David James Easterhoff, PhD

Assistant Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Durham, NC 27710
Phone (919) 681-9099
Email address david.easterhoff@duke.edu

Education and Training

  • Ph.D., University of Rochester School of Medicine and Denistry, 2013
  • M.S., University of Rochester School of Medicine and Denistry, 2011

Publications

Pollara, J, Easterhoff, D, and Fouda, GG. "Lessons learned from human HIV vaccine trials." Current Opinion in Hiv and Aids 12, no. 3 (May 2017): 216-221. (Review)

PMID
28230655
Full Text

Ding, S, Verly, MM, Princiotto, A, Melillo, B, Moody, AM, Bradley, T, Easterhoff, D, Roger, M, Hahn, BH, Madani, N, Smith, AB, Haynes, BF, Sodroski, J, and Finzi, A. "Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates." Aids Research and Human Retroviruses 33, no. 5 (May 2017): 428-431.

PMID
27846736
Full Text

Easterhoff, D, Moody, MA, Fera, D, Cheng, H, Ackerman, M, Wiehe, K, Saunders, KO, Pollara, J, Vandergrift, N, Parks, R, Kim, J, Michael, NL, O'Connell, RJ, Excler, J-L, Robb, ML, Vasan, S, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Nitayaphan, S, Sinangil, F, Tartaglia, J, Phogat, S, Kepler, TB, Alam, SM, Liao, H-X, Ferrari, G, Seaman, MS, Montefiori, DC, Tomaras, GD, Harrison, SC, and Haynes, BF. "Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial." Plos Pathogens 13, no. 2 (February 24, 2017): e1006182-null.

PMID
28235027
Full Text

Luo, K, Liao, H-X, Zhang, R, Easterhoff, D, Wiehe, K, Gurley, TC, Armand, LC, Allen, AA, Von Holle, TA, Marshall, DJ, Whitesides, JF, Pritchett, J, Foulger, A, Hernandez, G, Parks, R, Lloyd, KE, Stolarchuk, C, Sawant, S, Peel, J, Yates, NL, Dunford, E, Arora, S, Wang, A, Bowman, CM, Sutherland, LL, Scearce, RM, Xia, S-M, Bonsignori, M, Pollara, J, Edwards, RW, Santra, S, Letvin, NL, Tartaglia, J, Francis, D, Sinangil, F, Lee, C, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, and Rerks-Ngarm, S et al. "Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques." JCI insight 1, no. 20 (December 8, 2016): e88522-.

PMID
27942585
Full Text

Madani, N, Princiotto, AM, Easterhoff, D, Bradley, T, Luo, K, Williams, WB, Liao, H-X, Moody, MA, Phad, GE, Vázquez Bernat, N, Melillo, B, Santra, S, Smith, AB, Karlsson Hedestam, GB, Haynes, B, and Sodroski, J. "Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds." Journal of Virology 90, no. 10 (May 2016): 5031-5046.

PMID
26962221
Full Text

Wiehe, K, Easterhoff, D, Luo, K, Nicely, NI, Bradley, T, Jaeger, FH, Dennison, SM, Zhang, R, Lloyd, KE, Stolarchuk, C, Parks, R, Sutherland, LL, Scearce, RM, Morris, L, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Sinangil, F, Phogat, S, Michael, NL, Kim, JH, Kelsoe, G, Montefiori, DC, Tomaras, GD, Bonsignori, M, Santra, S, Kepler, TB, Alam, SM, Moody, MA, Liao, H-X, and Haynes, BF. "Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved." Immunity 41, no. 6 (December 2014): 909-918.

PMID
25526306
Full Text

Moody, MA, Easterhoff, D, Gurley, TC, Whitesides, JF, Marshall, DJ, Foulger, A, Lloyd, KE, Parks, R, Pollara, J, Duffy, R, Shen, S, Kim, JH, Michael, NL, Robb, ML, O'Connell, RJ, Vasan, S, Excler, JL, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Nitayaphan, S, Sinangil, F, Francis, D, Lee, C, Kepler, TB, Alam, SM, Ferrari, G, Montefiori, DC, Liao, HX, Tomaras, GD, and Haynes, BF. "Induction of Antibodies with Long Variable Heavy Third Complementarity Determining Regions by Repetitive Boosting with AIDSVAX® B/E in RV144 Vaccinees." October 2014.

PMID
25357837
Full Text

Moody, MA, Santra, S, Vandergrift, NA, Sutherland, LL, Gurley, TC, Drinker, MS, Allen, AA, Xia, S-M, Meyerhoff, RR, Parks, R, Lloyd, KE, Easterhoff, D, Alam, SM, Liao, H-X, Ward, BM, Ferrari, G, Montefiori, DC, Tomaras, GD, Seder, RA, Letvin, NL, and Haynes, BF. "Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques." Journal of Virology 88, no. 6 (March 2014): 3329-3339.

PMID
24390332
Full Text

Easterhoff, D, DiMaio, JTM, Liyanage, W, Lo, C-W, Bae, W, Doran, TM, Smrcka, A, Nilsson, BL, and Dewhurst, S. "Fluorescence detection of cationic amyloid fibrils in human semen." Bioorganic & Medicinal Chemistry Letters 23, no. 18 (September 2013): 5199-5202.

PMID
23910594
Full Text