Feng Gao, MD

Professor of Medicine
Member of the Duke Human Vaccine Institute
Campus mail 244 Sands Bldg, Box 102359, Durham, NC 27710
Phone (919) 668-6433
Email address feng.gao@duke.edu

Dr. Feng Gao is Professor of Medicine at Duke University. The Gao laboratory has a long-standing interest in elucidating the origins and evolution of human and simian inmmunodeficiency viruses (HIV and SIV), and in studying HIV/SIV gene function and pathogenic mechanisms from the evolutionary perspective. These studies have led to new strategies to better understand HIV origins,  biology, pathogenesis and drug resistance, and to design new AIDS vaccines.

Education and Training

  • M.D., Harbin Medical University (China), 1984

Publications

Liu, Michael K. P., Natalie Hawkins, Adam J. Ritchie, Vitaly V. Ganusov, Victoria Whale, Simon Brackenridge, Hui Li, et al. “Vertical T cell immunodominance and epitope entropy determine HIV-1 escape..” J Clin Invest 123, no. 1 (January 2013): 380–93. https://doi.org/10.1172/JCI65330.

PMID
23221345
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Ma, Jie, Yingchun Zhang, Xinyue Chen, Yi Jin, Dexi Chen, Yun Wu, Jing Cui, et al. “Association of preexisting drug-resistance mutations and treatment failure in hepatitis B patients..” Plos One 8, no. 7 (2013). https://doi.org/10.1371/journal.pone.0067606.

PMID
23935839
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Song, Hongshuo, Jeffrey W. Pavlicek, Fangping Cai, Tanmoy Bhattacharya, Hui Li, Shilpa S. Iyer, Katharine J. Bar, et al. “Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome..” Retrovirology 9 (October 30, 2012). https://doi.org/10.1186/1742-4690-9-89.

PMID
23110705
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Song, Hongshuo, Furong Ren, Jin Li, Shuang Shi, Ling Yan, Feng Gao, Kui Li, and Hui Zhuang. “A laboratory-adapted HCV JFH-1 strain is sensitive to neutralization and can gradually escape under the selection pressure of neutralizing human plasma..” Virus Res 169, no. 1 (October 2012): 154–61. https://doi.org/10.1016/j.virusres.2012.07.022.

PMID
22846920
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Fouda, G. G., T. Mahlokozera, K. Rizzolo, J. Salazar-Gonzalez, M. Salazar, G. Learn, S. Barotra, et al. “Postnatally-transmitted HIV-1 variants are efficient at dendritic cell trans-infection and sensitive to autologous and heterologous neutralization.” Retrovirology 9, no. S2 (September 2012). https://doi.org/10.1186/1742-4690-9-s2-p148.

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Montefiori, David, Haili Tang, S. Gnanakaran, Feng Gao, Mattia Bonsignori, James Binley, Georgia Tomaras, et al. “116 Autologous and Heterologous Neutralizing Antibody Responses in HIV-1 Infection.” Jaids Journal of Acquired Immune Deficiency Syndromes 59 (April 2012): 47–47. https://doi.org/10.1097/01.qai.0000413735.52728.f8.

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Bar, Katharine J., Chun-yen Tsao, Shilpa S. Iyer, Julie M. Decker, Yongping Yang, Mattia Bonsignori, Xi Chen, et al. “Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape..” Plos Pathog 8, no. 5 (2012). https://doi.org/10.1371/journal.ppat.1002721.

PMID
22693447
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Parrish, Nicholas F., Craig B. Wilen, Lauren B. Banks, Shilpa S. Iyer, Jennifer M. Pfaff, Jesus F. Salazar-Gonzalez, Maria G. Salazar, et al. “Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7..” Plos Pathog 8, no. 5 (2012). https://doi.org/10.1371/journal.ppat.1002686.

PMID
22693444
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Tomaras, Georgia D., James M. Binley, Elin S. Gray, Emma T. Crooks, Keiko Osawa, Penny L. Moore, Nancy Tumba, et al. “Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals..” J Virol 85, no. 21 (November 2011): 11502–19. https://doi.org/10.1128/JVI.05363-11.

PMID
21849452
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Liu, Pinghuang, R Glenn Overman, Nicole L. Yates, S Munir Alam, Nathan Vandergrift, Yue Chen, Frederik Graw, et al. “Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection..” J Virol 85, no. 21 (November 2011): 11196–207. https://doi.org/10.1128/JVI.05601-11.

PMID
21865397
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Pages