Christopher Dale Kontos, MD

Professor of Medicine
Director, Medical Scientist Training Program
Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 435 Sands Bldg, Durham, NC 27710
Phone (919) 684-2119
Email address cdkontos@duke.edu

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1993 - 1997
  • M.D., Virginia Commonwealth University, 1989

Publications

Xie, D, Findley, CM, Greenfield, JM, Pippen, AM, Kontos, CD, Donatucci, CF, and Annex, BH. "A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits." J Sex Med 5, no. 9 (September 2008): 2069-2078.

PMID
18637998
Full Text

Findley, CM, Mitchell, RG, Duscha, BD, Annex, BH, and Kontos, CD. "Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease." J Am Coll Cardiol 52, no. 5 (July 29, 2008): 387-393.

PMID
18652948
Full Text

Sarraf-Yazdi, S, Mi, J, Moeller, BJ, Niu, X, White, RR, Kontos, CD, Sullenger, BA, Dewhirst, MW, and Clary, BM. "Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer." J Surg Res 146, no. 1 (May 1, 2008): 16-23.

PMID
17950331
Full Text

Xie, D, Hazarika, S, Andrich, AJ, Padgett, ME, Kontos, CD, Donatucci, CF, and Annex, BH. "High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue." J Sex Med 5, no. 5 (May 2008): 1137-1148.

PMID
18439153
Full Text

Mi, J, Zhang, X, Rabbani, ZN, Liu, Y, Reddy, SK, Su, Z, Salahuddin, FK, Viles, K, Giangrande, PH, Dewhirst, MW, Sullenger, BA, Kontos, CD, and Clary, BM. "RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin." Mol Ther 16, no. 1 (January 2008): 66-73.

PMID
17912235
Full Text

White, RR, Roy, JA, Viles, KD, Sullenger, BA, and Kontos, CD. "A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function." Angiogenesis 11, no. 4 (2008): 395-401.

PMID
19037734
Full Text

Findley, CM, Cudmore, MJ, Ahmed, A, and Kontos, CD. "VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling." Arterioscler Thromb Vasc Biol 27, no. 12 (December 2007): 2619-2626.

PMID
17901375
Full Text

Hazarika, S, Dokun, AO, Li, Y, Popel, AS, Kontos, CD, and Annex, BH. "Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1." Circ Res 101, no. 9 (October 26, 2007): 948-956.

PMID
17823371
Full Text

Cao, Y, Sonveaux, P, Liu, S, Zhao, Y, Mi, J, Clary, BM, Li, C-Y, Kontos, CD, and Dewhirst, MW. "Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth." Cancer Res 67, no. 8 (April 15, 2007): 3835-3844.

PMID
17440098
Full Text

Kontos, CD, and Annex, BH. "Engineered transcription factors for therapeutic angiogenesis." Curr Opin Mol Ther 9, no. 2 (April 2007): 145-152. (Review)

PMID
17458168
Scholars@Duke

Pages