Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Lamas, G. A., C. Goertz, R. Boineau, D. B. Mark, T. Rozema, R. L. Nahin, L. Lindblad, et al. “Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial..” Jama : The Journal of the American Medical Association 309, no. 12 (2013): 1241–50. https://doi.org/10.1001/jama.2013.2107.

Full Text

Mark, Daniel B., Kevin J. Anstrom, Robin Boineau, Christine Goertz, Theodore C. Rozema, J David Knight, Nancy E. Clapp-Channing, et al. “Quality of Life Outcomes in the Trial to Assess Chelation Therapy (TACT).” In Circulation, 126:2779–80. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Lamas, Gervasio A., Robin Boineau, Christine Goertz, Daniel B. Mark, Theodore C. Rozema, Richard L. Nahin, Yves Rosenberg, Mario Stylianou, Jeanne Drisko, and Kerry L. Lee. “Results of the Trial to Assess Chelation Therapy.” In Circulation, 126:2778–79. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Dunbar, Sandra B., Cynthia M. Dougherty, Samuel F. Sears, Diane L. Carroll, Nathan E. Goldstein, Daniel B. Mark, George McDaniel, et al. “Educational and psychological interventions to improve outcomes for recipients of implantable cardioverter defibrillators and their families: a scientific statement from the American Heart Association..” Circulation 126, no. 17 (October 23, 2012): 2146–72. https://doi.org/10.1161/CIR.0b013e31825d59fd.

PMID
23008437
Full Text

Mudrick, Daniel, Lisa A. Kaltenbach, Bimal Shah, Barbara Lytle, Frederick A. Masoudi, Daniel B. Mark, Jerome J. Federspiel, Patricia A. Cowper, Cynthia Green, and Pamela S. Douglas. “Downstream testing and subsequent procedures after coronary computed tomographic angiography following coronary stenting in patients ≥65 years of age..” Am J Cardiol 110, no. 6 (September 15, 2012): 776–83. https://doi.org/10.1016/j.amjcard.2012.05.004.

PMID
22651883
Full Text

Reynolds, Harmony R., Sandra A. Forman, Jacqueline E. Tamis-Holland, Philippe Gabriel Steg, Daniel B. Mark, Camille A. Pearte, Antonio C. Carvalho, et al. “Relationship of female sex to outcomes after myocardial infarction with persistent total occlusion of the infarct artery: analysis of the Occluded Artery Trial (OAT)..” Am Heart J 163, no. 3 (March 2012): 462–69. https://doi.org/10.1016/j.ahj.2012.01.005.

PMID
22424018
Full Text

Lamas, Gervasio A., Christine Goertz, Robin Boineau, Daniel B. Mark, Theodore Rozema, Richard L. Nahin, Jeanne A. Drisko, and Kerry L. Lee. “Design of the Trial to Assess Chelation Therapy (TACT)..” Am Heart J 163, no. 1 (January 2012): 7–12. https://doi.org/10.1016/j.ahj.2011.10.002.

PMID
22172430
Full Text

Hochman, Judith S., Harmony R. Reynolds, Vladimír Dzavík, Christopher E. Buller, Witold Ruzyllo, Zygmunt P. Sadowski, Aldo P. Maggioni, et al. “Long-term effects of percutaneous coronary intervention of the totally occluded infarct-related artery in the subacute phase after myocardial infarction..” Circulation 124, no. 21 (November 22, 2011): 2320–28. https://doi.org/10.1161/CIRCULATIONAHA.111.041749.

PMID
22025606
Full Text

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