Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Lentz, SR, Piegors, DJ, Fernandez, JA, Erger, RA, Malinow, MR, Griffin, JH, Haynes, WG, and Heistad, DD. "Effect of hyperhomocysteinemia on protein C activation and activity in vivo." November 16, 2001.

Scholars@Duke

Zhang, Y, Bissing, JW, Xu, L, Ryan, AJ, Martin, SM, Miller, FJ, Kregel, KC, Buettner, GR, and Kerber, RE. "Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model." Journal of the American College of Cardiology 38, no. 2 (August 2001): 546-554.

PMID
11499751
Full Text

Li, WG, Miller, FJ, Zhang, HJ, Spitz, DR, Oberley, LW, and Weintraub, NL. "H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury." The Journal of Biological Chemistry 276, no. 31 (August 2001): 29251-29256.

PMID
11358965
Full Text

Miller, FJ. "Adventitial fibroblasts: backstage journeymen." Arteriosclerosis, thrombosis, and vascular biology 21, no. 5 (May 2001): 722-723.

PMID
11348863
Full Text

Bocker, JM, Miller, FJ, Oltman, CL, Chappell, DA, and Gutterman, DD. "Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta." Japanese Heart Journal 42, no. 3 (May 2001): 317-326.

PMID
11605770
Full Text

Hathaway, CA, Heistad, DD, and Miller, FJ. "Localization of NADPH oxidase in blood vessels from atherosclerotic monkeys." FASEB JOURNAL 15, no. 5 (March 8, 2001): A1128-A1128.

Scholars@Duke

Yao, Y, Lomis, NNT, Scott, SM, Yoon, HC, and Miller, FJ. "Percutaneous sclerotherapy for congenital venous malformations in the extremities." ORTHOPEDICS 24, no. 1 (January 2001): 45-51.

Scholars@Duke

Martin, SM, Zhang, Y, Kregel, KC, Miller, FJ, Buettner, GR, and Kerber, RE. "The nitric oxide synthase inhibitor NG-nitro-L-arginine decreases defibrillation induced free radical generation." FREE RADICAL BIOLOGY AND MEDICINE 31 (2001): S71-S71.

Scholars@Duke

Miller, FJ, Ferley, WM, and Hathaway, CA. "Nitric oxide and peroxynitrite inhibits NADPH oxidase in human vascular smooth muscle cells." FREE RADICAL BIOLOGY AND MEDICINE 31 (2001): S71-S71.

Scholars@Duke

Szscs, K, Lassegue, B, Sorescu, D, Weintraub, NL, Miller, FJ, Lambeth, JD, and Griendling, KK. "Nox-1, a novel gp91phox homologue, is upregulated in restenosis following balloon injury." CIRCULATION 102, no. 18 (October 31, 2000): 303-303.

Scholars@Duke

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