Diego V. Bohorquez, PhD

Assistant Professor in Medicine
Assistant Professor in Pathology
Assistant Research Professor in Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail Box 2651 - 221A Msrbi, 203 Research Dr, Durham, NC 27710
Phone (919) 684-4520
Email address diego.bohorquez@duke.edu

I am a gut-brain neuroscientist.

Though my initial studies focused on GI physiology and nutrition, my expertise evolved to include neuroscience following the many personal stories, which have carefully sharpened my career vision along the way.  While pursuing a Doctoral degree in Nutrition, a friend shared her struggles with obesity and gastric bypass surgery.  

Surgery was a last resort but helped to reduced her body weight dramatically and resolved her diabetes.  Yet, the most striking part of her story for me was that her perception of taste had been markedly transformed. Reshaping her gut caused her brain to convert a prior repulsion at the appearance of runny egg yolk into a strong craving to eat those same eggs.

Today, we are still a long way from understanding the full details of these intriguing conversations between our gut and our brain. But, the more we understand, the closer we are getting to treating disorders involving alterations in the perception of food in our gut.

My focus is to unveil how the brain perceives what the gut feels, how food in the intestine is sensed by our body, and how a sensory signal from a nutrient is transformed into an electrical signal that alters behavior.

Education and Training

  • 2014 Grass Fellow in the Neurosciences at the Marine Biology Laboratory, Marine Biology Laboratory, Woods Hole, Ma, -, 2014 - 2014
  • Postdoctoral Fellow in Neurogastroenterology, Duke University Medical Center, Duke University School of Medicine, 2010 - 2014
  • Ph.D., North Carolina State University, 2010

Publications

Bohórquez, Diego V., Leigh A. Samsa, Andrew Roholt, Satish Medicetty, Rashmi Chandra, and Rodger A. Liddle. “An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy..” Plos One 9, no. 2 (2014). https://doi.org/10.1371/journal.pone.0089881.

PMID
24587096
Full Text

Bohórquez, D. V., N. E. Bohórquez, and P. R. Ferket. “Ultrastructural development of the small intestinal mucosa in the embryo and turkey poult: A light and electron microscopy study..” Poult Sci 90, no. 4 (April 2011): 842–55. https://doi.org/10.3382/ps.2010-00939.

PMID
21406371
Full Text

Bohórquez, Diego V., Rashmi Chandra, Leigh Ann Samsa, Steven R. Vigna, and Rodger A. Liddle. “Characterization of basal pseudopod-like processes in ileal and colonic PYY cells..” J Mol Histol 42, no. 1 (February 2011): 3–13. https://doi.org/10.1007/s10735-010-9302-6.

PMID
21061049
Full Text

Pages