Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Family Medicine and Community Health
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Østbye, Truls, Marissa Stroo, Eric L. Eisenstein, Bercedis Peterson, and John Dement. “Is overweight and class I obesity associated with increased health claims costs?.” Obesity (Silver Spring) 22, no. 4 (April 2014): 1179–86. https://doi.org/10.1002/oby.20669.

PMID
24796000
Full Text

Carter, Barry L., Elizabeth A. Chrischilles, Gary Rosenthal, Brian M. Gryzlak, Eric L. Eisenstein, and Mark W. Vander Weg. “Efficacy and safety of nighttime dosing of antihypertensives: review of the literature and design of a pragmatic clinical trial..” J Clin Hypertens (Greenwich) 16, no. 2 (February 2014): 115–21. https://doi.org/10.1111/jch.12238.

PMID
24373519
Full Text

Swigris, Jeffrey J., David L. Streiner, Kevin K. Brown, Amanda Belkin, Kathy E. Green, Frederick S. Wamboldt, and Frederick S. IPFnet Investigators. “Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis..” Respir Med 108, no. 1 (January 2014): 181–88. https://doi.org/10.1016/j.rmed.2013.12.009.

PMID
24388667
Full Text

Eisenstein, Elizabeth L. “Off Dutch presses.” Tls the Times Literary Supplement, no. 5758 (August 9, 2013): 6–6.

Scholars@Duke

Eisenstein, Eric L., Linda Davidson-Ray, Rex Edwards, Kevin J. Anstrom, and Kenneth Ouriel. “Economic analysis of endovascular repair versus surveillance for patients with small abdominal aortic aneurysms..” J Vasc Surg 58, no. 2 (August 2013): 302–10. https://doi.org/10.1016/j.jvs.2013.01.038.

PMID
23562339
Full Text

Collard, Harold R., Eric Yow, Luca Richeldi, Kevin J. Anstrom, Craig Glazer, and Craig IPFnet investigators. “Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials..” Respir Res 14 (July 13, 2013). https://doi.org/10.1186/1465-9921-14-73.

PMID
23848435
Full Text

Østbye, Truls, Marissa Stroo, Rebecca J. N. Brouwer, Bercedis L. Peterson, Eric L. Eisenstein, Bernard F. Fuemmeler, Julie Joyner, Libby Gulley, and John M. Dement. “The steps to health employee weight management randomized control trial: rationale, design and baseline characteristics..” Contemp Clin Trials 35, no. 2 (July 2013): 68–76. https://doi.org/10.1016/j.cct.2013.04.007.

PMID
23648394
Full Text

Lobach, David F., Kensaku Kawamoto, Kevin J. Anstrom, Garry M. Silvey, Janese M. Willis, Fred S. Johnson, Rex Edwards, et al. “A randomized trial of population-based clinical decision support to manage health and resource use for Medicaid beneficiaries..” J Med Syst 37, no. 1 (February 2013). https://doi.org/10.1007/s10916-012-9922-3.

PMID
23321963
Full Text

Willis, Janese M., Rex Edwards, Kevin J. Anstrom, Fred S. Johnson, Guilherme Del Fiol, Kensaku Kawamoto, Nancy M Allen Lapointe, Eric L. Eisenstein, and David F. Lobach. “Decision support for evidence-based pharmacotherapy detects adherence problems but does not impact medication use..” Stud Health Technol Inform 183 (2013): 116–25.

PMID
23388267
Scholars@Duke

Willis JM, S. J., R. Edwards, K. J. Anstrom, F. S. Johnson, G. Del Fiol, K. Kawamoto, N. M. Allen lapointe, E. L. Eisenstein, and D. F. Lobach. “Decision Support for Evidence-Based Pharmacotherapy Detects Adherence Problems but Does Not Impact Medication Use.” In Enabling Health and Healthcare Through ICT, edited by Karen L. Courtney, Omid Shabestari, and Alexander Kuo, 183:116–25. IOS Press, 2013.

Scholars@Duke

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