Christopher Vine Plowe, MD

Professor of Medicine
Director, Duke Global Health Institute
Research Professor of Global Health
Professor in the Department of Molecular Genetics and Microbiology
Email address chris.plowe@duke.edu

Education and Training

  • Clinical Infectious Diseases Fellowship, Medicine, Johns Hopkins University School of Medicine, 1994 - 1995
  • Clinical & Research Associate, NIAID, Laboratory Of Malaria Research, National Institutes of Health, 1991 - 1994
  • Internal Medicine Chief Resident, Columbia University College of Physicians and Surgeons, 1990 - 1991
  • International Fellows Program, Columbia University College of Physicians and Surgeons, 1989 - 1990
  • Internal Medicine Internship and Residency, Columbia University, 1986 - 1989
  • M.P.H., Columbia University, 1991
  • M.D., Weill Cornell Medical College, 1986

Publications

Cortese, J. F., and C. V. Plowe. “Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast..” Mol Biochem Parasitol 94, no. 2 (August 1, 1998): 205–14. https://doi.org/10.1016/s0166-6851(98)00075-9.

PMID
9747971
Full Text

Kublin, J. G., R. S. Witzig, A. H. Shankar, J. Q. Zurita, R. H. Gilman, J. A. Guarda, J. F. Cortese, and C. V. Plowe. “Molecular assays for surveillance of antifolate-resistant malaria..” Lancet 351, no. 9116 (May 30, 1998): 1629–30. https://doi.org/10.1016/S0140-6736(98)24022-0.

PMID
9620719
Full Text

Nzila-Mounda, A., E. K. Mberu, C. H. Sibley, C. V. Plowe, P. A. Winstanley, and W. M. Watkins. “Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain..” Antimicrob Agents Chemother 42, no. 1 (January 1998): 164–69.

PMID
9449279
Scholars@Duke

Perry, R. T., C. V. Plowe, B. Koumaré, F. Bougoudogo, K. L. Kotloff, G. A. Losonsky, S. S. Wasserman, and M. M. Levine. “A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali..” Bull World Health Organ 76, no. 1 (1998): 63–71.

PMID
9615498
Scholars@Duke

Plowe, C. V., J. F. Cortese, A. Djimde, O. C. Nwanyanwu, W. M. Watkins, P. A. Winstanley, J. G. Estrada-Franco, et al. “Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance..” J Infect Dis 176, no. 6 (December 1997): 1590–96. https://doi.org/10.1086/514159.

PMID
9395372
Full Text

Watkins, W. M., E. K. Mberu, P. A. Winstanley, and C. V. Plowe. “The efficacy of antifolate antimalarial combinations in Africa: A predictive model based on pharmacodynamic and pharmacokinetic analyses.” Parasitology Today 13, no. 12 (January 1, 1997): 459–64.

Scholars@Duke

Plowe, C. V., A. Djimde, T. E. Wellems, S. Diop, B. Kouriba, and O. K. Doumbo. “Community pyrimethamine-sulfadoxine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: a model for deterring resistance..” Am J Trop Med Hyg 55, no. 5 (November 1996): 467–71. https://doi.org/10.4269/ajtmh.1996.55.467.

PMID
8940973
Full Text

Plowe, C. V., A. Djimde, M. Bouare, O. Doumbo, and T. E. Wellems. “Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa..” Am J Trop Med Hyg 52, no. 6 (June 1995): 565–68. https://doi.org/10.4269/ajtmh.1995.52.565.

PMID
7611566
Full Text

Vaidya, A. B., J. Morrisey, C. V. Plowe, D. C. Kaslow, and T. E. Wellems. “Unidirectional dominance of cytoplasmic inheritance in two genetic crosses of Plasmodium falciparum..” Mol Cell Biol 13, no. 12 (December 1993): 7349–57. https://doi.org/10.1128/mcb.13.12.7349.

PMID
8246955
Full Text

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