Deborah Marie Muoio, PhD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Member of Sarah W. Stedman Nutrition and Metabolism Center
Member of the Duke Cancer Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 479-2328
Email address muoio@duke.edu

Deb Muoio is a Professor of Medicine, Division of Endocrinology, and Director of Basic Research at the Duke Molecular Physiology Institute. She earned a PhD in Nutritional Biochemistry at the University of North Carolina, Chapel Hill, followed by postdoctoral fellowships at East Carolina and Duke Universities working in the areas of muscle physiology and metabolic disease. Her laboratory studies mechanisms of metabolic control and molecular events that link nutrition and exercise to health outcomes. Her research program features a translational approach that combines basic science and human studies with mass spectrometry-based metabolomics to identify metabolite signatures of mitochondrial dysfunction and cardiometabolic disease. The overarching goal of this work is to guide the development of new lifestyle, nutraceutical and/or pharmacological strategies to maintain mitochondrial and metabolic health. 

PhD, University of North Carolina, Chapel Hill, NC

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 1999

Publications

Yurdagul, Arif, Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, et al. “Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.” Cell Metab 31, no. 3 (March 3, 2020): 518-533.e10. https://doi.org/10.1016/j.cmet.2020.01.001.

PMID
32004476
Full Text

Williams, Ashley S., Timothy R. Koves, Michael T. Davidson, Scott B. Crown, Kelsey H. Fisher-Wellman, Maria J. Torres, James A. Draper, et al. “Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.” Cell Metab 31, no. 1 (January 7, 2020): 131-147.e11. https://doi.org/10.1016/j.cmet.2019.11.003.

PMID
31813822
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Bruls, Yvonne Mh, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, et al. “Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial.” Ebiomedicine 49 (November 2019): 318–30. https://doi.org/10.1016/j.ebiom.2019.10.017.

PMID
31676389
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Ho, Kim L., Liyan Zhang, Cory Wagg, Rami Al Batran, Keshav Gopal, Jody Levasseur, Teresa Leone, et al. “Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.” Cardiovasc Res 115, no. 11 (September 1, 2019): 1606–16. https://doi.org/10.1093/cvr/cvz045.

PMID
30778524
Full Text

Lin, Kevin H., Abigail Xie, Justine C. Rutter, Yeong-Ran Ahn, Julia M. Lloyd-Cowden, Amanda G. Nichols, Ryan S. Soderquist, et al. “Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.” Cell Metab 29, no. 5 (May 7, 2019): 1217-1231.e7. https://doi.org/10.1016/j.cmet.2019.01.011.

PMID
30773463
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Khodabukus, Alastair, Lauran Madden, Neel K. Prabhu, Timothy R. Koves, Christopher P. Jackman, Deborah M. Muoio, and Nenad Bursac. “Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.” Biomaterials 198 (April 2019): 259–69. https://doi.org/10.1016/j.biomaterials.2018.08.058.

PMID
30180985
Full Text

Haldeman, Jonathan M., Amanda E. Conway, Michelle E. Arlotto, Dorothy H. Slentz, Deborah M. Muoio, Thomas C. Becker, and Christopher B. Newgard. “Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.” Nucleic Acids Res 47, no. 4 (February 28, 2019): e23. https://doi.org/10.1093/nar/gky1286.

PMID
30590691
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Horton, Julie L., Michael T. Davidson, Clara Kurishima, Rick B. Vega, Jeffery C. Powers, Timothy R. Matsuura, Christopher Petucci, et al. “The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.” Jci Insight 4, no. 4 (February 21, 2019). https://doi.org/10.1172/jci.insight.124079.

PMID
30668551
Full Text

Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.

PMID
30726738
Full Text

Wang, Yingxue, Bridgette A. Christopher, Kirkland A. Wilson, Deborah Muoio, Robert W. McGarrah, Henri Brunengraber, and Guo-Fang Zhang. “Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine.” Am J Physiol Endocrinol Metab 315, no. 4 (October 1, 2018): E622–33. https://doi.org/10.1152/ajpendo.00081.2018.

PMID
30016154
Full Text

Pages