Derek Wilson Cain, PhD

Associate Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct - Rm 4083 MSRBII, Durham, NC 27710
Phone (919) 681-8193

My research focuses on the interactions of T cells and B cells during infection or following vaccination. I am particularly interested in the inter- and intracellular events that take place within germinal centers, the anatomic site of antibody evolution during an immune response.

Education and Training

  • Ph.D., Duke University, 2010

Publications

Cain, Derek W., and John A. Cidlowski. “Specificity and sensitivity of glucocorticoid signaling in health and disease.” Best Pract Res Clin Endocrinol Metab 29, no. 4 (August 2015): 545–56. https://doi.org/10.1016/j.beem.2015.04.007.

PMID
26303082
Full Text

Kim, Mikyung, Likai Song, James Moon, Zhen-Yu J. Sun, Anna Bershteyn, Melissa Hanson, Derek Cain, et al. “Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.” J Biol Chem 288, no. 44 (November 1, 2013): 31888–901. https://doi.org/10.1074/jbc.M113.494609.

PMID
24047898
Full Text

Cain, Derek W., Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn, and Garnett Kelsoe. “Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.” J Immunol 191, no. 9 (November 1, 2013): 4665–75. https://doi.org/10.4049/jimmunol.1300581.

PMID
24078688
Full Text

Yang, Guang, T Matt Holl, Yang Liu, Yi Li, Xiaozhi Lu, Nathan I. Nicely, Thomas B. Kepler, et al. “Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.” J Exp Med 210, no. 2 (February 11, 2013): 241–56. https://doi.org/10.1084/jem.20121977.

PMID
23359068
Full Text

Cain, Derek W., Sergio E. Sanders, Michael M. Cunningham, and Garnett Kelsoe. “Disparate adjuvant properties among three formulations of "alum".” Vaccine 31, no. 4 (January 11, 2013): 653–60. https://doi.org/10.1016/j.vaccine.2012.11.044.

PMID
23200935
Full Text

Cain, Derek W., and Michael D. Gunn. “NUR who? An orphan transcription factor holds promise for monomaniacs.” Nat Immunol 12, no. 8 (July 19, 2011): 727–29. https://doi.org/10.1038/ni.2074.

PMID
21772283
Full Text

Kuraoka, Masayuki, T Matt Holl, Dongmei Liao, Mandy Womble, Derek W. Cain, Alexander E. Reynolds, and Garnett Kelsoe. “Activation-induced cytidine deaminase mediates central tolerance in B cells.” Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11560–65. https://doi.org/10.1073/pnas.1102571108.

PMID
21700885
Full Text

Cain, Derek W., Pilar B. Snowden, Gregory D. Sempowski, and Garnett Kelsoe. “Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.” Plos One 6, no. 5 (2011): e19957. https://doi.org/10.1371/journal.pone.0019957.

PMID
21655273
Full Text

Ledford, Julie G., Bernice Lo, Michele M. Kislan, Joseph M. Thomas, Katherine Evans, Derek W. Cain, Monica Kraft, Kristi L. Williams, and Jo Rae Wright. “Surfactant protein-A inhibits mycoplasma-induced dendritic cell maturation through regulation of HMGB-1 cytokine activity.” J Immunol 185, no. 7 (October 1, 2010): 3884–94. https://doi.org/10.4049/jimmunol.1000387.

PMID
20810986
Full Text

Pages