Barry Raymond Stripp, PhD

Adjunct Professor in the Department of Medicine
Campus mail 2075 Medical Science Research, Box 103000, Durham, NC 27710
Phone (919) 668-7762
Email address barry.stripp@duke.edu

Dr. Stripp’s research interests focus on understanding cellular and molecular mechanisms of lung injury and repair. Defects in the maintenance and differentiation of epithelia lining small airways are commonly observed in chronic lung disease and represent a therapeutic target for interventions aimed at restoring lung function. His laboratory has defined microenvironments within bronchiolar airways that maintain a population of adult tissue stem cells. Current research is aimed at understanding the molecular regulation of the bronchiolar stem cell hierarchy. Signaling mediated by conditional stabilization of β-catenin was found to expand the pool of lung stem cells in vivo. Future studies are aimed at understanding molecular mechanisms by which stabilized β-catenin regulate the stem cell compartment and to exploit this strategy for development of cell and molecular therapies to correct epithelial reparative disorders. Related studies in Dr. Stripp’s laboratory are investigating Clara cell-macrophage interactions involved in regulation of lung inflammatory responses. These studies again relate to the observation that Clara cell secretory function is compromised in the setting of chronic inflammatory lung diseases. Recent findings demonstrate a role for Clara cell secretions in the modulation of endotoxin-elicited TNF-α release by lung macrophages

Education and Training

  • Ph.D., East Carolina University, 1989

Publications

Kelly, F. L., V. E. Kennedy, R. Jain, N. S. Sindhwani, C. A. Finlen Copeland, L. D. Snyder, J. P. Eu, et al. “Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation..” Am J Transplant 12, no. 11 (November 2012): 3076–84. https://doi.org/10.1111/j.1600-6143.2012.04201.x.

PMID
22883104
Full Text

Manzo, Nicholas D., W Michael Foster, and Barry R. Stripp. “Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury..” Am J Respir Cell Mol Biol 47, no. 3 (September 2012): 349–57. https://doi.org/10.1165/rcmb.2011-0257OC.

PMID
22493011
Full Text

Chen, Huaiyong, Keitaro Matsumoto, Brian L. Brockway, Craig R. Rackley, Jiurong Liang, Joo-Hyeon Lee, Dianhua Jiang, et al. “Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury..” Stem Cells 30, no. 9 (September 2012): 1948–60. https://doi.org/10.1002/stem.1150.

PMID
22696116
Full Text

Rackley, Craig R., and Barry R. Stripp. “Building and maintaining the epithelium of the lung..” J Clin Invest 122, no. 8 (August 2012): 2724–30. https://doi.org/10.1172/JCI60519.

PMID
22850882
Full Text

Hashimoto, Shuichi, Huaiyong Chen, Jianwen Que, Brian L. Brockway, Jeffrey A. Drake, Joshua C. Snyder, Scott H. Randell, and Barry R. Stripp. “β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium..” J Cell Sci 125, no. Pt 4 (February 15, 2012): 932–42. https://doi.org/10.1242/jcs.092734.

PMID
22421361
Full Text

Sountoulidis, Alexandros, Athanasios Stavropoulos, Stavros Giaglis, Eirini Apostolou, Rui Monteiro, Susana M. Chuva de Sousa Lopes, Huaiyong Chen, et al. “Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair..” Plos One 7, no. 8 (2012). https://doi.org/10.1371/journal.pone.0041460.

PMID
22916109
Full Text

Lukinskiene, Lina, Yang Liu, Susan D. Reynolds, Chad Steele, Barry R. Stripp, George D. Leikauf, Jay K. Kolls, and Y Peter Di. “Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection..” J Immunol 187, no. 1 (July 1, 2011): 382–90. https://doi.org/10.4049/jimmunol.1001769.

PMID
21632717
Full Text

Lindsey, James Y., Koustav Ganguly, David M. Brass, Zhuowei Li, Erin N. Potts, Simone Degan, Huaiyong Chen, et al. “c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice..” Am J Respir Crit Care Med 183, no. 12 (June 15, 2011): 1644–52. https://doi.org/10.1164/rccm.201007-1157OC.

PMID
21471107
Full Text

Teisanu, Roxana M., Huaiyong Chen, Keitaro Matsumoto, Jonathan L. McQualter, Erin Potts, W Michael Foster, Ivan Bertoncello, and Barry R. Stripp. “Functional analysis of two distinct bronchiolar progenitors during lung injury and repair..” Am J Respir Cell Mol Biol 44, no. 6 (June 2011): 794–803. https://doi.org/10.1165/rcmb.2010-0098OC.

PMID
20656948
Full Text

Weiss, Daniel J., Ivan Bertoncello, Zea Borok, Carla Kim, Angela Panoskaltsis-Mortari, Susan Reynolds, Mauricio Rojas, Barry Stripp, David Warburton, and Darwin J. Prockop. “Stem cells and cell therapies in lung biology and lung diseases..” Proc Am Thorac Soc 8, no. 3 (June 2011): 223–72. https://doi.org/10.1513/pats.201012-071DW.

PMID
21653527
Full Text

Pages