Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Professor of Pathology
Assistant Professor in Anesthesiology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Piantadosi, CA. "Carbon monoxide, reactive oxygen signaling, and oxidative stress." Free Radic Biol Med 45, no. 5 (September 1, 2008): 562-569. (Review)

PMID
18549826
Full Text

Piantadosi, CA. "Carbon monoxide, reactive oxygen signaling, and oxidative stress." FREE RADICAL BIOLOGY AND MEDICINE 45, no. 5 (September 1, 2008): 562-569.

Full Text

Ghio, AJ, Stonehuerner, JG, Dailey, LA, Richards, JH, Madden, MD, Deng, Z, Nguyen, N-B, Callaghan, KD, Yang, F, and Piantadosi, CA. "Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function." Am J Respir Cell Mol Biol 38, no. 6 (June 2008): 715-723.

PMID
18203974
Full Text

Demchenko, IT, Atochin, DN, Gutsaeva, DR, Godfrey, RR, Huang, PL, Piantadosi, CA, and Allen, BW. "Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects." Am J Physiol Lung Cell Mol Physiol 294, no. 5 (May 2008): L984-L990.

PMID
18326824
Full Text

Harrah, JD, O'Boyle, PS, and Piantadosi, CA. "Underutilization of echocardiography for patent foramen ovale in divers with serious decompression sickness." Undersea Hyperb Med 35, no. 3 (May 2008): 207-211.

PMID
18619116
Scholars@Duke

Piantadosi, CA, and Suliman, HB. "Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells." J Biol Chem 283, no. 16 (April 18, 2008): 10967-10977.

PMID
18252725
Full Text

Gutsaeva, DR, Carraway, MS, Suliman, HB, Demchenko, IT, Shitara, H, Yonekawa, H, and Piantadosi, CA. "Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism." J Neurosci 28, no. 9 (February 27, 2008): 2015-2024.

PMID
18305236
Full Text

Carraway, MS, Suliman, HB, Kliment, C, Welty-Wolf, KE, Oury, TD, and Piantadosi, CA. "Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis." Antioxid Redox Signal 10, no. 2 (February 2008): 269-275.

PMID
17999632
Full Text

Ghio, AJ, Stonehuerner, JG, Richards, JH, Crissman, KM, Roggli, VL, Piantadosi, CA, and Carraway, MS. "Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. (Published online)" Respir Res 9 (January 23, 2008): 10-.

PMID
18215276
Full Text

Forkner, IF, Piantadosi, CA, Charles, HC, Scafetta, N, and Moon, RE. "Hyperoxia-induced decrease in organ blood flow [10]." Anesthesiology 108, no. 1 (2008): 169-170.

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