Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Mark, Daniel B., Kevin J. Anstrom, Shubin Sheng, Jonathan P. Piccini, Khaula N. Baloch, Kristi H. Monahan, Melanie R. Daniels, et al. “Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.” Jama 321, no. 13 (April 2, 2019): 1275–85. https://doi.org/10.1001/jama.2019.0692.

PMID
30874716
Full Text

Packer, Douglas L., Daniel B. Mark, Richard A. Robb, Kristi H. Monahan, Tristram D. Bahnson, Jeanne E. Poole, Peter A. Noseworthy, et al. “Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.” Jama 321, no. 13 (April 2, 2019): 1261–74. https://doi.org/10.1001/jama.2019.0693.

PMID
30874766
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Sharma, Abhinav, Adrian Coles, Nishant K. Sekaran, Neha J. Pagidipati, Michael T. Lu, Daniel B. Mark, Kerry L. Lee, Hussein R. Al-Khalidi, Udo Hoffmann, and Pamela S. Douglas. “Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.” J Am Coll Cardiol 73, no. 8 (March 5, 2019): 893–902. https://doi.org/10.1016/j.jacc.2018.11.056.

PMID
30819356
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Hochman, Judith S., Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, Karen P. Alexander, Roxy Senior, William E. Boden, et al. “Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial.” Jama Cardiol 4, no. 3 (March 1, 2019): 273–86. https://doi.org/10.1001/jamacardio.2019.0014.

PMID
30810700
Full Text

Buckland, D. M., M. M. Cummings, D. B. Mark, A. G. Banerjee, K. Snyder, and M. A. Starks. “Design Considerations for UAV-Delivered Opioid Overdose Interventions.” In Ieee Aerospace Conference Proceedings, Vol. 2019-March, 2019. https://doi.org/10.1109/AERO.2019.8741937.

Full Text

Pagidipati, Neha J., Adrian Coles, Kshipra Hemal, Kerry L. Lee, Rowena J. Dolor, Patricia A. Pellikka, Daniel B. Mark, et al. “Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.” Am Heart J 208 (February 2019): 28–36. https://doi.org/10.1016/j.ahj.2018.11.002.

PMID
30529930
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Daubert, Melissa A., Kirkwood Adams, Eric Yow, Huiman X. Barnhart, Pamela S. Douglas, Susan Rimmer, Casey Norris, et al. “NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF.” Jacc Heart Fail 7, no. 2 (February 2019): 158–68. https://doi.org/10.1016/j.jchf.2018.10.014.

PMID
30611722
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Jang, James J., Manjushri Bhapkar, Adrian Coles, Sreekanth Vemulapalli, Christopher B. Fordyce, Kerry L. Lee, James E. Udelson, et al. “Predictive Model for High-Risk Coronary Artery Disease.” Circ Cardiovasc Imaging 12, no. 2 (February 2019): e007940. https://doi.org/10.1161/CIRCIMAGING.118.007940.

PMID
30712364
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Mark, Daniel B., Patricia A. Cowper, Kevin J. Anstrom, Shubin Sheng, Melanie R. Daniels, J David Knight, Khaula N. Baloch, et al. “Economic and Quality-of-Life Outcomes of Natriuretic Peptide-Guided Therapy for Heart Failure.” J Am Coll Cardiol 72, no. 21 (November 27, 2018): 2551–62. https://doi.org/10.1016/j.jacc.2018.08.2184.

PMID
30466512
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Bangalore, Sripal, David J. Maron, Jerome L. Fleg, Sean M. O’Brien, Charles A. Herzog, Gregg W. Stone, Daniel B. Mark, et al. “International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design.” Am Heart J 205 (November 2018): 42–52. https://doi.org/10.1016/j.ahj.2018.07.023.

PMID
30172098
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