Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Piantadosi, CA, Withers, CM, Bartz, RR, MacGarvey, NC, Sweeney, TE, Welty-Wolf, KE, and Suliman, HB. "Redox Activation of Mitochondrial Biogenesis by Heme Oxygenase-1 Exerts Counter-regulatory Control over NF-kB-dependent Cytokine Production." April 2011.

Scholars@Duke

Sheng, H, Reynolds, JD, Auten, RL, Demchenko, IT, Piantadosi, CA, Stamler, JS, and Warner, DS. "Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage." Stroke 42, no. 2 (February 2011): 471-476.

PMID
21193749
Full Text

Bartz, RR, Suliman, HB, Fu, P, Welty-Wolf, K, Carraway, MS, MacGarvey, NC, Withers, CM, Sweeney, TE, and Piantadosi, CA. "Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice." Am J Respir Crit Care Med 183, no. 2 (January 15, 2011): 226-233.

PMID
20732986
Full Text

Sweeney, TE, Suliman, HB, Hollingsworth, JW, Welty-Wolf, KE, and Piantadosi, CA. "A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis." Plos One 6, no. 9 (January 2011): e25249-null.

PMID
21966468
Full Text

Demchenko, IT, Zhilyaev, SY, Moskvin, AN, Piantadosi, CA, and Allen, BW. "Autonomic activation links CNS oxygen toxicity to acute cardiogenic pulmonary injury." American Journal of Physiology. Lung Cellular and Molecular Physiology 300, no. 1 (January 2011): L102-L111.

PMID
20971806
Full Text

Li, Z, Potts, EN, Piantadosi, CA, Foster, WM, and Hollingsworth, JW. "Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide." J Immunol 185, no. 11 (December 1, 2010): 6891-6898.

PMID
21037098
Full Text

Carré, JE, Orban, J-C, Re, L, Felsmann, K, Iffert, W, Bauer, M, Suliman, HB, Piantadosi, CA, Mayhew, TM, Breen, P, Stotz, M, and Singer, M. "Survival in critical illness is associated with early activation of mitochondrial biogenesis." American Journal of Respiratory and Critical Care Medicine 182, no. 6 (September 2010): 745-751.

PMID
20538956
Full Text

Bennett, M, Mitchell, S, Neuman, T, Piantadosi, CA, Feldmeier, J, Hampson, NB, Smart, D, Wilkinson, D, and Bryson, P. "Hyperbaric oxygen therapy and neurological disease." Undersea Hyperb Med 37, no. 5 (September 2010): 371-373. (Letter)

PMID
20929186
Scholars@Duke

Suliman, HB, Sweeney, TE, Withers, CM, and Piantadosi, CA. "Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis." Journal of Cell Science 123, no. Pt 15 (August 2010): 2565-2575.

PMID
20587593
Full Text

Sweeney, TE, Suliman, HB, Hollingsworth, JW, and Piantadosi, CA. "Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. (Published online)" PLoS One 5, no. 7 (July 15, 2010): e11606-.

PMID
20657826
Full Text

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