Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Community and Family Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Willis, Janese M., Rex Edwards, Kevin J. Anstrom, Fred S. Johnson, Guilherme Del Fiol, Kensaku Kawamoto, Nancy M Allen Lapointe, Eric L. Eisenstein, and David F. Lobach. “Decision support for evidence-based pharmacotherapy detects adherence problems but does not impact medication use..” Studies in Health Technology and Informatics 183 (January 2013): 116–25.

PMID
23388267
Scholars@Duke

Willis JM, S. J., R. Edwards, K. J. Anstrom, F. S. Johnson, G. Del Fiol, K. Kawamoto, N. M. Allen lapointe, E. L. Eisenstein, and D. F. Lobach. “Decision Support for Evidence-Based Pharmacotherapy Detects Adherence Problems but Does Not Impact Medication Use.” In Enabling Health and Healthcare Through ICT, edited by Karen L. Courtney, Omid Shabestari, and Alexander Kuo, 183:116–25. IOS Press, 2013.

Scholars@Duke

Eisenstein, E. L., L. Davidson-Ray, R. Edwards, K. J. Anstrom, and K. Ouriel. “Economic analysis of endovascular repair versus surveillance for patients with small abdominal aortic aneurysms.” Journal of Vascular Surgery 58, no. 2 (2013): 302–10. https://doi.org/10.1016/j.jvs.2013.01.038.

Full Text

Eisenstein, Eric L., Linda Davidson-Ray, Rex Edwards, Kevin J. Anstrom, Patricia A. Cowper, Daniel B. Mark, and Thomas R. Aversano. “Economic Outcomes of Percutaneous Coronary Intervention Performed at Sites With and Without On-Site Cardiac Surgery.” In Circulation, 126:2779–2779. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Hillegass, William B., Manesh R. Patel, Lloyd W. Klein, Hitinder S. Gurm, J Matthew Brennan, Kevin J. Anstrom, David Dai, et al. “Long-term outcomes of older diabetic patients after percutaneous coronary stenting in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008..” Journal of the American College of Cardiology 60, no. 22 (December 2012): 2280–89. https://doi.org/10.1016/j.jacc.2012.08.993.

PMID
23194940
Full Text

Eisenstein, Eric L., Daniel Wojdyla, Kevin J. Anstrom, J Matthew Brennan, Robert M. Califf, Eric D. Peterson, and Pamela S. Douglas. “Evaluating the impact of public health notification: Duke clopidogrel experience..” Circulation. Cardiovascular Quality and Outcomes 5, no. 6 (November 2012): 767–74. https://doi.org/10.1161/circoutcomes.111.963330.

PMID
23093562
Full Text

Swigris, Jeffrey J., Meilan Han, Rekha Vij, Imre Noth, Eric L. Eisenstein, Kevin J. Anstrom, Kevin K. Brown, and Diane Fairclough. “The UCSD shortness of breath questionnaire has longitudinal construct validity in idiopathic pulmonary fibrosis..” Respiratory Medicine 106, no. 10 (October 2012): 1447–55. https://doi.org/10.1016/j.rmed.2012.06.018.

PMID
22801586
Full Text

Brennan, J Matthew, David Dai, Manesh R. Patel, Sunil V. Rao, Ehrin J. Armstrong, John C. Messenger, Jeptha P. Curtis, et al. “Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008..” Journal of the American College of Cardiology 59, no. 7 (February 2012): 648–54. https://doi.org/10.1016/j.jacc.2011.10.883.

PMID
22322080
Full Text

Brennan, J Matthew, Eric D. Peterson, John C. Messenger, John S. Rumsfeld, William S. Weintraub, Kevin J. Anstrom, Eric L. Eisenstein, et al. “Linking the National Cardiovascular Data Registry CathPCI Registry with Medicare claims data: validation of a longitudinal cohort of elderly patients undergoing cardiac catheterization..” Circ Cardiovasc Qual Outcomes 5, no. 1 (January 2012): 134–40. https://doi.org/10.1161/CIRCOUTCOMES.111.963280.

PMID
22253370
Full Text

Eisenstein, Eric L., Kevin J. Anstrom, Rex Edwards, Janese M. Willis, Jessica Simo, and David F. Lobach. “Population-based clinical decision support: a clinical and economic evaluation..” Studies in Health Technology and Informatics 180 (January 2012): 343–47.

PMID
22874209
Scholars@Duke

Pages