David A D'Alessio, MD

Professor of Medicine
Chief, Division of Endocrinology and Metabolism
Member of Duke Molecular Physiology Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 684-4005
Email address david.d'alessio@duke.edu

Education and Training

  • Research Fellowship, Metabolism, Endocrinology And Nutrition, University of Washington School of Medicine, 1987 - 1990
  • Resident, Temple University School of Medicine, 1983 - 1986
  • M.D., University of Wisconsin at Madison, 1983

Publications

Elder, DA, Hornung, LN, Herbers, PM, Prigeon, R, Woo, JG, and D'Alessio, DA. "Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes." Journal of Pediatrics 166, no. 3 (January 1, 2015): 672-678.

Full Text

Vahl, TP, Aulinger, BA, Smith, EP, Drazen, DL, Ulrich-Lai, Y, Seeley, RJ, Woods, SC, and D'Alessio, DA. "Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia." American journal of physiology. Endocrinology and metabolism 307, no. 9 (November 2014): E784-E792.

PMID
25159330
Full Text

Salehi, M, and D'Alessio, DA. "Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery." Reviews in endocrine & metabolic disorders 15, no. 3 (September 2014): 171-179. (Review)

PMID
24951252
Full Text

Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Evidence from a single individual that increased plasma GLP-1 and GLP-1-stimulated insulin secretion after gastric bypass are independent of foregut exclusion." Diabetologia 57, no. 7 (July 2014): 1495-1499.

PMID
24797288
Full Text

Tong, J, Davis, HW, Summer, S, Benoit, SC, Haque, A, Bidlingmaier, M, Tschöp, MH, and D'Alessio, D. "Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans." Diabetes 63, no. 7 (July 2014): 2309-2319.

PMID
24550190
Full Text

Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia." The Journal of Clinical Endocrinology and Metabolism 99, no. 6 (June 2014): 2008-2017.

PMID
24617664
Full Text

Sisley, S, Gutierrez-Aguilar, R, Scott, M, D'Alessio, DA, Sandoval, DA, and Seeley, RJ. "Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect." The Journal of clinical investigation 124, no. 6 (June 2014): 2456-2463.

PMID
24762441
Full Text

Smith, EP, An, Z, Wagner, C, Lewis, AG, Cohen, EB, Li, B, Mahbod, P, Sandoval, D, Perez-Tilve, D, Tamarina, N, Philipson, LH, Stoffers, DA, Seeley, RJ, and D'Alessio, DA. "The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs." Cell metabolism 19, no. 6 (June 2014): 1050-1057.

PMID
24836562
Full Text

Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Beta-Cell Response to Graded up & Down Glucose Infusion after Gastric Bypass Surgery." ENDOCRINE REVIEWS 35, no. 3 (June 2014).

Scholars@Duke

Gastaldelli, A, Brodows, RG, and D'Alessio, D. "The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes." Clinical endocrinology 80, no. 4 (April 2014): 545-553.

PMID
23574529
Full Text

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