Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Rhodes, MA, Carraway, MS, Piantadosi, CA, Reynolds, CM, Cherry, AD, Wester, TE, Natoli, MJ, Massey, EW, Moon, RE, and Suliman, HB. "Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans." Am J Physiol Heart Circ Physiol 297, no. 1 (July 2009): H392-H399.

PMID
19465554
Full Text

Atochin, DN, Gutsaeva, DR, Li, Q, Demchenko, IT, Piantadosi, CA, and Huang, PL. "Hypoxic Preconditioning Stimulates Mitochondrial Biogenesis and Promotes Brain Ischemic Tolerance by Akt Pathway Activation." STROKE 40, no. 4 (April 2009): E139-E139.

Scholars@Duke

Demchenko, IT, Ruehle, A, Allen, BW, Vann, RD, and Piantadosi, CA. "Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen." J Appl Physiol (1985) 106, no. 4 (April 2009): 1234-1242.

PMID
19179645
Full Text

Reynolds, CM, Suliman, HB, Hollingsworth, JW, Welty-Wolf, KE, Carraway, MS, and Piantadosi, CA. "Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia." Free Radic Biol Med 46, no. 5 (March 1, 2009): 564-572.

PMID
19073249
Full Text

Allen, BW, Demchenko, IT, and Piantadosi, CA. "Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity." J Appl Physiol (1985) 106, no. 2 (February 2009): 662-667. (Review)

PMID
18845774
Full Text

Piantadosi, CA, Carraway, MS, Babiker, A, and Suliman, HB. "Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1." Circ Res 103, no. 11 (November 21, 2008): 1232-1240.

PMID
18845810
Full Text

Turi, JL, Piantadosi, CA, Stonehuerner, JD, and Ghio, AJ. "Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport." Biometals 21, no. 5 (October 2008): 571-580.

PMID
18483768
Full Text

Stamler, JS, Singel, DJ, and Piantadosi, CA. "SNO-hemoglobin and hypoxic vasodilation." Nat Med 14, no. 10 (October 2008): 1008-1009. (Letter)

PMID
18841126
Full Text

Piantadosi, CA. "Carbon monoxide, reactive oxygen signaling, and oxidative stress." Free Radic Biol Med 45, no. 5 (September 1, 2008): 562-569. (Review)

PMID
18549826
Full Text

Piantadosi, CA. "Carbon monoxide, reactive oxygen signaling, and oxidative stress." FREE RADICAL BIOLOGY AND MEDICINE 45, no. 5 (September 1, 2008): 562-569.

Full Text

Pages