Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Karrowni, W, Dughman, S, Hajj, GP, and Miller, FJ. "Statin therapy reduces growth of abdominal aortic aneurysms." Journal of investigative medicine : the official publication of the American Federation for Clinical Research 59, no. 8 (December 2011): 1239-1243.

PMID
21997311
Full Text

Takapoo, M, Chamseddine, AH, Bhalla, RC, and Miller, FJ. "Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A." Vascular pharmacology 55, no. 5-6 (November 2011): 143-148.

PMID
21782974
Full Text

Zimmerman, MC, Takapoo, M, Jagadeesha, DK, Stanic, B, Banfi, B, Bhalla, RC, and Miller, FJ. "Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells." Hypertension (Dallas, Tex. : 1979) 58, no. 3 (September 2011): 446-453.

PMID
21810651
Full Text

Sheehan, AL, Carrell, S, Johnson, B, Stanic, B, Banfi, B, and Miller, FJ. "Role for Nox1 NADPH oxidase in atherosclerosis." Atherosclerosis 216, no. 2 (June 2011): 321-326.

PMID
21411092
Full Text

Orcutt, KP, Parsons, AD, Sibenaller, ZA, Scarbrough, PM, Zhu, Y, Sobhakumari, A, Wilke, WW, Kalen, AL, Goswami, P, Miller, FJ, Spitz, DR, and Simons, AL. "Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4." Cancer research 71, no. 11 (June 2011): 3932-3940.

PMID
21482679
Full Text

Karrowni, W, and Miller, FJ. "Was the role of statins in slowing the progression of abdominal aortic aneurysms underestimated?." American heart journal 161, no. 5 (May 2011): e29-. (Letter)

PMID
21570503
Full Text

Streeter, J, and Miller, FJ. "Any questions? A concise guide to navigating the Q&A session after a presentation." EMBO reports 12, no. 3 (March 2011): 202-205.

PMID
21368844
Full Text

Chu, X, Filali, M, Stanic, B, Takapoo, M, Sheehan, A, Bhalla, R, Lamb, FS, and Miller, FJ. "A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation." Arteriosclerosis, thrombosis, and vascular biology 31, no. 2 (February 2011): 345-351.

PMID
21071705
Full Text

Dayal, S, Wilson, KM, Jr, MFJ, and Lentz, SR. "Overexpression Of Glutathione Peroxidase-1 Protects Mice From Increased Susceptibility To Experimental Thrombosis With Aging." CIRCULATION 122, no. 21 (November 23, 2010).

Scholars@Duke

Stanic, B, Katsuyama, M, and Miller, FJ. "An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation." Arteriosclerosis, thrombosis, and vascular biology 30, no. 11 (November 2010): 2234-2241.

PMID
20814013
Full Text

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