Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Sobhakumari, A, Schickling, BM, Love-Homan, L, Raeburn, A, Fletcher, EVM, Case, AJ, Domann, FE, Miller, FJ, and Simons, AL. "NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells." Toxicology and applied pharmacology 272, no. 3 (November 2013): 736-745.

PMID
23917044
Full Text

Streeter, J, Schickling, B, and Miller, FJ. "Nox1 Endocytosis and Activation Are Regulated by Intracellular Hydrophobic Motifs." Free Radical Biology and Medicine 65 (November 2013): S83-S83.

Full Text

Makki, N, Thiel, KW, and Miller, FJ. "The epidermal growth factor receptor and its ligands in cardiovascular disease." International journal of molecular sciences 14, no. 10 (October 15, 2013): 20597-20613. (Review)

PMID
24132149
Full Text

Kinkade, K, Streeter, J, and Miller, FJ. "Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis." International journal of molecular sciences 14, no. 8 (August 19, 2013): 17017-17028.

PMID
23965970
Full Text

Sanders, PN, Koval, OM, Jaffer, OA, Prasad, AM, Businga, TR, Scott, JA, Hayden, PJ, Luczak, ED, Dickey, DD, Allamargot, C, Olivier, AK, Meyerholz, DK, Robison, AJ, Winder, DG, Blackwell, TS, Dworski, R, Sammut, D, Wagner, BA, Buettner, GR, Pope, RM, Miller, FJ, Dibbern, ME, Haitchi, HM, Mohler, PJ, Howarth, PH, Zabner, J, Kline, JN, Grumbach, IM, and Anderson, ME. "CaMKII is essential for the proasthmatic effects of oxidation." Science Translational Medicine 5, no. 195 (July 2013): 195ra97-null.

PMID
23884469
Full Text

Streeter, J, Thiel, W, Brieger, K, and Miller, FJ. "Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease." Cardiovascular Therapeutics 31, no. 3 (June 2013): 125-137. (Review)

PMID
22280098
Full Text

Thiel, WH, Takapoo, M, Jiang, S, Streeter, J, Stanic, B, Liu, X, Jr, MFJ, and Giangrande, PH. "Smooth Muscle Cell Targeted RNA Aptamers for the Treatment of Vascular Disease." June 2013.

Scholars@Duke

Dayal, S, Wilson, KM, Motto, DG, Miller, FJ, Chauhan, AK, and Lentz, SR. "Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis." Circulation 127, no. 12 (March 2013): 1308-1316.

PMID
23426106
Full Text

Foresman, EL, and Miller, FJ. "Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction." Redox biology 1 (January 2013): 292-296.

PMID
24024163
Full Text

Scott, JA, Klutho, PJ, El Accaoui, R, Nguyen, E, Venema, AN, Xie, L, Jiang, S, Dibbern, M, Scroggins, S, Prasad, AM, Luczak, ED, Davis, MK, Li, W, Guan, X, Backs, J, Schlueter, AJ, Weiss, RM, Miller, FJ, Anderson, ME, and Grumbach, IM. "The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling." Plos One 8, no. 8 (January 2013): e71550-null.

PMID
23951185
Full Text

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