Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Family Medicine and Community Health
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Hillegass, William B., Manesh R. Patel, Lloyd W. Klein, Hitinder S. Gurm, J Matthew Brennan, Kevin J. Anstrom, David Dai, et al. “Long-term outcomes of older diabetic patients after percutaneous coronary stenting in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008..” J Am Coll Cardiol 60, no. 22 (December 4, 2012): 2280–89. https://doi.org/10.1016/j.jacc.2012.08.993.

PMID
23194940
Full Text

Eisenstein, Eric L., Linda Davidson-Ray, Rex Edwards, Kevin J. Anstrom, Patricia A. Cowper, Daniel B. Mark, and Thomas R. Aversano. “Economic Outcomes of Percutaneous Coronary Intervention Performed at Sites With and Without On-Site Cardiac Surgery.” In Circulation, 126:2779–2779. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Eisenstein, Eric L., Daniel Wojdyla, Kevin J. Anstrom, J Matthew Brennan, Robert M. Califf, Eric D. Peterson, and Pamela S. Douglas. “Evaluating the impact of public health notification: Duke clopidogrel experience..” Circ Cardiovasc Qual Outcomes 5, no. 6 (November 2012): 767–74. https://doi.org/10.1161/CIRCOUTCOMES.111.963330.

PMID
23093562
Full Text

Swigris, Jeffrey J., Meilan Han, Rekha Vij, Imre Noth, Eric L. Eisenstein, Kevin J. Anstrom, Kevin K. Brown, and Diane Fairclough. “The UCSD shortness of breath questionnaire has longitudinal construct validity in idiopathic pulmonary fibrosis..” Respir Med 106, no. 10 (October 2012): 1447–55. https://doi.org/10.1016/j.rmed.2012.06.018.

PMID
22801586
Full Text

Brennan, J Matthew, David Dai, Manesh R. Patel, Sunil V. Rao, Ehrin J. Armstrong, John C. Messenger, Jeptha P. Curtis, et al. “Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008..” J Am Coll Cardiol 59, no. 7 (February 14, 2012): 648–54. https://doi.org/10.1016/j.jacc.2011.10.883.

PMID
22322080
Full Text

Eisenstein, Eric L., David F. Kong, Patricia A. Cowper, Jay P. Bae, Krishnan Ramaswamy, and Kevin J. Anstrom. “Nonfatal myocardial infarction and long-term outcomes in coronary artery disease..” Am Heart J 163, no. 1 (January 2012): 95–103. https://doi.org/10.1016/j.ahj.2011.09.024.

PMID
22172442
Full Text

Brennan, J Matthew, Eric D. Peterson, John C. Messenger, John S. Rumsfeld, William S. Weintraub, Kevin J. Anstrom, Eric L. Eisenstein, et al. “Linking the National Cardiovascular Data Registry CathPCI Registry with Medicare claims data: validation of a longitudinal cohort of elderly patients undergoing cardiac catheterization..” Circ Cardiovasc Qual Outcomes 5, no. 1 (January 2012): 134–40. https://doi.org/10.1161/CIRCOUTCOMES.111.963280.

PMID
22253370
Full Text

Eisenstein, Eric L., Kevin J. Anstrom, Rex Edwards, Janese M. Willis, Jessica Simo, and David F. Lobach. “Population-based clinical decision support: a clinical and economic evaluation..” Stud Health Technol Inform 180 (2012): 343–47.

PMID
22874209
Scholars@Duke

Eisenstein, Eric L., Lawrence W. Diener, Meredith Nahm, and Kevin P. Weinfurt. “Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the design and operation of multi-center clinical trials: a qualitative research study..” J Med Syst 35, no. 6 (December 2011): 1521–30. https://doi.org/10.1007/s10916-010-9429-8.

PMID
20703765
Full Text

Tsai, Thomas T., John C. Messenger, J Matthew Brennan, Uptal D. Patel, David Dai, Robert N. Piana, Kevin J. Anstrom, et al. “Safety and efficacy of drug-eluting stents in older patients with chronic kidney disease: a report from the linked CathPCI Registry-CMS claims database..” J Am Coll Cardiol 58, no. 18 (October 25, 2011): 1859–69. https://doi.org/10.1016/j.jacc.2011.06.056.

PMID
22018296
Full Text

Pages