Ephraim Tsalik, MD, PhD

Associate Professor of Medicine
Associate Professor in the Department of Molecular Genetics and Microbiology
Campus mail Box 102359 DUMC, Durham, NC 27710
Phone (919) 684-3114
Email address e.t@duke.edu

My research is focused on understanding the dynamic between host and pathogen so as to discover and develop host-response markers that can diagnose and predict health and disease.  This new and evolving approach to diagnosing illness has the potential to significantly impact individual as well as public health considering the rise of antibiotic resistance.

With any potential infectious disease diagnosis, it is difficult, if not impossible, to determine at the time of presentation what the underlying cause of illness is.  For example, acute respiratory illness is among the most frequent reasons for patients to seek care. These symptoms, such as cough, sore throat, and fever may be due to a bacterial infection, viral infection, both, or a non-infectious condition such as asthma or allergies.  Given the difficulties in making the diagnosis, most patients are inappropriately given antibacterials.  However, each of these etiologies (bacteria, virus, or something else entirely) leaves a fingerprint embedded in the host’s response. We are very interested in finding those fingerprints and exploiting them to generate new approaches to understand, diagnose, and manage disease.

These principles also apply to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Just as with acute respiratory illness, it is often difficult to identify whether infection is responsible for a patient’s critical illness.  We have embarked on a number of research programs that aim to better identify sepsis; define sepsis subtypes that can be used to guide future clinical research; and to better predict sepsis outcomes.  These efforts have focused on many systems biology modalities including transcriptomics, miRNA, metabolomics, and proteomics.  Consequently, our Data Science team has utilized these highly complex data to develop new statistical methods, furthering both the clinical and statistical research communities.

Synergy between multi-disciplinary experts is crucial to tackle the threats posed by infectious diseases and the rise in antimicrobial resistance. We have successfully assembled a team of clinical scientists, data scientists, laboratorians, clinical research coordinators, among many others. Potential collaborators are encouraged to contact us.

These examples are just a small sampling of the breadth of research Dr. Tsalik and his colleagues conduct.  Please visit https://precisionmedicine.duke.edu/ for more details.

Education and Training

  • Fellowship in Infectious Diseases, Medicine, Duke University School of Medicine, 2008 - 2011
  • Residency, Medicine, Duke University School of Medicine, 2005 - 2008
  • M.D., Columbia University College of Physicians and Surgeons, 2005
  • Ph.D., Columbia University College of Physicians and Surgeons, 2003

Publications

Yang, WE, Woods, CW, and Tsalik, EL. "Host-based diagnostics for detection and prognosis of infectious diseases." 42 (January 1, 2015): 465-500. (Chapter)

Full Text

Ko, ER, Yang, WE, McClain, MT, Woods, CW, Ginsburg, GS, and Tsalik, EL. "What was old is new again: using the host response to diagnose infectious disease." Expert Review of Molecular Diagnostics 15, no. 9 (January 2015): 1143-1158. (Review)

PMID
26145249
Full Text

Zaas, AK, Garner, BH, Tsalik, EL, Burke, T, Woods, CW, and Ginsburg, GS. "The current epidemiology and clinical decisions surrounding acute respiratory infections." Trends in Molecular Medicine 20, no. 10 (October 1, 2014): 579-588. (Review)

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Zaas, AK, Garner, BH, Tsalik, EL, Burke, T, Woods, CW, and Ginsburg, GS. "The current epidemiology and clinical decisions surrounding acute respiratory infections." Trends in Molecular Medicine 20, no. 10 (October 2014): 579-588. (Review)

PMID
25201713
Full Text

Langley, RJ, Tipper, JL, Bruse, S, Baron, RM, Tsalik, EL, Huntley, J, Rogers, AJ, Jaramillo, RJ, O'Donnell, D, Mega, WM, Keaton, M, Kensicki, E, Gazourian, L, Fredenburgh, LE, Massaro, AF, Otero, RM, Fowler, VG, Rivers, EP, Woods, CW, Kingsmore, SF, Sopori, ML, Perrella, MA, Choi, AMK, and Harrod, KS. "Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes." American Journal of Respiratory and Critical Care Medicine 190, no. 4 (August 2014): 445-455.

PMID
25054455
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Tsalik, EL. "Cardiovascular genetics: All systems point to TREML4." Science Translational Medicine 6, no. 246 (July 23, 2014).

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Tsalik, EL. "Antimicrobial drug resistance in all four corners of the earth." Science Translational Medicine 6, no. 240 (June 11, 2014).

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Yan, Q, Sharma-Kuinkel, BK, Deshmukh, H, Tsalik, EL, Cyr, DD, Lucas, J, Woods, CW, Scott, WK, Sempowski, GD, Thaden, JT, Rude, TH, Ahn, SH, and Fowler, VG. "Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis." Plos Pathogens 10, no. 6 (June 5, 2014): e1004149-null.

PMID
24901344
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Tsalik, EL. "The sum of one's parts? What our microbiomes say about us." Science Translational Medicine 6, no. 234 (April 30, 2014).

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Goswami, ND, Tsalik, EL, Naggie, S, Miller, WC, Horton, JR, Pfeiffer, CD, and Hicks, CB. "A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design." Trials 15 (January 22, 2014): 31-.

PMID
24450313
Full Text

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