Erik Magnus Ohman, MBBS

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7403 Duke North, Durham, NC 27710
Phone (919) 681-2069
Email address ohman001@mc.duke.edu

The main focus of my research is in the management of acute myocardial infarction. My focus has revolved around the use of interventional procedures such as balloon angioplasty, intra-aortic balloon pumping and other support devices for the management of patients with acute myocardial infarction. Through participating and designing a number of randomized trials, we have helped crystallize the management to sustain patency of the infarct-related coronary artery in acute myocardial infarction. Furthermore, I have conducted several large multi-center clinical trials on the use of intra-aortic counterpulsation and angioplasty to better understand the pathophysiology of interventional procedures. Another major focus has been in the area of risk stratification in acute myocardial infarction. Early observations done abroad have led me to use new cardiac markers to identify high and low risk patients. Further research in this area will integrate early and rapid triage along with monitoring of the effect of thrombolysis after reperfusion in patients. A patent in the latter category has already been issued. My continued focus in the performance of multi-center international clinical trials has allowed us to explore different treatment strategies for the management of acute myocardial infarction from an international prospective. We have also collected angioplasty data on nearly 6,000 patients from around North America to further explore international differences in the management of patients using percutaneous interventions.

In Their Words

Education and Training

  • M.B.B.S., Royal College of Surgeons (Ireland), 1981

Publications

Chan, MY, Neely, ML, Roe, MT, Goodman, SG, Erlinge, D, Cornel, JH, Winters, KJ, Jakubowski, JA, Zhou, C, Fox, KAA, Armstrong, PW, White, HD, Prabhakaran, D, Ohman, EM, Huber, K, and TRILOGY ACS Investigators, . "Temporal Biomarker Profiling Reveals Longitudinal Changes in Risk of Death or Myocardial Infarction in Non-ST-Segment Elevation Acute Coronary Syndrome." Clinical Chemistry 63, no. 7 (July 2017): 1214-1226.

PMID
28515099
Full Text

Brener, SJ, Mehran, R, Dangas, GD, Ohman, EM, Witzenbichler, B, Zhang, Y, Parvataneni, R, and Stone, GW. "Relation of Baseline Hemoglobin Levels and Adverse Events in Patients With Acute Coronary Syndromes (from the Acute Catheterization and Urgent Intervention Triage strategY and Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction Trials)." The American journal of cardiology 119, no. 11 (June 2017): 1710-1716.

PMID
28388994
Full Text

Wang, A, Kwee, LC, Grass, E, Neely, ML, Gregory, SG, Fox, KAA, Armstrong, PW, White, HD, Ohman, EM, Roe, MT, Shah, SH, and Chan, MY. "Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome." Atherosclerosis 261 (June 2017): 19-25.

PMID
28437675
Full Text

Ohman, EM, Roe, MT, Steg, PG, James, SK, Povsic, TJ, White, J, Rockhold, F, Plotnikov, A, Mundl, H, Strony, J, Sun, X, Husted, S, Tendera, M, Montalescot, G, Bahit, MC, Ardissino, D, Bueno, H, Claeys, MJ, Nicolau, JC, Cornel, JH, Goto, S, Kiss, RG, Güray, Ü, Park, D-W, Bode, C, Welsh, RC, and Gibson, CM. "Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial." Lancet (London, England) 389, no. 10081 (May 2017): 1799-1808.

PMID
28325638
Full Text

Basir, MB, Schreiber, TL, Grines, CL, Dixon, SR, Moses, JW, Maini, BS, Khandelwal, AK, Ohman, EM, and O'Neill, WW. "Effect of Early Initiation of Mechanical Circulatory Support on Survival in Cardiogenic Shock." The American Journal of Cardiology 119, no. 6 (March 2017): 845-851.

PMID
28040188
Full Text

Lau, ES, Braunwald, E, Murphy, SA, Wiviott, SD, Bonaca, MP, Husted, S, James, SK, Wallentin, L, Clemmensen, P, Roe, MT, Ohman, EM, Harrington, RA, Mega, JL, Bhatt, DL, Sabatine, MS, and O'Donoghue, ML. "Potent P2Y12 Inhibitors in Men Versus Women: A Collaborative Meta-Analysis of Randomized Trials." Journal of the American College of Cardiology 69, no. 12 (March 2017): 1549-1559.

PMID
28335837
Full Text

Welsh, RC, Roe, MT, Steg, PG, James, S, Povsic, TJ, Bode, C, Gibson, CM, and Ohman, EM. "Corrigendum to "A critical reappraisal of aspirin for secondary prevention in patients with ischemic heart disease" [Am Heart J 181 (2016) 92-100]." American Heart Journal 184 (February 2017): 156-null.

PMID
28224931
Full Text

Ohman, EM. "Redefining the Gold Standard of Myocardial Infarction Using Troponin T." Clinical chemistry 63, no. 1 (January 2017): 429-430. (Review)

PMID
27811205
Full Text

Schoos, MM, Mehran, R, Dangas, GD, Yu, J, Baber, U, Clemmensen, P, Feit, F, Gersh, BJ, Guagliumi, G, Ohman, EM, Pocock, SJ, Witzenbichler, B, and Stone, GW. "Gender Differences in Associations Between Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention and Adverse Outcomes." The American Journal of Cardiology 118, no. 11 (December 2016): 1661-1668.

PMID
27836132
Full Text

Baber, U, Dangas, G, Cohen, DJ, Gibson, CM, Mehta, SR, Angiolillo, DJ, Pocock, SJ, Krucoff, MW, Kastrati, A, Ohman, EM, Steg, PG, Badimon, J, Zafar, MU, Chandrasekhar, J, Sartori, S, Aquino, M, and Mehran, R. "Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: Rationale and design of the TWILIGHT study." American Heart Journal 182 (December 2016): 125-134.

PMID
27914492
Full Text

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