Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Whitmore, LC, Hilkin, BM, Goss, KL, Wahle, EM, Colaizy, TT, Boggiatto, PM, Varga, SM, Miller, FJ, and Moreland, JG. "NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults." Journal of innate immunity 5, no. 6 (January 2013): 565-580.

PMID
23635512
Full Text

Jiang, S, Streeter, J, and Miller, F. "Nox1 NADPH Oxidase is Necessary for Late, but not Early, Ischemic Preconditioning against Myocardial Infarction in Mice." November 2012.

Full Text

Streeter, J, Schickling, B, Thiel, W, and Miller, F. "Nox1 Phosphorylation in Cardiovascular Disease." November 2012.

Full Text

Stanic, B, Pandey, D, Fulton, DJ, and Miller, FJ. "Increased epidermal growth factor-like ligands are associated with elevated vascular nicotinamide adenine dinucleotide phosphate oxidase in a primate model of atherosclerosis." Arteriosclerosis, Thrombosis, and Vascular Biology 32, no. 10 (October 2012): 2452-2460.

PMID
22879585
Full Text

Chen, B, Li, Y, Jiang, S, Xie, Y-P, Guo, A, Kutschke, W, Zimmerman, K, Weiss, RM, Miller, FJ, Anderson, ME, and Song, L-S. "β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 26, no. 6 (June 2012): 2531-2537.

PMID
22375019
Full Text

Thiel, WH, Bair, T, Peek, AS, Stanic, B, Takapoo, M, Streeter, J, Behlke, MA, Miller, FJ, and Giangrande, PH. "Aptamer-siRNA Chimera Inhibitors of Intimal Hyperplasia." May 2012.

Scholars@Duke

Jagadeesha, DK, Takapoo, M, Banfi, B, Bhalla, RC, and Miller, FJ. "Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration." Cardiovascular research 93, no. 3 (March 2012): 406-413.

PMID
22102727
Full Text

Thiel, WH, Bair, T, Peek, AS, Liu, X, Dassie, J, Stockdale, KR, Behlke, MA, Miller, FJ, and Giangrande, PH. "Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection." PloS one 7, no. 9 (January 2012): e43836-.

PMID
22962591
Full Text

Xu, S, Shriver, AS, Jagadeesha, DK, Chamseddine, AH, Szőcs, K, Weintraub, NL, Griendling, KK, Bhalla, RC, and Miller, FJ. "Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9." Journal of vascular research 49, no. 3 (January 2012): 242-248.

PMID
22433789
Full Text

Brieger, K, Schiavone, S, Miller, FJ, and Krause, K-H. "Reactive oxygen species: from health to disease." Swiss Medical Weekly 142 (January 2012): w13659-null. (Review)

PMID
22903797
Full Text

Pages