Christopher Dale Kontos, MD

Professor of Medicine
Director, Medical Scientist Training Program
Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 435 Sands Bldg, Durham, NC 27710
Phone (919) 684-2119
Email address cdkontos@duke.edu

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1993 - 1997
  • M.D., Virginia Commonwealth University, 1989

Publications

Xie, D, Kontos, CD, Donatucci, CF, and Annex, BH. "Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues." The Journal of Sexual Medicine 2, no. 5 (September 2005): 634-640.

PMID
16422820
Full Text

Singh, N, Macnamara, E, Rashid, S, Ambati, J, Kontos, CD, Higgins, E, and Ambati, BK. "Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization." Biochem Biophys Res Commun 332, no. 1 (June 24, 2005): 194-199.

PMID
15896317
Full Text

Hata, JA, Petrofski, JA, Schroder, JN, Williams, ML, Timberlake, SH, Pippen, A, Corwin, MT, Solan, AK, Jakoi, A, Gehrig, TR, Kontos, CD, and Milano, CA. "Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts." The Journal of Thoracic and Cardiovascular Surgery 129, no. 6 (June 2005): 1405-1413.

PMID
15942585
Full Text

Sanchez, T, Thangada, S, Wu, M-T, Kontos, CD, Wu, D, Wu, H, and Hla, T. "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor." Proceedings of the National Academy of Sciences of the United States of America 102, no. 12 (March 11, 2005): 4312-4317.

PMID
15764699
Full Text

Huang, J, Niu, X-L, Pippen, AM, Annex, BH, and Kontos, CD. "Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia." Arterioscler Thromb Vasc Biol 25, no. 2 (February 2005): 354-358.

PMID
15569824
Full Text

Xie, D, Kontos, CD, Donatucci, CF, and Annex, BH. "Erratum: Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues (Journal of Sexual Medicine (2005) 2 (634-640))." Journal of Sexual Medicine 2, no. 6 (2005): 876--.

Full Text

Khan, A, Ashrafpour, H, Huang, N, Neligan, PC, Kontos, C, Zhong, A, Forrest, CR, and Pang, CY. "Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 287, no. 5 (November 2004): R1219-R1229.

PMID
15217788
Full Text

Dai, Q, Huang, J, Klitzman, B, Dong, C, Goldschmidt-Clermont, PJ, March, KL, Rokovich, J, Johnstone, B, Rebar, EJ, Spratt, SK, Case, CC, Kontos, CD, and Annex, BH. "Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia." Circulation 110, no. 16 (October 19, 2004): 2467-2475.

PMID
15477407
Full Text

Yamaoka-Tojo, M, Ushio-Fukai, M, Hilenski, L, Dikalov, SI, Chen, YE, Tojo, T, Fukai, T, Fujimoto, M, Patrushev, NA, Wang, N, Kontos, CD, Bloom, GS, and Alexander, RW. "IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation." Circulation Research 95, no. 3 (August 2004): 276-283.

PMID
15217908
Full Text

Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." FASEB JOURNAL 18, no. 2 (February 2004): 326-328.

Full Text

Pages