
Deb Muoio is professor in the Departments of Medicine and Pharmacology & Cancer Biology, George Barth Geller Distinguished Professor of Cardiovascular Disease, and Director of Basic Science Research at the Duke Molecular Physiology Institute (DMPI). She is viewed nationally and internationally as a leader in the fields of diabetes, obesity, exercise physiology, and mitochondrial energy metabolism. Her laboratory investigates mechanisms of metabolic regulation, with emphasis on molecular events that link lifestyle factors such as over nutrition and physical inactivity to metabolic disorders, including obesity, diabetes, and heart failure. Her program features a translational approach that combines work in animal and cell-based models with human studies, using genetic engineering, molecular biology and mass spectrometry-based metabolomics and proteomics as tools to understand the interplay between mitochondrial physiology and cardiometabolic health. Her laboratory developed a sophisticated platform for deep and comprehensive assessment of mitochondrial bioenergetics and energy transduction. Her team is integrating this new platform with metabolomics, proteomics, and metabolic flux analysis to gain insights into mechanisms by which mitochondria modulate insulin action and metabolic resilience. She has published more than 120 papers in prominent journals such as Cell, Cell Metabolism, Circulation, Circulation Research, Diabetes, and JCI Insight. Dr. Muoio’s laboratory has enjoyed longstanding support from the NIDDK and NHLBI.
PhD, University of North Carolina, Chapel Hill, NC
Education and Training
- Ph.D., University of North Carolina - Chapel Hill, 1999
Grants
- Medical Scientist Training Program
- Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
- Duke Center for Advancement of Child Health (CAtCH).
- Microbial regulation of intestinal lipid metabolism and its physiological consequences
- Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss
- Accelerated Metabolic Aging in Rheumatoid Arthritis Immune cells and Skeletal Muscle: A Pilot Study
- The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells
- Mechanisms of lipid-induced bioenergetic stress in muscle
- STIM1 and mitochondrial quality control
- Multidisciplinary Heart and Vascular Diseases
- Role of cardiac and skeletal muscle ketone oxidation in permitting adaptive mitochondrial remodeling in response to lipid stress
- Propionyl-CoA and propionycarnitine-mediated cardiac complication in patients with propionic acidemia