Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Mudrick, D, Kaltenbach, LA, Shah, B, Lytle, B, Masoudi, FA, Mark, DB, Federspiel, JJ, Cowper, PA, Green, C, and Douglas, PS. "Downstream testing and subsequent procedures after coronary computed tomographic angiography following coronary stenting in patients ≥65 years of age." American Journal of Cardiology 110, no. 6 (2012): 776-783.

PMID
22651883
Full Text

Lamas, GA, Goertz, C, Boineau, R, Mark, DB, Rozema, T, Nahin, RL, Drisko, JA, and Lee, KL. "Design of the Trial to Assess Chelation Therapy (TACT)." American Heart Journal 163, no. 1 (2012): 7-12.

PMID
22172430
Full Text

Reynolds, HR, Forman, SA, Tamis-Holland, JE, Steg, PG, Mark, DB, Pearte, CA, Carvalho, AC, Sopko, G, Liu, L, Lamas, GA, Kruk, M, Loboz-Grudzien, K, Ruzyllo, W, and Hochman, JS. "Relationship of female sex to outcomes after myocardial infarction with persistent total occlusion of the infarct artery: Analysis of the Occluded Artery Trial (OAT)." American Heart Journal 163, no. 3 (2012): 462-469.

PMID
22424018
Full Text

Dunbar, SB, Dougherty, CM, Sears, SF, Carroll, DL, Goldstein, NE, Mark, DB, McDaniel, G, Pressler, SJ, Schron, E, Wang, P, and Zeigler, VL. "Educational and psychological interventions to improve outcomes for recipients of implantable cardioverter defibrillators and their families: A scientific statement from the american heart association." Circulation 126, no. 17 (2012): 2146-2172.

PMID
23008437
Full Text

Hochman, JS, Reynolds, HR, Dzavík, V, Buller, CE, Ruzyllo, W, Sadowski, ZP, Maggioni, AP, Carvalho, AC, Rankin, JM, White, HD, Goldberg, S, Forman, SA, Mark, DB, Lamas, GA, and Occluded Artery Trial Investigators, . "Long-term effects of percutaneous coronary intervention of the totally occluded infarct-related artery in the subacute phase after myocardial infarction." Circulation 124, no. 21 (November 22, 2011): 2320-2328.

PMID
22025606
Full Text

Chin, CT, Wang, TY, Anstrom, KJ, Zhu, B, Maa, J-F, Messenger, JC, Ryan, KA, Davidson-Ray, L, Zettler, M, Effron, MB, Mark, DB, and Peterson, ED. "Treatment with adenosine diphosphate receptor inhibitors-longitudinal assessment of treatment patterns and events after acute coronary syndrome (TRANSLATE-ACS) study design: expanding the paradigm of longitudinal observational research." Am Heart J 162, no. 5 (November 2011): 844-851.

PMID
22093200
Full Text

Mark, DB, Patel, MR, and Anstrom, KJ. "Trade-offs and toss-ups: making revascularization decisions in carotid artery disease." J Am Coll Cardiol 58, no. 15 (October 4, 2011): 1566-1568.

PMID
21958883
Full Text

Swaminathan, M, Nicoara, A, Phillips-Bute, BG, Aeschlimann, N, Milano, CA, Mackensen, GB, Podgoreanu, MV, Velazquez, EJ, Stafford-Smith, M, Mathew, JP, and Cardiothoracic Anesthesia Research Endeavors (CARE) Group, . "Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery." Ann Thorac Surg 91, no. 6 (June 2011): 1844-1850.

PMID
21492828
Full Text

Barefoot, JC, Brummett, BH, Williams, RB, Siegler, IC, Helms, MJ, Boyle, SH, Clapp-Channing, NE, and Mark, DB. "Recovery expectations and long-term prognosis of patients with coronary heart disease." Arch Intern Med 171, no. 10 (May 23, 2011): 929-935.

PMID
21357800
Full Text

Piccini, JP, Al-Khatib, SM, Hellkamp, AS, Anstrom, KJ, Poole, JE, Mark, DB, Lee, KL, and Bardy, GH. "Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)." Heart Rhythm 8, no. 3 (March 2011): 393-400.

PMID
21109025
Full Text

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