Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Piccini, JP, Al-Khatib, SM, Hellkamp, AS, Anstrom, KJ, Poole, JE, Mark, DB, Lee, KL, and Bardy, GH. "Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)." Heart Rhythm 8, no. 3 (March 2011): 393-400.

PMID
21109025
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Martin, SS, Karra, R, and Mark, DB. "Pheochromocytoma presenting as fever of unknown origin." The American Journal of Medicine 124, no. 2 (February 2011): e5-e6. (Letter)

PMID
21092927
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Strauss, DG, Poole, JE, Wagner, GS, Selvester, RH, Miller, JM, Anderson, J, Johnson, G, McNulty, SE, Mark, DB, Lee, KL, Bardy, GH, and Wu, KC. "An ECG index of myocardial scar enhances prediction of defibrillator shocks: an analysis of the Sudden Cardiac Death in Heart Failure Trial." Heart Rhythm 8, no. 1 (January 2011): 38-45.

PMID
20884379
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Devlin, G, Reynolds, HR, Mark, DB, Rankin, JM, Carvalho, AC, Vozzi, C, Sopko, G, Caramori, P, Džavík, V, Ragosta, M, Forman, SA, Lamas, GA, and Hochman, JS. "Loss of short-term symptomatic benefit in patients with an occluded infarct artery is unrelated to non-protocol revascularization: results from the Occluded Artery Trial (OAT)." American Heart Journal 161, no. 1 (January 2011): 84-90.

PMID
21167338
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Al-Khatib, SM, Hellkamp, A, Curtis, J, Mark, D, Peterson, E, Sanders, GD, Heidenreich, PA, Hernandez, AF, Curtis, LH, and Hammill, S. "Non-evidence-based ICD implantations in the United States." Jama 305, no. 1 (January 2011): 43-49.

PMID
21205965
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Al-Khatib, SM, Mark, D, and Hammill, S. "In reply." JAMA - Journal of the American Medical Association 305, no. 15 (2011): 1539-1540.

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Taylor, AJ, Cerqueira, M, Hodgson, JM, Mark, D, Min, J, O'Gara, P, Rubin, GD, American College of Cardiology Foundation Appropriate Use Criteria Task Force, , Society of Cardiovascular Computed Tomography, , American College of Radiology, , American Heart Association, , American Society of Echocardiography, , American Society of Nuclear Cardiology, , North American Society for Cardiovascular Imaging, , Society for Cardiovascular Angiography and Interventions, , and Society for Cardiovascular Magnetic Resonance, . "ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance." Journal of Cardiovascular Computed Tomography 4, no. 6 (November 23, 2010): 407.e1-407.33.

PMID
21232696
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Taylor, AJ, Cerqueira, M, Hodgson, JM, Mark, D, Min, J, O'Gara, P, Rubin, GD, American College of Cardiology Foundation Appropriate Use Criteria Task Force, , Society of Cardiovascular Computed Tomography, , American College of Radiology, , American Heart Association, , American Society of Echocardiography, , American Society of Nuclear Cardiology, , North American Society for Cardiovascular Imaging, , Society for Cardiovascular Angiography and Interventions, , and Society for Cardiovascular Magnetic Resonance, . "ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance." Circulation 122, no. 21 (November 2010): e525-e555.

PMID
20975004
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Taylor, AJ, Cerqueira, M, Hodgson, JM, Mark, D, Min, J, O'Gara, P, Rubin, GD, American College of Cardiology Foundation Appropriate Use Criteria Task Force, , Society of Cardiovascular Computed Tomography, , American College of Radiology, , American Heart Association, , American Society of Echocardiography, , American Society of Nuclear Cardiology, , North American Society for Cardiovascular Imaging, , Society for Cardiovascular Angiography and Interventions, , Society for Cardiovascular Magnetic Resonance, , Kramer, CM, Berman, D, Brown, A, Chaudhry, FA, Cury, RC, Desai, MY, Einstein, AJ, Gomes, AS, Harrington, R, Hoffmann, U, Khare, R, Lesser, J, McGann, C, Rosenberg, A, Schwartz, R, Shelton, M, Smetana, GW, and Smith, SC. "ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography. A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance." Journal of the American College of Cardiology 56, no. 22 (November 2010): 1864-1894.

PMID
21087721
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Packer, DL, Frantz, RP, Prutkin, JM, Poole, JE, Hellkamp, AS, Wood, F, McNulty, SE, Rogers, JG, Mark, DB, Lee, KL, Mitchell, LB, Bernstein, RC, Boehmer, JP, Carlson, MD, Anderson, J, Bardy, GH, Johnson, GW, and Walsh, MN. "Response to Letter Regarding Article, "Impact of Implantable Cardioverter-Defibrillator, Amiodarone, and Placebo on the Mode of Death in Stable Patients With Heart Failure: Analysis From the Sudden Cardiac Death in Heart Failure Trial"." Circulation 122, no. 15 (October 12, 2010): e487-e487.

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