Bruce Lobaugh, PhD

Professor in Pathology
Associate Professor in Medicine
Campus mail 133D Clin & Res Labs, Durham, NC 27710
Phone (919) 681-6335
Email address bruce.lobaugh@duke.edu

The overall objective of my research is to characterize the mechanisms by which mineral homeostasis is achieved and skeletal integrity maintained in vertebrate species. This knowledge can then be applied to specific diseases to pinpoint pathogenic mechanisms and develop therapeutic strategies. Current areas of emphasis include:

· Regulation of vitamin D metabolism during pregnancy and lactation.
Using new assays for renal vitamin D hvdroxylase activities, "free" 1,25-
dihydroxyvitamin D and metabolic turnover of 1,25-dihydroxyvitamin D, we are investigating the regulation of this vitamin D hormone during pregnancy
and lactation. Results from these studies will supplement our existing data
on the mechanisms governing day-to-day regulation of vitamin D
metabolism and may yield insight into these processes during periods of special demand.

· Development of an animal model of human primary hyperparathyroidism.
Studies are ongoing to produce and fully characterize a murine model of human primary hyperparathyroidism (HPT). When rice-grain sized slivers of human parathyroid adenoma explants are inserted into gluteal pockets of athymic nude mice, persistent hypercalcemia and hypophosphatemia (>6 months duration) develop within several days in a percentage of the animals. Moreover, biosynthesis of 1, 25-dihydroxyvitamin D, a key hormone whose activation is modulated by parathyroid hormone (PTH), is also chronically stimulated. This model will allow: 1) study of the relationships between HPT and other conditions commonly associated with the disorder (e.g. hypertension, peptic ulcer disease, renal stones); 2) the regulation of vitamin D metabolism in HPT; 3) the natural history of bone disease in HPT; and 4) new nonsurgical techniques to localize and treat HPT.

Special areas of expertise include skeletal and mineral homeostasis, biometry, continuous quality improvement and clinical laboratory administration.

Key Words: calcium, phosphorus, Vitamin D, hyperparathyroidism, lactation, endocrinology

Education and Training

  • Ph.D., Pennsylvania State University, 1981
  • M.S., Pennsylvania State University, 1978
  • B.S., Clarion University, 1975

Publications

Hoyo, C, Grubber, J, Demark-Wahnefried, W, Lobaugh, B, Jeffreys, AS, Grambow, SC, Marks, JR, Keku, TO, Walther, PJ, and Schildkraut, JM. "Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men." J Natl Med Assoc 101, no. 7 (July 2009): 711-716.

PMID
19634593
Scholars@Duke

Whitson, HE, Lobaugh, B, and Lyles, KW. "Severe hypocalcemia following bisphosphonate treatment in a patient with Paget's disease of bone." Bone 39, no. 4 (October 2006): 954-958.

PMID
16769264
Full Text

Hiatt, RA, Krieger, N, Lobaugh, B, Drezner, MK, Vogelman, JH, and Orentreich, N. "Prediagnostic serum vitamin D and breast cancer." J Natl Cancer Inst 90, no. 6 (March 18, 1998): 461-463.

PMID
9521171
Scholars@Duke

Feinglos, MN, Thacker, CR, Lobaugh, B, DeAtkine, DD, McNeill, DB, English, JS, and Bursey, DL. "Combination insulin and sulfonylurea therapy in insulin-requiring type 2 diabetes mellitus." Diabetes Res Clin Pract 39, no. 3 (March 1998): 193-199.

PMID
9649951
Scholars@Duke

Demark-Wahnefried, W, Lesko, SM, Conaway, MR, Robertson, CN, Clark, RV, Lobaugh, B, Mathias, BJ, Strigo, TS, and Paulson, DF. "Serum androgens: associations with prostate cancer risk and hair patterning." J Androl 18, no. 5 (September 1997): 495-500.

PMID
9349747
Scholars@Duke

Alahari, KD, Lobaugh, B, and Econs, MJ. "Vitamin D receptor alleles do not correlate with bone mineral density in premenopausal Caucasian women from the southeastern United States." Metabolism 46, no. 2 (February 1997): 224-226.

PMID
9030833
Scholars@Duke

Quarles, LD, Yohay, DA, Carroll, BA, Spritzer, CE, Minda, SA, Bartholomay, D, and Lobaugh, BA. "Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD." Kidney Int 45, no. 6 (June 1994): 1710-1721.

PMID
7933819
Scholars@Duke

Myers, BS, Arbogast, KB, Lobaugh, B, Harper, KD, Richardson, WJ, and Drezner, MK. "Improved assessment of lumbar vertebral body strength using supine lateral dual-energy x-ray absorptiometry." J Bone Miner Res 9, no. 5 (May 1994): 687-693.

PMID
8053398
Full Text

Freedman, SF, Freedman, NJ, Shields, MB, Lobaugh, B, Samsa, GP, Keates, EU, and Ollie, A. "Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level." Am J Ophthalmol 116, no. 5 (November 15, 1993): 600-611.

PMID
8238221
Scholars@Duke

Corder, EH, Guess, HA, Hulka, BS, Friedman, GD, Sadler, M, Vollmer, RT, Lobaugh, B, Drezner, MK, Vogelman, JH, and Orentreich, N. "Vitamin D and prostate cancer: a prediagnostic study with stored sera." Cancer Epidemiol Biomarkers Prev 2, no. 5 (September 1993): 467-472.

PMID
8220092
Scholars@Duke

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