Erik Magnus Ohman, MBBS

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7403 Duke North, Durham, NC 27710
Phone (919) 681-2069
Email address ohman001@mc.duke.edu

The main focus of my research is in the management of acute myocardial infarction. My focus has revolved around the use of interventional procedures such as balloon angioplasty, intra-aortic balloon pumping and other support devices for the management of patients with acute myocardial infarction. Through participating and designing a number of randomized trials, we have helped crystallize the management to sustain patency of the infarct-related coronary artery in acute myocardial infarction. Furthermore, I have conducted several large multi-center clinical trials on the use of intra-aortic counterpulsation and angioplasty to better understand the pathophysiology of interventional procedures. Another major focus has been in the area of risk stratification in acute myocardial infarction. Early observations done abroad have led me to use new cardiac markers to identify high and low risk patients. Further research in this area will integrate early and rapid triage along with monitoring of the effect of thrombolysis after reperfusion in patients. A patent in the latter category has already been issued. My continued focus in the performance of multi-center international clinical trials has allowed us to explore different treatment strategies for the management of acute myocardial infarction from an international prospective. We have also collected angioplasty data on nearly 6,000 patients from around North America to further explore international differences in the management of patients using percutaneous interventions.

In Their Words

Education and Training

  • M.B.B.S., Royal College of Surgeons (Ireland), 1981

Publications

Diepen, SV, Reynolds, HR, Stebbins, A, Lopes, RD, Džavík, V, Ruzyllo, W, Geppert, A, Widimsky, P, Ohman, EM, Parrillo, JE, Dauerman, HL, Baran, DA, Hochman, JS, and Alexander, JH. "Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock." Critical Care Medicine 42, no. 2 (2014): 281-288.

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Ruff, CT, Bhatt, DL, Steg, PG, Gersh, BJ, Alberts, MJ, Hoffman, EB, Ohman, EM, Eagle, KA, Lip, GYH, Goto, S, and REACH Registry Investigators, . "Long-term cardiovascular outcomes in patients with atrial fibrillation and atherothrombosis in the REACH Registry." Int J Cardiol 170, no. 3 (January 1, 2014): 413-418.

PMID
24321327
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Ruff, CT, Bhatt, DL, Steg, PG, Gersh, BJ, Alberts, MJ, Hoffman, EB, Ohman, EM, Eagle, KA, Lip, GYH, and Goto, S. "Long-term cardiovascular outcomes in patients with atrial fibrillation and atherothrombosis in the REACH Registry." International Journal of Cardiology 170, no. 3 (January 1, 2014): 413-418.

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Rodés-Cabau, J, Dauerman, HL, Cohen, MG, Mehran, R, Small, EM, Smyth, SS, Costa, MA, Mega, JL, O'Donoghue, ML, Ohman, EM, and Becker, RC. "Antithrombotic treatment in transcatheter aortic valve implantation: insights for cerebrovascular and bleeding events." J Am Coll Cardiol 62, no. 25 (December 24, 2013): 2349-2359. (Review)

PMID
23583252
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Weisz, G, Farzaneh-Far, R, Ben-Yehuda, O, Debruyne, B, Montalescot, G, Lerman, A, Mahmud, E, Alexander, KP, Ohman, EM, White, HD, Olmsted, A, Walker, GA, and Stone, GW. "Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: Design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial." American Heart Journal 166, no. 6 (December 1, 2013).

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Rodriguez, F, Cannon, CP, Steg, PG, Kumbhani, DJ, Goto, S, Smith, SC, Eagle, KA, Ohman, EM, Umez-Eronini, AA, Hoffman, E, and Bhatt, DL. "Predictors of long-term adherence to evidence-based cardiovascular disease medications in outpatients with stable atherothrombotic disease: Findings from the REACH registry." Clinical Cardiology 36, no. 12 (December 1, 2013): 721-727.

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Anderson, ML, Peterson, ED, Peng, SA, Wang, TY, Ohman, EM, Bhatt, DL, Saucedo, JF, and Roe, MT. "Differences in the profile, treatment, and prognosis of patients with cardiogenic shock by myocardial infarction classification: A report from NCDR." Circ Cardiovasc Qual Outcomes 6, no. 6 (November 2013): 708-715.

PMID
24221834
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Lopes, RD, White, JA, Atar, D, Keltai, M, Kleiman, NS, White, HD, Widimsky, P, Zeymer, U, Giugliano, RP, Tricoci, P, Braunwald, E, Bode, C, Ohman, EM, Armstrong, PW, and Newby, LK. "Incidence, treatment, and outcomes of atrial fibrillation complicating non-ST-segment elevation acute coronary syndromes." Int J Cardiol 168, no. 3 (October 3, 2013): 2510-2517.

PMID
23578889
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Vemulapalli, S, Zhou, Y, Gutberlet, M, Kumar, AS, Mills, JS, Blaxill, J, Smalling, R, Ohman, EM, and Patel, MR. "Importance of total ischemic time and preprocedural infarct-related artery blood flow in predicting infarct size in patients with anterior wall myocardial infarction (from the CRISP-AMI Trial)." Am J Cardiol 112, no. 7 (October 1, 2013): 911-917.

PMID
23768458
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Roe, MT, Goodman, SG, Ohman, EM, Stevens, SR, Hochman, JS, Gottlieb, S, Martinez, F, Dalby, AJ, Boden, WE, White, HD, Prabhakaran, D, Winters, KJ, Aylward, PE, Bassand, J-P, McGuire, DK, Ardissino, D, Fox, KAA, and Armstrong, PW. "Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel." Circulation 128, no. 8 (August 20, 2013): 823-833.

PMID
23852610
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