Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Hampson, NB, Piantadosi, CA, Thom, SR, and Weaver, LK. "Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning." American Journal of Respiratory and Critical Care Medicine 186, no. 11 (December 2012): 1095-1101.

PMID
23087025
Full Text

Piantadosi, CA, and Suliman, HB. "Redox regulation of mitochondrial biogenesis." Free Radical Biology & Medicine 53, no. 11 (December 2012): 2043-2053. (Review)

PMID
23000245
Full Text

Chen, Y, Choi, SS, Michelotti, GA, Chan, IS, Swiderska-Syn, M, Karaca, GF, Xie, G, Moylan, CA, Garibaldi, F, Premont, R, Suliman, HB, Piantadosi, CA, and Diehl, AM. "Hedgehog controls hepatic stellate cell fate by regulating metabolism." Gastroenterology 143, no. 5 (November 2012): 1319-1329.e11.

PMID
22885334
Full Text

Athale, J, Ulrich, A, MacGarvey, NC, Bartz, RR, Welty-Wolf, KE, Suliman, HB, and Piantadosi, CA. "Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice." Free Radical Biology & Medicine 53, no. 8 (October 2012): 1584-1594.

PMID
22940620
Full Text

Radiloff, DR, Zhao, Y, Boico, A, Wu, C, Shan, S, Palmer, G, Hamilton, K, Irwin, D, Hanna, G, Piantadosi, CA, and Schroeder, T. "The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude." Journal of Applied Physiology (Bethesda, Md. : 1985) 113, no. 8 (October 2012): 1243-1252.

PMID
22898548
Full Text

Torp, KD, Carraway, MS, Ott, MC, Stolp, BW, Moon, RE, Piantadosi, CA, and Freiberger, JJ. "Safe administration of hyperbaric oxygen after bleomycin: a case series of 15 patients." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 39, no. 5 (September 2012): 873-879.

PMID
23045915
Scholars@Duke

Piantadosi, CA. "Mitochondrial biogenesis: CO and NO too." July 15, 2012.

Full Text

Demchenko, IT, Mahon, RT, Allen, BW, and Piantadosi, CA. "Brain oxygenation and CNS oxygen toxicity after infusion of perfluorocarbon emulsion." J Appl Physiol (1985) 113, no. 2 (July 2012): 224-231.

PMID
22556400
Full Text

Freiberger, JJ, Padilla-Burgos, R, McGraw, T, Suliman, HB, Kraft, KH, Stolp, BW, Moon, RE, and Piantadosi, CA. "What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics." Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons 70, no. 7 (July 2012): 1573-1583.

PMID
22698292
Full Text

Piantadosi, CA. "Regulation of mitochondrial processes by protein S-nitrosylation." Biochimica Et Biophysica Acta 1820, no. 6 (June 2012): 712-721. (Review)

PMID
21397666
Full Text

Pages