Daniel John Sexton, MD

Professor of Medicine
Campus mail Duke Box 102359, Durham, NC 27710
Phone (919) 684-4596
Email address sexto002@mc.duke.edu

During the past 8 years my research interests have changed from a focus on tick-borne disease and endocarditis to a primary focus on healthcare-associated infections (HAIs). Specifically, I have been interested in HAIs in community hospitals. Using prospective data collected as part of our surveillance activities in the Duke Infection Control Outreach Network (DICON), I and my colleagues have focused on these specific areas of research:

• The accuracy and reliability of surveillance definitions used to document and trend rates of HAIs
• Outcomes of HAIs (both financial and clinical) with particular emphasis on bloodstream and surgical site infections
• Trends in HAIs due to pathogens resistant to common antimicrobial agents
• Temporal and geographic variations in the occurrence of pathogens such as methicillin-resistant S. aureus, E coli and Klebsiella pneumonia
• The prevention and control of HAIs with particular emphasis on the potential role of the environment in the transmission of HAIs

As the principal investigator on one of the 5 national epicenter grants funded by the Centers for Disease control I, along with my co-investigators from the Duke and University of North Carolina Division of Infectious Disease, are involved in a 5-year prospective study of the potential benefit of enhanced cleaning methods (such as the use of ultraviolet light emitters) in the prevention of HAIs. This study involves 9 hospitals in North Carolina and Virginia and will include a trial of 4 different cleaning methods utilized sequentially but randomly in these study hospitals over a 28-month time period. Additionally the Duke Epicenter is also undertaking prospective trials investigating the utility and reliability of new (streamlined) definitions of ventilator-associated pneumonia.

Key words that characterize my work: surgical site infections and nosocomial infections.

Education and Training

  • Internship, General Medicine, Icahn School of Medicine at Mount Sinai, 1971 - 1972
  • Residency, General Internal Medicine, University of Missouri - Columbia School of Medicine, 1197
  • Fellowship, Infectious Diseases, Duke University School of Medicine, 1197
  • M.D., Northwestern University, 1971

Publications

Chen, LF, Anderson, DJ, Kaye, KS, and Sexton, DJ. "Validating a 3-point prediction rule for surgical site infection after coronary artery bypass surgery." Infect Control Hosp Epidemiol 31, no. 1 (January 2010): 64-68.

PMID
19911975
Full Text

Herzke, C, Chen, LF, Anderson, DJ, Choi, Y, Sexton, DJ, and Kaye, KS. "Reply to fe talento et al." Infection Control and Hospital Epidemiology 31, no. 9 (2010): 983-985.

Full Text

Anderson, DJ, Kaye, KS, Chen, LF, Schmader, KE, Choi, Y, Sloane, R, and Sexton, DJ. "Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study. (Published online)" PLoS One 4, no. 12 (December 15, 2009): e8305-.

PMID
20016850
Full Text

Herzke, CA, Chen, LF, Anderson, DJ, Choi, Y, Sexton, DJ, and Kaye, KS. "Empirical antimicrobial therapy for bloodstream infection due to methicillin-resistant Staphylococcus aureus: no better than a coin toss." Infect Control Hosp Epidemiol 30, no. 11 (November 2009): 1057-1061.

PMID
19803766
Full Text

Kanafani, ZA, Sexton, DJ, Pien, BC, Varkey, J, Basmania, C, and Kaye, KS. "Postoperative joint infections due to Propionibacterium species: a case-control study." Clin Infect Dis 49, no. 7 (October 1, 2009): 1083-1085.

PMID
19725786
Full Text

Freeman, JT, Anderson, DJ, and Sexton, DJ. "Seasonal peaks in Escherichia coli infections: possible explanations and implications." Clin Microbiol Infect 15, no. 10 (October 2009): 951-953.

PMID
19845705
Full Text

Chen, LF, Sexton, DJ, Kaye, KS, and Anderson, DJ. "Patient-days: a better measure of incidence of occupational bloodborne exposures." Am J Infect Control 37, no. 7 (September 2009): 534-540.

PMID
19520459
Full Text

Sexton, DJ, Chen, T, Martik, D, Kuzmic, P, Kuang, G, Chen, J, Nixon, AE, Zuraw, BL, Forteza, RM, Abraham, WM, and Wood, CR. "Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. (Published online)" Biochem J 422, no. 2 (August 13, 2009): 383-392.

PMID
19527222
Full Text

Freeman, J, Anderson, D, and Sexton, DJ. "Emerging evidence for seasonality of gram-negative bacterial infections." Infect Control Hosp Epidemiol 30, no. 8 (August 2009): 813-814. (Letter)

PMID
19591590
Full Text

Freeman, JT, Sexton, DJ, and Anderson, DJ. "Emergence of extended-spectrum beta-lactamase-producing Escherichia coli in community hospitals throughout North Carolina: a harbinger of a wider problem in the United States?." Clin Infect Dis 49, no. 2 (July 15, 2009): e30-e32.

PMID
19522654
Full Text

Pages