Daniel John Sexton, MD

Professor of Medicine
Campus mail Duke Box 102359, Durham, NC 27710
Phone (919) 684-4596
Email address sexto002@mc.duke.edu

During the past 8 years my research interests have changed from a focus on tick-borne disease and endocarditis to a primary focus on healthcare-associated infections (HAIs). Specifically, I have been interested in HAIs in community hospitals. Using prospective data collected as part of our surveillance activities in the Duke Infection Control Outreach Network (DICON), I and my colleagues have focused on these specific areas of research:

• The accuracy and reliability of surveillance definitions used to document and trend rates of HAIs
• Outcomes of HAIs (both financial and clinical) with particular emphasis on bloodstream and surgical site infections
• Trends in HAIs due to pathogens resistant to common antimicrobial agents
• Temporal and geographic variations in the occurrence of pathogens such as methicillin-resistant S. aureus, E coli and Klebsiella pneumonia
• The prevention and control of HAIs with particular emphasis on the potential role of the environment in the transmission of HAIs

As the principal investigator on one of the 5 national epicenter grants funded by the Centers for Disease control I, along with my co-investigators from the Duke and University of North Carolina Division of Infectious Disease, are involved in a 5-year prospective study of the potential benefit of enhanced cleaning methods (such as the use of ultraviolet light emitters) in the prevention of HAIs. This study involves 9 hospitals in North Carolina and Virginia and will include a trial of 4 different cleaning methods utilized sequentially but randomly in these study hospitals over a 28-month time period. Additionally the Duke Epicenter is also undertaking prospective trials investigating the utility and reliability of new (streamlined) definitions of ventilator-associated pneumonia.

Key words that characterize my work: surgical site infections and nosocomial infections.

Education and Training

  • Internship, General Medicine, Icahn School of Medicine at Mount Sinai, 1971 - 1972
  • Residency, General Internal Medicine, University of Missouri - Columbia School of Medicine, 1197
  • Fellowship, Infectious Diseases, Duke University School of Medicine, 1197
  • M.D., Northwestern University, 1971

Publications

Knelson, LP, Williams, DA, Gergen, MF, Rutala, WA, Weber, DJ, Sexton, DJ, Anderson, DJ, and Centers for Disease Control and Prevention Epicenters Program, . "A comparison of environmental contamination by patients infected or colonized with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a multicenter study." Infection control and hospital epidemiology 35, no. 7 (July 2014): 872-875.

PMID
24915217
Full Text

Alagna, L, Park, LP, Nicholson, BP, Keiger, AJ, Strahilevitz, J, Morris, A, Wray, D, Gordon, D, Delahaye, F, Edathodu, J, Miró, JM, Fernández-Hidalgo, N, Nacinovich, FM, Shahid, R, Woods, CW, Joyce, MJ, Sexton, DJ, and Chu, VH. "Repeat endocarditis: analysis of risk factors based on the International Collaboration on Endocarditis - Prospective Cohort Study." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 20, no. 6 (June 2014): 566-575.

PMID
24102907
Full Text

Dicks, KV, Lewis, SS, Durkin, MJ, Baker, AW, Moehring, RW, Chen, LF, Sexton, DJ, and Anderson, DJ. "Surveying the surveillance: surgical site infections excluded by the January 2013 updated surveillance definitions." Infection control and hospital epidemiology 35, no. 5 (May 2014): 570-573.

PMID
24709727
Full Text

Moehring, RW, Lewis, SS, Isaacs, PJ, Schell, WA, Thomann, WR, Althaus, MM, Hazen, KC, Dicks, KV, Lipuma, JJ, Chen, LF, and Sexton, DJ. "Outbreak of bacteremia due to Burkholderia contaminans linked to intravenous fentanyl from an institutional compounding pharmacy." Jama Internal Medicine 174, no. 4 (April 2014): 606-612.

PMID
24493147
Full Text

Anderson, DJ, and Sexton, DJ. "Surgical antimicrobial prophylaxis: is the glass half empty or more than 99% full?." Infection control and hospital epidemiology 35, no. 3 (March 2014): 240-242.

PMID
24521587
Full Text

Alagna, L, Park, LP, Nicholson, BP, Keiger, AJ, Strahilevitz, J, Morris, A, Wray, D, Gordon, D, Delahaye, F, Edathodu, J, Miró, JM, Fernández-Hidalgo, N, Nacinovich, FM, Shahid, R, Woods, CW, Joyce, MJ, Sexton, DJ, and Chu, VH. "Repeat endocarditis: Analysis of risk factors based on the International collaboration on endocarditis - Prospective cohort study." Clinical Microbiology and Infection 20, no. 6 (January 1, 2014): 566-575.

Full Text

Chen, LF, Freeman, JT, Nicholson, B, Keiger, A, Lancaster, S, Joyce, M, Woods, CW, Cook, E, Adcock, L, Louis, S, Cromer, AL, Sexton, DJ, and Anderson, DJ. "Widespread dissemination of CTX-M-15 genotype extended-spectrum-β-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States." Antimicrobial Agents and Chemotherapy 58, no. 2 (January 2014): 1200-1202.

PMID
24247126
Full Text

Anderson, DJ, Moehring, RW, Sloane, R, Schmader, KE, Weber, DJ, Fowler, VG, Smathers, E, and Sexton, DJ. "Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study." Plos One 9, no. 3 (January 2014): e91713-null.

PMID
24643200
Full Text

Lewis, SS, Moehring, RW, Chen, LF, Sexton, DJ, and Anderson, DJ. "Assessing the relative burden of hospital-acquired infections in a network of community hospitals." Infection Control and Hospital Epidemiology 34, no. 11 (November 2013): 1229-1230.

PMID
24113613
Full Text

Catania, J, Martin, SS, Corey, GR, and Sexton, DS. "Diagnostic dilemma in a returning traveler with fever." Diagnostic microbiology and infectious disease 77, no. 1 (September 2013): 85-86.

PMID
23871414
Full Text

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