Deborah Marie Muoio, PhD

Professor of Medicine
George Barth Geller Distinguished Professor of Cardiovascular Disease
Professor in Pharmacology and Cancer Biology
Member of Sarah W. Stedman Nutrition and Metabolism Center
Member of the Duke Cancer Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 479-2328
Email address muoio@duke.edu

Deb Muoio is professor in the Departments of Medicine and Pharmacology & Cancer Biology, George Barth Geller Distinguished Professor of Cardiovascular Disease, and Director of Basic Science Research at the Duke Molecular Physiology Institute (DMPI). She is viewed nationally and internationally as a leader in the fields of diabetes, obesity, exercise physiology, and mitochondrial energy metabolism. Her laboratory investigates mechanisms of metabolic regulation, with emphasis on molecular events that link lifestyle factors such as over nutrition and physical inactivity to metabolic disorders, including obesity, diabetes, and heart failure. Her program features a translational approach that combines work in animal and cell-based models with human studies, using genetic engineering, molecular biology and mass spectrometry-based metabolomics and proteomics as tools to understand the interplay between mitochondrial physiology and cardiometabolic health. Her laboratory developed a sophisticated platform for deep and comprehensive assessment of mitochondrial bioenergetics and energy transduction. Her team is integrating this new platform with metabolomics, proteomics, and metabolic flux analysis to gain insights into mechanisms by which mitochondria modulate insulin action and metabolic resilience. She has published more than 120 papers in prominent journals such as Cell, Cell Metabolism, Circulation, Circulation Research, Diabetes, and JCI Insight. Dr. Muoio’s laboratory has enjoyed longstanding support from the NIDDK and NHLBI.

PhD, University of North Carolina, Chapel Hill, NC

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 1999

Publications

Andonian, Brian J., Alec Koss, Timothy R. Koves, Elizabeth R. Hauser, Monica J. Hubal, David M. Pober, Janet M. Lord, et al. “Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.” Sci Rep 12, no. 1 (May 6, 2022): 7450. https://doi.org/10.1038/s41598-022-11458-4.

PMID
35523821
Full Text

Wilson, Rebecca J., Scott P. Lyons, Timothy R. Koves, Victoria G. Bryson, Hengtao Zhang, TianYu Li, Scott B. Crown, et al. “Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass.” Mol Metab 57 (March 2022): 101429. https://doi.org/10.1016/j.molmet.2021.101429.

PMID
34979330
Full Text

Williams, Ashley S., Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, and Deborah M. Muoio. “Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.” Iscience 25, no. 1 (January 21, 2022): 103635. https://doi.org/10.1016/j.isci.2021.103635.

PMID
35028529
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Zhang, Hengtao, Victoria Graham Bryson, Chaojian Wang, TianYu Li, Jaclyn P. Kerr, Rebecca Wilson, Deborah M. Muoio, Robert J. Bloch, Christopher Ward, and Paul B. Rosenberg. “Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle.” Jci Insight 6, no. 17 (September 8, 2021). https://doi.org/10.1172/jci.insight.143472.

PMID
34494555
Full Text

Chambers, Kari T., Michael A. Cooper, Alison R. Swearingen, Rita T. Brookheart, George G. Schweitzer, Carla J. Weinheimer, Attila Kovacs, et al. “Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.” Jci Insight 6, no. 9 (May 10, 2021). https://doi.org/10.1172/jci.insight.134340.

PMID
33986192
Full Text

White, Phillip J., Amanda L. Lapworth, Robert W. McGarrah, Lydia Coulter Kwee, Scott B. Crown, Olga Ilkayeva, Jie An, et al. “Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.” Cell Rep 33, no. 6 (November 10, 2020): 108375. https://doi.org/10.1016/j.celrep.2020.108375.

PMID
33176135
Full Text

McCommis, Kyle S., Attila Kovacs, Carla J. Weinheimer, Trevor M. Shew, Timothy R. Koves, Olga R. Ilkayeva, Dakota R. Kamm, et al. “Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice.” Nat Metab 2, no. 11 (November 2020): 1232–47. https://doi.org/10.1038/s42255-020-00296-1.

PMID
33106690
Full Text

Davidson, Michael T., Paul A. Grimsrud, Ling Lai, James A. Draper, Kelsey H. Fisher-Wellman, Tara M. Narowski, Dennis M. Abraham, Timothy R. Koves, Daniel P. Kelly, and Deborah M. Muoio. “Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.” Circ Res 127, no. 8 (September 25, 2020): 1094–1108. https://doi.org/10.1161/CIRCRESAHA.120.317293.

PMID
32660330
Full Text

Yurdagul, Arif, Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, et al. “Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.” Cell Metab 31, no. 3 (March 3, 2020): 518-533.e10. https://doi.org/10.1016/j.cmet.2020.01.001.

PMID
32004476
Full Text

Williams, Ashley S., Timothy R. Koves, Michael T. Davidson, Scott B. Crown, Kelsey H. Fisher-Wellman, Maria J. Torres, James A. Draper, et al. “Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.” Cell Metab 31, no. 1 (January 7, 2020): 131-147.e11. https://doi.org/10.1016/j.cmet.2019.11.003.

PMID
31813822
Full Text

Pages