Geriatrics

Daniel Christopher Parker, MD

Assistant Professor of Medicine
Assistant Professor in Neurology
Senior Fellow of the Center for the Study of Aging and Human Development
Campus mail Rm 1510 Blue Zone Duke South, Box 3003, Durham, NC 27705
Phone (919) 660-7692
Email address daniel.parker@duke.edu

Biological aging is the greatest risk factor for most chronic diseases, including frailty and dementia. The geroscience hypothesis posits that interventions that target aspects of biological aging may delay or prevent many of these diseases simultaneously. My research centers on understanding the mechanisms of interventions that affect biological aging, like exercise training and caloric restriction and using that understanding to develop therapies that maintain cognitive and physical function in older adults.

Education and Training

  • Post-Doctoral Research Fellowship, Duke Center For The Study Of Aging And Human Development, Duke University School of Medicine, 2017 - 2019
  • Internal Medicine Residency, Eastern Virginia Medical School, 2013 - 2016
  • Advanced Fellowship in Geriatric Medicine, Medicine, ,, 0018
  • M.D., Eastern Virginia Medical School, 2013

Grants

Publications

Morey, Miriam C., Cathy C. Lee, Steven Castle, Willy M. Valencia, Leslie Katzel, Jamie Giffuni, Teresa Kopp, et al. “Should Structured Exercise Be Promoted As a Model of Care? Dissemination of the Department of Veterans Affairs Gerofit Program.” J Am Geriatr Soc 66, no. 5 (May 2018): 1009–16. https://doi.org/10.1111/jgs.15276.

PMID
29430642
Full Text

Parker, D. C., K. Hall, M. Morey, and R. Sloane. “Sedentary Behavior is Associated with Elevations in Pro-Inflammatory Biomarkers.” In Journal of the American Geriatrics Society, 65:S119–S119. WILEY, 2017.

Scholars@Duke

Parker, D. C., C. Hecht-Leavett, T. Cunningham, and H. Okhravi. “Visual Versus Automated Rating of Hippocampal Atrophy.” In Journal of the American Geriatrics Society, 65:S145–46. WILEY, 2017.

Scholars@Duke

Parker, Daniel C., Michelle M. Mielke, Qilu Yu, Paul B. Rosenberg, Alka Jain, Constantine G. Lyketsos, Neal S. Fedarko, and Esther S. Oh. “Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease.” Int J Geriatr Psychiatry 28, no. 2 (February 2013): 149–54. https://doi.org/10.1002/gps.3802.

PMID
22539447
Full Text

Archin, N. M., A. L. Liberty, A. D. Kashuba, S. K. Choudhary, J. D. Kuruc, A. M. Crooks, D. C. Parker, et al. “Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy.” Nature 487, no. 7408 (July 25, 2012): 482–85. https://doi.org/10.1038/nature11286.

PMID
22837004
Full Text

Anderson, Jeffrey A., Nancie M. Archin, William Ince, Daniel Parker, Ann Wiegand, John M. Coffin, Joann Kuruc, Joseph Eron, Ronald Swanstrom, and David M. Margolis. “Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells.” J Virol 85, no. 10 (May 2011): 5220–23. https://doi.org/10.1128/JVI.00284-11.

PMID
21367910
Full Text

Archin, Nancie M., Manzoor Cheema, Daniel Parker, Ann Wiegand, Ronald J. Bosch, John M. Coffin, Joseph Eron, Myron Cohen, and David M. Margolis. “Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection.” Plos One 5, no. 2 (February 23, 2010): e9390. https://doi.org/10.1371/journal.pone.0009390.

PMID
20186346
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Levesque, Marc C., M Anthony Moody, Kwan-Ki Hwang, Dawn J. Marshall, John F. Whitesides, Joshua D. Amos, Thaddeus C. Gurley, et al. “Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.” Plos Med 6, no. 7 (July 7, 2009): e1000107. https://doi.org/10.1371/journal.pmed.1000107.

PMID
19582166
Full Text

Archin, Nancie M., Amy Espeseth, Daniel Parker, Manzoor Cheema, Daria Hazuda, and David M. Margolis. “Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.” Aids Res Hum Retroviruses 25, no. 2 (February 2009): 207–12. https://doi.org/10.1089/aid.2008.0191.

PMID
19239360
Full Text

Parker, Daniel, and Mitchell Heflin. “Biology of Aging.” In Principles and Practice of Geriatric Surgery, edited by Ronnie A. Rosenthal, Michael E. Zenilman, and Mark R. Katlic, 1–14. Springer Reference, n.d. https://doi.org/10.1007/978-3-319-20317-1.

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