Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Demchenko, IT, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O₂ toxicity." Journal of Applied Physiology (Bethesda, Md. : 1985) 112, no. 11 (June 2012): 1814-1823.

PMID
22442027
Full Text

Piantadosi, CA, Bartz, RR, Carraway, MS, Ghio, AJ, McMahon, TJ, Murdoch, DM, Roggli, VL, Shofer, SL, Tighe, RM, Welty-Wolf, KE, and Young, SL. "The opprobrium of Big Tobacco." Am J Respir Crit Care Med 185, no. 9 (May 1, 2012): 1030-. (Letter)

PMID
22550218
Full Text

Badea, CT, Guo, X, Clark, D, Johnston, SM, Marshall, CD, and Piantadosi, CA. "Dual-energy micro-CT of the rodent lung." American Journal of Physiology. Lung Cellular and Molecular Physiology 302, no. 10 (May 2012): L1088-L1097.

PMID
22427526
Full Text

MacGarvey, NC, Suliman, HB, Bartz, RR, Fu, P, Withers, CM, Welty-Wolf, KE, and Piantadosi, CA. "Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis." American Journal of Respiratory and Critical Care Medicine 185, no. 8 (April 2012): 851-861.

PMID
22312014
Full Text

Piantadosi, CA, and Suliman, HB. "Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes." Biochim Biophys Acta 1820, no. 4 (April 2012): 532-541. (Review)

PMID
22265687
Full Text

Badea, CT, Guo, X, Clark, D, Johnston, SM, Marshall, C, and Piantadosi, C. "Lung imaging in rodents using dual energy micro-CT." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8317 (2012).

PMID
24027623
Full Text

Cherry, AD, Bartz, RR, Fu, P, Piantadosi, CA, and Suliman, HB. "PGC-1 alpha and the Mitochondrial Antioxidant Response during Sepsis." November 1, 2011.

Full Text

Suliman, HB, and Piantadosi, CA. "Heme Oxygenase 1 Promotes Murine Stem Cell Differentiation into Beating Cardiomyocytes." November 1, 2011.

Full Text

Piantadosi, CA, Withers, CM, Bartz, RR, MacGarvey, NC, Fu, P, Sweeney, TE, Welty-Wolf, KE, and Suliman, HB. "Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression." The Journal of Biological Chemistry 286, no. 18 (May 2011): 16374-16385.

PMID
21454555
Full Text

Rajagopal, S, Kovacs, J, Badea, C, Johnson, GA, Rockman, HA, Piantadosi, CA, and Lefkowitz, RJ. "BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 57, no. 14 (April 5, 2011): E2046-E2046.

Full Text

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