Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Pagano, PJ, Griendling, KK, Miller, FJ, Laurindo, FRM, and Touyz, RM. "Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout." Antioxidants & Redox Signaling 23, no. 15 (November 2015): 1246-1247. (Letter)

PMID
26054248
Full Text

Thiel, WH, Esposito, CL, Dickey, DD, Dassie, JP, Long, ME, Adam, J, Streeter, J, Schickling, B, Takapoo, M, Flenker, KS, Klesney-Tait, J, de Franciscis, V, Miller, FJ, and Giangrande, PH. "61. Vascular Smooth Muscle Cell RNA Aptamers for the Treatment of Cardiovascular Disease." May 2015.

Full Text

Leisegang, MS, Fork, C, Miller, MJ, Ponomareva, Y, Uchida, S, Jr, MFJ, and Brandes, RP. "The long non-coding RNA Mantis is highly expressed during vascular regeneration and essential for the VEGF-A-induced angiogenic function." ACTA PHYSIOLOGICA 213 (March 2015): 148-149.

Scholars@Duke

Thiel, WH, Thiel, KW, Flenker, KS, Bair, T, Dupuy, AJ, McNamara, JO, Miller, FJ, and Giangrande, PH. "Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells." Methods in Molecular Biology (Clifton, N.J.) 1218 (January 2015): 187-199.

PMID
25319652
Full Text

Streeter, J, Schickling, BM, Jiang, S, Stanic, B, Thiel, WH, Gakhar, L, Houtman, JCD, and Miller, FJ. "Phosphorylation of Nox1 regulates association with NoxA1 activation domain." Circulation Research 115, no. 11 (November 2014): 911-918.

PMID
25228390
Full Text

Vikram, A, Kim, Y-R, Kumar, S, Naqvi, A, Hoffman, TA, Kumar, A, Miller, FJ, Kim, C-S, and Irani, K. "Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species." Arteriosclerosis, Thrombosis, and Vascular Biology 34, no. 10 (October 2014): 2301-2309.

PMID
25147340
Full Text

Steyers, CM, and Miller, FJ. "Endothelial dysfunction in chronic inflammatory diseases." International Journal of Molecular Sciences 15, no. 7 (June 25, 2014): 11324-11349. (Review)

PMID
24968272
Full Text

Thiel, WH, Dickey, DD, Streeter, J, Brandon, S, Dassie, JP, Takapoo, M, Liu, X, Jr, MFJ, and Giangrande, PH. "Cell-Targeted RNA-Based Therapies for Cardiovascular Disease." May 2014.

Scholars@Duke

Csányi, G, and Miller, FJ. "Oxidative stress in cardiovascular disease." International Journal of Molecular Sciences 15, no. 4 (April 9, 2014): 6002-6008.

PMID
24722571
Full Text

Jiang, S, Streeter, J, Schickling, BM, Zimmerman, K, Weiss, RM, and Miller, FJ. "Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning." Cardiovascular research 102, no. 1 (April 2014): 79-87.

PMID
24501329
Full Text

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