David James Easterhoff, PhD

Assistant Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Durham, NC 27710
Phone (919) 681-9099
Email address david.easterhoff@duke.edu

Education and Training

  • Ph.D., University of Rochester School of Medicine and Denistry, 2013
  • M.S., University of Rochester School of Medicine and Denistry, 2011

Publications

Bonsignori, M, Scott, E, Wiehe, K, Easterhoff, D, Alam, SM, Hwang, K-K, Cooper, M, Xia, S-M, Zhang, R, Montefiori, DC, Henderson, R, Nie, X, Kelsoe, G, Moody, MA, Chen, X, Joyce, MG, Kwong, PD, Connors, M, Mascola, JR, McGuire, AT, Stamatatos, L, Medina-Ramírez, M, Sanders, RW, Saunders, KO, Kepler, TB, and Haynes, BF. "Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier." Immunity 49, no. 6 (December 11, 2018): 1162-1174.e8.

PMID
30552024
Full Text

Bonsignori, M, Scott, E, Wiehe, K, Easterhoff, D, Alam, SM, Hwang, K-K, Montefiori, DC, Henderson, R, Chen, X, Joyce, MG, Kwong, PD, Connors, M, Mascola, JR, McGuire, AT, Stamatatos, L, Medina-Ramirez, M, Sanders, RW, Saunders, KO, Kepler, TB, and Haynes, BF. "Dual Maturation Pathways from the Unmutated Common Ancestor of HIV-1 Envelope Broadly Neutralizing Antibodies Overcome Glycan Barriers." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Williams, L, Tay, MZ, Shen, X, Sawant, S, Dahora, L, Yates, N, Easterhoff, D, Robb, M, O'Connell, R, Vasan, S, Rerks-Ngarm, S, Pitisuttithum, P, Nitayaphan, S, deCamp, A, Phogat, S, Sinangil, F, Pollara, J, Haynes, B, Ferrari, G, and Tomaras, G. "Delayed and Repetitive Boosting of RV144 Vaccinees Improves Antiviral Immunity Associated With Correlates of HIV-1 Infection Risk." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Peachman, K, Easterhoff, D, Akapirat, S, Rerks-Ngarm, S, Pittisuttithum, P, Nitayaphan, S, Phogat, S, Sinangil, F, Haynes, B, O'Connell, R, Robb, M, Michael, N, Vasan, S, and Rao, M. "Prolonged Intervals Between Boosts Induces High Magnitude Transient V2-specific Functional Antibodies That Inhibit the Binding of V2 to alpha 4 beta 7 Integrin." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Wiehe, K, Bradley, T, Meyerhoff, RR, Hart, C, Williams, WB, Easterhoff, D, Faison, WJ, Kepler, TB, Saunders, KO, Alam, SM, Bonsignori, M, and Haynes, BF. "Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development." Cell Host & Microbe 23, no. 6 (June 2018): 759-765.e6.

PMID
29861171
Full Text

Ding, S, Verly, MM, Princiotto, A, Melillo, B, Moody, AM, Bradley, T, Easterhoff, D, Roger, M, Hahn, BH, Madani, N, Smith, AB, Haynes, BF, Sodroski, J, and Finzi, A. "Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates." Aids Research and Human Retroviruses 33, no. 5 (May 2017): 428-431.

PMID
27846736
Full Text

Pollara, J, Easterhoff, D, and Fouda, GG. "Lessons learned from human HIV vaccine trials." Current Opinion in Hiv and Aids 12, no. 3 (May 2017): 216-221. (Review)

PMID
28230655
Full Text

Easterhoff, D, Moody, MA, Fera, D, Cheng, H, Ackerman, M, Wiehe, K, Saunders, KO, Pollara, J, Vandergrift, N, Parks, R, Kim, J, Michael, NL, O'Connell, RJ, Excler, J-L, Robb, ML, Vasan, S, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Nitayaphan, S, Sinangil, F, Tartaglia, J, Phogat, S, Kepler, TB, Alam, SM, Liao, H-X, Ferrari, G, Seaman, MS, Montefiori, DC, Tomaras, GD, Harrison, SC, and Haynes, BF. "Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial." Plos Pathogens 13, no. 2 (February 24, 2017): e1006182-null.

PMID
28235027
Full Text

Luo, K, Liao, H-X, Zhang, R, Easterhoff, D, Wiehe, K, Gurley, TC, Armand, LC, Allen, AA, Von Holle, TA, Marshall, DJ, Whitesides, JF, Pritchett, J, Foulger, A, Hernandez, G, Parks, R, Lloyd, KE, Stolarchuk, C, Sawant, S, Peel, J, Yates, NL, Dunford, E, Arora, S, Wang, A, Bowman, CM, Sutherland, LL, Scearce, RM, Xia, S-M, Bonsignori, M, Pollara, J, Edwards, RW, Santra, S, Letvin, NL, Tartaglia, J, Francis, D, Sinangil, F, Lee, C, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Michael, NL, Kim, JH, Alam, SM, Vandergrift, NA, Ferrari, G, Montefiori, DC, Tomaras, GD, Haynes, BF, and Moody, MA. "Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques." Jci Insight 1, no. 20 (December 8, 2016): e88522-null.

PMID
27942585
Full Text

Madani, N, Princiotto, A, Easterhoff, D, Bradley, T, Luo, K, Moody, MA, Phad, G, Bernat, NV, Melillo, B, Santra, S, Ma, Z-M, Fritts, L, Dutra, J, Vrbanac, V, Tager, A, Smith, A, Hedestam, GK, Haynes, B, Miller, C, and Sodroski, J. "Prevention of Vaginal Transmission of Simian-Human Immunodeficiency Virus (SHIV) in Rhesus Monkeys by Small-molecule CD4-mimetic Compounds." Conference on HIV Research for Prevention (HIV R4P). Chicago, IL. October 17, 2016 - October 20, 2016. MARY ANN LIEBERT, INC, October 1, 2016.

Scholars@Duke

Pages