Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Suliman, HB, Babiker, A, Withers, CM, Sweeney, TE, Carraway, MS, Tatro, LG, Bartz, RR, Welty-Wolf, KE, and Piantadosi, CA. "Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice." Free Radic Biol Med 48, no. 5 (March 1, 2010): 736-746.

PMID
20043987
Full Text

Piantadosi, CA, Tatro, LG, and Suliman, HB. "Deconstructing Mitochondria: Co-localization of HO-1 and LC3II Mitophagy Protein in Liver Mitochondria during Oxidative Stress and Sepsis." 2010.

Full Text

Turi, JL, Mamo, LB, Ghio, AJ, and Piantadosi, CA. "Iron Induces Heme-oxygenase-1 Expression And Activity In Endothelial Cells." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 181 (2010).

Scholars@Duke

MacGarvey, NC, Suliman, HB, and Piantadosi, CA. "THE HO/CO SYSTEM PROMOTES HEPATIC MITOCHONDRIAL BIOGENESIS DURING STAPHYLOCOCCUS AUREUS SEPSIS." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 181 (2010).

Scholars@Duke

Bartz, RR, and Piantadosi, CA. "Clinical review: oxygen as a signaling molecule." Crit Care 14, no. 5 (2010): 234-. (Review)

PMID
21062512
Full Text

Bennett, M, Mitchell, S, Neuman, T, Piantadosi, CA, Feldmeier, J, Hampson, NB, Smart, D, Wilkinson, D, and Bryson, P. "Hyperbaric oxygen therapy and neurological disease." Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 37, no. 5 (2010): 371-373.

Scholars@Duke

Freiberger, JJ, Yoo, DS, de Lisle Dear, G, McGraw, TA, Blakey, GH, Padilla Burgos, R, Kraft, K, Nelson, JW, Moon, RE, and Piantadosi, CA. "Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis." Int J Radiat Oncol Biol Phys 75, no. 3 (November 1, 2009): 717-724.

PMID
19328634
Full Text

Lin, M, Marshall, CT, Qi, Y, Johnston, SM, Badea, CT, Piantadosi, CA, and Johnson, GA. "Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography." Med Phys 36, no. 11 (November 2009): 5347-5358.

PMID
19994543
Full Text

Kliment, CR, Suliman, HB, Tobolewski, JM, Reynolds, CM, Day, BJ, Zhu, X, McTiernan, CF, McGaffin, KR, Piantadosi, CA, and Oury, TD. "Extracellular superoxide dismutase regulates cardiac function and fibrosis." J Mol Cell Cardiol 47, no. 5 (November 2009): 730-742.

PMID
19695260
Full Text

Allen, BW, Stamler, JS, and Piantadosi, CA. "Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation." Trends Mol Med 15, no. 10 (October 2009): 452-460. (Review)

PMID
19781996
Full Text

Pages