simtuzumab for the Treatment of Nonalcoholic Steatohepatitis (NASH): A Randomized, Phase 2 Trial.” In Hepatology, 64:1119A-1120A. WILEY, 2016.

Scholars@Duke

Pereira, Thiago Almeida, Wing-Kin Syn, Fausto E. L. Pereira, José Roberto Lambertucci, William Evan Secor, and Anna Mae Diehl. “Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni..” International Journal for Parasitology 46, no. 13–14 (December 2016): 829–32. https://doi.org/10.1016/j.ijpara.2016.08.004.

PMID
27729270
Full Text

Nelson, J. E., P. Handa, B. Aouizerat, L. Wilson, L. A. Vemulakonda, M. M. Yeh, K. V. Kowdley, and K. V. NASH Clinical Research Network. “Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms..” Alimentary Pharmacology & Therapeutics 44, no. 11–12 (December 2016): 1253–64. https://doi.org/10.1111/apt.13824.

PMID
27730688
Full Text

Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis..” The American Journal of Gastroenterology 111, no. 11 (November 2016): 1591–98. https://doi.org/10.1038/ajg.2016.406.

PMID
27644736
Full Text

Pereira, Thiago Almeida, Wing-Kin Syn, Frederico Figueiredo Amâncio, Pedro Henrique Diniz Cunha, Julia Fonseca Morais Caporali, Guilherme Vaz de Melo Trindade, Elisângela Trindade Santos, et al. “Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni..” Plos Neglected Tropical Diseases 10, no. 10 (October 18, 2016). https://doi.org/10.1371/journal.pntd.0005057.

PMID
27755536
Full Text

Swiderska-Syn, Marzena, Guanhua Xie, and Anna Mae Diehl. “Hedgehog-responsive Myofibroblasts activate Yes-associated Protein (Yap) 1 and Promote TGFb-Signaling to Induce Epithelial-Mesenchymal Transitions in Hepatocytes during Murine Liver Regeneration.” In Hepatology, 64:835A-836A. WILEY, 2016.

Scholars@Duke

Swiderska-Syn, Marzena, Guanhua Xie, and Anna Mae Diehl. “Hedgehog-responsive Myofibroblasts activate Yes-associated Protein (Yap) 1 and Promote TGFb-Signaling to Induce Epithelial-Mesenchymal Transitions in Hepatocytes during Murine Liver Regeneration.” In Hepatology, 64:835A-836A. WILEY, 2016.

Scholars@Duke

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