Erik Magnus Ohman, MBBS

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7403 Duke North, Durham, NC 27710
Phone (919) 681-2069
Email address ohman001@mc.duke.edu

The main focus of my research is in the management of acute myocardial infarction. My focus has revolved around the use of interventional procedures such as balloon angioplasty, intra-aortic balloon pumping and other support devices for the management of patients with acute myocardial infarction. Through participating and designing a number of randomized trials, we have helped crystallize the management to sustain patency of the infarct-related coronary artery in acute myocardial infarction. Furthermore, I have conducted several large multi-center clinical trials on the use of intra-aortic counterpulsation and angioplasty to better understand the pathophysiology of interventional procedures. Another major focus has been in the area of risk stratification in acute myocardial infarction. Early observations done abroad have led me to use new cardiac markers to identify high and low risk patients. Further research in this area will integrate early and rapid triage along with monitoring of the effect of thrombolysis after reperfusion in patients. A patent in the latter category has already been issued. My continued focus in the performance of multi-center international clinical trials has allowed us to explore different treatment strategies for the management of acute myocardial infarction from an international prospective. We have also collected angioplasty data on nearly 6,000 patients from around North America to further explore international differences in the management of patients using percutaneous interventions.

In Their Words

Education and Training

  • M.B.B.S., Royal College of Surgeons (Ireland), 1981

Publications

Clemmensen, P, Roe, MT, Hochman, JS, Cyr, DD, Neely, ML, McGuire, DK, Cornel, JH, Huber, K, Zamoryakhin, D, White, HD, Armstrong, PW, Fox, KAA, Prabhakaran, D, Ohman, EM, and TRILOGY ACS Investigators, . "Long-term outcomes for women versus men with unstable angina/non-ST-segment elevation myocardial infarction managed medically without revascularization: insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes trial." American heart journal 170, no. 4 (October 2015): 695-705.e5.

PMID
26386793
Full Text

Nicolau, JC, Bhatt, DL, Roe, MT, Lokhnygina, Y, Neely, B, Corbalán, R, Leiva-Pons, JL, Martinez, F, Goodman, SG, Winters, KJ, Verheugt, FWA, Armstrong, PW, White, HD, Fox, KAA, Prabhakaran, D, Ohman, EM, and TRILOGY ACS investigators, . "Concomitant proton-pump inhibitor use, platelet activity, and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel and managed without revascularization: insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes trial." American Heart Journal 170, no. 4 (October 2015): 683-694.e3.

PMID
26386792
Full Text

Mennuni, MG, Dangas, GD, Mehran, R, Ben-Gal, Y, Xu, K, Généreux, P, Brener, SJ, Feit, F, Lincoff, AM, Ohman, EM, Hamon, M, and Stone, GW. "Coronary Artery Bypass Surgery Compared With Percutaneous Coronary Intervention for Proximal Left Anterior Descending Artery Treatment in Patients With Acute Coronary Syndrome: Analysis From the ACUITY Trial." The Journal of invasive cardiology 27, no. 10 (October 2015): 468-473.

PMID
26121708
Scholars@Duke

Cavender, MA, Steg, PG, Smith, SC, Eagle, K, Ohman, EM, Goto, S, Kuder, J, Im, K, Wilson, PWF, Bhatt, DL, and REACH Registry Investigators, . "Impact of Diabetes Mellitus on Hospitalization for Heart Failure, Cardiovascular Events, and Death: Outcomes at 4 Years From the Reduction of Atherothrombosis for Continued Health (REACH) Registry." Circulation 132, no. 10 (September 2015): 923-931.

PMID
26152709
Full Text

Daubert, MA, Massaro, J, Liao, L, Pershad, A, Mulukutla, S, Magnus Ohman, E, Popma, J, O'Neill, WW, and Douglas, PS. "High-risk percutaneous coronary intervention is associated with reverse left ventricular remodeling and improved outcomes in patients with coronary artery disease and reduced ejection fraction." American heart journal 170, no. 3 (September 2015): 550-558.

PMID
26385039
Full Text

Patel, MR, and Ohman, EM. "The Early Invasive Strategy in Acute Coronary Syndromes: Should the Guideline Recommendations Be Revisited?." Journal of the American College of Cardiology 66, no. 5 (August 2015): 521-523.

PMID
26227189
Full Text

Husted, SE, and Ohman, EM. "Pharmacological and emerging therapies in the treatment of chronic angina." Lancet (London, England) 386, no. 9994 (August 2015): 691-701. (Review)

PMID
26334161
Full Text

Kragholm, K, Halim, SA, Yang, Q, Schulte, PJ, Hochman, JS, Melloni, C, Mahaffey, KW, Moliterno, DJ, Harrington, RA, White, HD, Armstrong, PW, Ohman, EM, Van de Werf, F, Tricoci, P, Alexander, JH, Giugliano, RP, and Newby, LK. "Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years." Circulation. Cardiovascular Quality and Outcomes 8, no. 4 (July 7, 2015): 357-367.

PMID
26152683
Full Text

Ben-Gal, Y, Mohr, R, Feit, F, Ohman, EM, Kirtane, A, Xu, K, Mehran, R, and Stone, GW. "Surgical versus percutaneous coronary revascularization for multivessel disease in diabetic patients with non-ST-segment-elevation acute coronary syndrome: analysis from the Acute Catheterization and Early Intervention Triage Strategy trial." Circulation. Cardiovascular interventions 8, no. 6 (June 2015).

PMID
26019142
Full Text

Thiele, H, Ohman, EM, Desch, S, Eitel, I, and de Waha, S. "Management of cardiogenic shock." European Heart Journal 36, no. 20 (May 2015): 1223-1230. (Review)

PMID
25732762
Full Text

Pages