Augustus Oliver Grant, MBBCh, PhD

Professor of Medicine
Vice Dean, for Faculty Enrichment
Campus mail 2301 Erwin Road, 7th Floor, Room #7407, Durham, NC 27710
Phone (919) 684-3901
Email address grant007@mc.duke.edu

This laboratory seeks to understand the molecular events that control excitation in cardiac muscle and the mechanisms by which excitation is modified by drugs. The experimental models include the isolated cardiac myocyte, the frog oocyte and mammalian cells expressing mRNA transcripts of wild-type and mutant channels. The experimental techniques include DNA and RNA manipulation, whole cell voltage clamping and the extracellular patch clamping. The current focus of the laboratory is the voltage gated sodium channel. The problems under study include:

1) The functional effects of the derangements occurring during
myocardial ischemia on channel function.
2) The mechanisms of blockade of channels by antiarrhythmic drugs.
3) The relationship between channel structure and antiarrhythmic drug
binding.
4) The development of models to describe the interaction of anti-
arrhythmic drugs with membrane channels.

These studies should provide a clearer understanding of the cellular basis of cardiac arrhythmias and the mechanisms by which they are terminated by drug.

In Their Words

Education and Training

  • Ph.D., University of California at Los Angeles, 1975
  • M.B.B.Ch., University of Edinburgh (Scotland), 1971

Publications

Black-Maier, E, Ren, X, Steinberg, BA, Green, CL, Barnett, AS, Rosa, NS, Al-Khatib, SM, Atwater, BD, Daubert, JP, Frazier-Mills, C, Grant, AO, Hegland, DD, Jackson, KP, Jackson, LR, Koontz, JI, Lewis, RK, Sun, AY, Thomas, KL, Bahnson, TD, and Piccini, JP. "Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction." Heart rhythm (December 5, 2017).

PMID
29222043
Full Text

Black-Maier, EW, Pokorney, SD, Barnett, AS, Liu, P, Shrader, P, Ng, J, Goldberger, JJ, Zareba, W, Daubert, JP, Grant, AO, and Piccini, JP. "Ranolazine reduces atrial fibrillatory wave frequency." Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 19, no. 7 (July 2017): 1096-1100.

PMID
27756767
Full Text

Daubert, JP, Grant, AO, and Jr, KRN. "Novel insights into beta-blocker therapy for long QT syndromes." Journal of the American College of Cardiology 60, no. 20 (2012): 2100-2101.

PMID
23083777
Full Text

Wang, Y, Chandra, R, Samsa, LA, Gooch, B, Fee, BE, Cook, JM, Vigna, SR, Grant, AO, and Liddle, RA. "Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor." Am J Physiol Gastrointest Liver Physiol 300, no. 4 (April 2011): G528-G537.

PMID
21183662
Full Text

Grant, AO. "Basic Electrophysiology." Cardiac Electrophysiology Clinics 2, no. 3 (2010): 325-340.

PMID
28770793
Full Text

Grant, AO. "Cardiac ion channels." Circ Arrhythm Electrophysiol 2, no. 2 (April 2009): 185-194. (Review)

PMID
19808464
Full Text

Grant, AO. "The variability of the electrical properties of the pulmonary veins." Journal of Cardiovascular Electrophysiology 20, no. 9 (2009): 1046-1047.

PMID
19572950
Full Text

Nilsson, KR, Sewell, PM, Blunden-Kasdorf, P, Starkey, K, Grant, AO, and Wagner, GS. "The influence of cardiograph design and automated algorithms on the incidence and detection of electrode cable reversals in an academic electrocardiogram laboratory." J Electrocardiol 41, no. 5 (September 2008): 382-387.

PMID
18721645
Full Text

Thomas, K, and Grant, AO. "Ethnicity and arrhythmia susceptibility." Journal of Cardiovascular Electrophysiology 19, no. 4 (2008): 427-429.

PMID
18284497
Full Text

Zhang, Z-S, Tranquillo, J, Neplioueva, V, Bursac, N, and Grant, AO. "Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease." Am J Physiol Heart Circ Physiol 292, no. 1 (January 2007): H399-H407.

PMID
16877553
Full Text

Pages