Erik Magnus Ohman, MBBS

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7403 Duke North, Durham, NC 27710
Phone (919) 681-2069
Email address ohman001@mc.duke.edu

The main focus of my research is in the management of acute myocardial infarction. My focus has revolved around the use of interventional procedures such as balloon angioplasty, intra-aortic balloon pumping and other support devices for the management of patients with acute myocardial infarction. Through participating and designing a number of randomized trials, we have helped crystallize the management to sustain patency of the infarct-related coronary artery in acute myocardial infarction. Furthermore, I have conducted several large multi-center clinical trials on the use of intra-aortic counterpulsation and angioplasty to better understand the pathophysiology of interventional procedures. Another major focus has been in the area of risk stratification in acute myocardial infarction. Early observations done abroad have led me to use new cardiac markers to identify high and low risk patients. Further research in this area will integrate early and rapid triage along with monitoring of the effect of thrombolysis after reperfusion in patients. A patent in the latter category has already been issued. My continued focus in the performance of multi-center international clinical trials has allowed us to explore different treatment strategies for the management of acute myocardial infarction from an international prospective. We have also collected angioplasty data on nearly 6,000 patients from around North America to further explore international differences in the management of patients using percutaneous interventions.

In Their Words

Education and Training

  • M.B.B.S., Royal College of Surgeons (Ireland), 1981

Publications

Henriques, JPS, Ouweneel, DM, Naidu, SS, Palacios, IF, Popma, J, Ohman, EM, and O'Neill, WW. "Evaluating the learning curve in the prospective Randomized Clinical Trial of hemodynamic support with Impella 2.5 versus Intra-Aortic Balloon Pump in patients undergoing high-risk percutaneous coronary intervention: a prespecified subanalysis of the PROTECT II study." American heart journal 167, no. 4 (April 2014): 472-479.e5.

PMID
24655695
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Lansky, AJ, Ng, VG, Meller, S, Xu, K, Fahy, M, Feit, F, Ohman, EM, White, HD, Mehran, R, Bertrand, ME, Desmet, W, Hamon, M, and Stone, GW. "Impact of nonculprit vessel myocardial perfusion on outcomes of patients undergoing percutaneous coronary intervention for acute coronary syndromes: analysis from the ACUITY trial (Acute Catheterization and Urgent Intervention Triage Strategy)." JACC. Cardiovascular interventions 7, no. 3 (March 2014): 266-275.

PMID
24650400
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O'Neill, WW, Schreiber, T, Wohns, DHW, Rihal, C, Naidu, SS, Civitello, AB, Dixon, SR, Massaro, JM, Maini, B, and Ohman, EM. "The current use of Impella 2.5 in acute myocardial infarction complicated by cardiogenic shock: results from the USpella Registry." Journal of interventional cardiology 27, no. 1 (February 2014): 1-11.

PMID
24329756
Full Text

van Diepen, S, Reynolds, HR, Stebbins, A, Lopes, RD, Džavík, V, Ruzyllo, W, Geppert, A, Widimsky, P, Ohman, EM, Parrillo, JE, Dauerman, HL, Baran, DA, Hochman, JS, and Alexander, JH. "Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock." Crit Care Med 42, no. 2 (February 2014): 281-288.

PMID
23982033
Full Text

Dangas, GD, Kini, AS, Sharma, SK, Henriques, JPS, Claessen, BE, Dixon, SR, Massaro, JM, Palacios, I, Popma, JJ, Ohman, EM, Stone, GW, and O'Neill, WW. "Impact of hemodynamic support with impella 2.5 versus intra-aortic balloon pump on prognostically important clinical outcomes in patients undergoing high-risk percutaneous coronary intervention (from the PROTECT II randomized trial)." American Journal of Cardiology 113, no. 2 (January 15, 2014): 222-228.

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Huber, K, Bates, ER, Valgimigli, M, Wallentin, L, Kristensen, SD, Anderson, JL, Lopez Sendon, JL, Tubaro, M, Granger, CB, Bode, C, Ohman, EM, and Steg, PG. "Antiplatelet and anticoagulation agents in acute coronary syndromes: What is the current status and what does the future hold?." American Heart Journal 168, no. 5 (January 1, 2014): 611-621.

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Diepen, SV, Reynolds, HR, Stebbins, A, Lopes, RD, Džavík, V, Ruzyllo, W, Geppert, A, Widimsky, P, Ohman, EM, Parrillo, JE, Dauerman, HL, Baran, DA, Hochman, JS, and Alexander, JH. "Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock." Critical Care Medicine 42, no. 2 (2014): 281-288.

Full Text

Ruff, CT, Bhatt, DL, Steg, PG, Gersh, BJ, Alberts, MJ, Hoffman, EB, Ohman, EM, Eagle, KA, Lip, GYH, Goto, S, and REACH Registry Investigators, . "Long-term cardiovascular outcomes in patients with atrial fibrillation and atherothrombosis in the REACH Registry." Int J Cardiol 170, no. 3 (January 1, 2014): 413-418.

PMID
24321327
Full Text

Ruff, CT, Bhatt, DL, Steg, PG, Gersh, BJ, Alberts, MJ, Hoffman, EB, Ohman, EM, Eagle, KA, Lip, GYH, and Goto, S. "Long-term cardiovascular outcomes in patients with atrial fibrillation and atherothrombosis in the REACH Registry." International Journal of Cardiology 170, no. 3 (January 1, 2014): 413-418.

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Kohli, P, Steg, PG, Cannon, CP, Smith, SC, Eagle, KA, Ohman, EM, Alberts, MJ, Hoffman, E, Guo, J, Simon, T, Sorbets, E, Goto, S, and Bhatt, DL. "NSAID use and association with cardiovascular outcomes in outpatients with stable atherothrombotic disease." American Journal of Medicine 127, no. 1 (January 1, 2014).

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