Medical Oncology

Frank Russell Dunphy, MD

Professor of Medicine
Member of Duke Cancer Institute
Campus mail 25178 Morris Bldg, 200 Trent Drive, Durham, NC 27710
Phone (919) 668-6608

Dr. Dunphy's research interests include conducting clinical research by designing therapies using new technologies and new drugs for patients with Lung malignancies and Head and Neck cancer. The goal is to develop novel therapies that are simple to administer as an outpatient and to pursue organ preservation.

Education and Training

  • Fellow In Oncology, Medicine, University of Texas Medical School at Houston, 1986 - 1987
  • Fellow In Hematology Oncology, Medicine, Louisiana State University at Shreveport, 1983 - 1985
  • Medical Resident, Medicine, Louisiana State University at Shreveport, 1980 - 1983
  • Intern In Surgery, Surgery, Charity Hospital, 1979 - 1980
  • M.D., Louisiana State University at Shreveport, 1979

Grants

Publications

Blumenschein, GR, Smit, EF, Planchard, D, Kim, D-W, Cadranel, J, De Pas, T, Dunphy, F, Udud, K, Ahn, M-J, Hanna, NH, Kim, J-H, Mazieres, J, Kim, S-W, Baas, P, Rappold, E, Redhu, S, Puski, A, Wu, FS, and Janne, PA. "A randomized phase II study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small-cell lung cancer (NSCLC)." Annals of Oncology 26, no. 5 (May 1, 2015): 894-901.

Full Text

Pfister, DG, Spencer, S, Brizel, DM, Burtness, B, Busse, PM, Caudell, JJ, Cmelak, AJ, Colevas, AD, Dunphy, F, Eisele, DW, Foote, RL, Gilbert, J, Gillison, ML, Haddad, RI, Haughey, BH, Hicks, WL, Hitchcock, YJ, Jimeno, A, Kies, MS, Lydiatt, WM, Maghami, E, McCaffrey, T, Mell, LK, Mittal, BB, Pinto, HA, Ridge, JA, Rodriguez, CP, Samant, S, Shah, JP, Weber, RS, Wolf, GT, Worden, F, Yom, SS, McMillian, N, and Hughes, M. "Head and neck cancers, version 1.2015 featured updates to the NCCN guidelines." JNCCN Journal of the National Comprehensive Cancer Network 13, no. 7 (January 1, 2015): 847-856.

Scholars@Duke

Jänne, PA, Ou, SH, Kim, DW, Oxnard, GR, Martins, R, Kris, MG, Dunphy, F, Nishio, M, O'Connell, J, Paweletz, C, Taylor, I, Zhang, H, Goldberg, Z, and Mok, T. "Dacomitinib as first-line treatment in patients with clinically or molecularly selected advanced non-small-cell lung cancer: a multicentre, open-label, phase 2 trial." The Lancet. Oncology 15, no. 13 (December 2014): 1433-1441.

PMID
25456362
Full Text

Pfister, DG, Spencer, S, Brizel, DM, Burtness, B, Busse, PM, Caudell, JJ, Cmelak, AJ, Colevas, AD, Dunphy, F, Eisele, DW, Gilbert, J, Gillison, ML, Haddad, RI, Haughey, BH, Hicks, WL, Hitchcock, YJ, Jimeno, A, Kies, MS, Lydiatt, WM, Maghami, E, Martins, R, McCaffrey, T, Mell, LK, Mittal, BB, Pinto, HA, Ridge, JA, Rodriguez, CP, Samant, S, Schuller, DE, Shah, JP, Weber, RS, Wolf, GT, Worden, F, Yom, SS, McMillian, NR, and Hughes, M. "Head and neck cancers, Version 2.2014. Clinical practice guidelines in oncology." Journal of the National Comprehensive Cancer Network : JNCCN 12, no. 10 (October 2014): 1454-1487.

PMID
25313184
Scholars@Duke

Jänne, PA, Ou, SHI, Kim, DW, Oxnard, GR, Martins, R, Kris, MG, Dunphy, F, Nishio, M, O'Connell, J, Paweletz, C, Taylor, I, Zhang, H, Goldberg, Z, and Mok, T. "Dacomitinib as first-line treatment in patients with clinically or molecularly selected advanced non-small-cell lung cancer: A multicentre, open-label, phase 2 trial." The Lancet Oncology 15, no. 13 (January 1, 2014): 1433-1441.

Full Text

Pfister, DG, Ang, KK, Brizel, DM, Burtness, BA, Busse, PM, Caudell, JJ, Cmelak, AJ, Colevas, AD, Dunphy, F, Eisele, DW, Gilbert, J, Gillison, ML, Haddad, RI, Haughey, BH, Hicks, WL, Hitchcock, YJ, Kies, MS, Lydiatt, WM, Maghami, E, Martins, R, McCaffrey, T, Mittal, BB, Pinto, HA, Ridge, JA, Samant, S, Schuller, DE, Shah, JP, Spencer, S, Weber, RS, Wolf, GT, Worden, F, Yom, SS, McMillian, NR, Hughes, M, and National Comprehensive Cancer Network, . "Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines." J Natl Compr Canc Netw 11, no. 8 (August 2013): 917-923.

PMID
23946171
Scholars@Duke

Shofer, Scott L., Frank Dunphy, Kamran Mahmood, Momen M. Wahidi, and David Yoo. “Endobronchial fiducial to guide stereotactic body radiotherapy.” J Bronchology Interv Pulmonol 20, no. 3 (July 2013): 274–75. https://doi.org/10.1097/LBR.0b013e31829dd690.

PMID
23857206
Full Text

Yoo, David S., John P. Kirkpatrick, Oana Craciunescu, Gloria Broadwater, Bercedis L. Peterson, Madeline D. Carroll, Robert Clough, et al. “Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer.” Clin Cancer Res 18, no. 5 (March 1, 2012): 1404–14. https://doi.org/10.1158/1078-0432.CCR-11-1982.

PMID
22253412
Full Text

Pfister, DG, Ang, KK, Brizel, DM, Burtness, B, Cmelak, AJ, Colevas, AD, Dunphy, F, Eisele, DW, Gilbert, J, Gillison, ML, Haddad, RI, Haughey, BH, Hicks, WL, Hitchcock, YJ, Kies, MS, Lydiatt, WM, Maghami, E, Martins, R, McCaffrey, T, Mittal, BB, Pinto, HA, Ridge, JA, Samant, S, Sanguineti, G, Schuller, DE, Shah, JP, Spencer, S, Trotti, A, Weber, RS, Wolf, G, Worden, F, and National Comprehensive Cancer Network, . "Mucosal melanoma of the head and neck." J Natl Compr Canc Netw 10, no. 3 (March 2012): 320-338.

PMID
22393194
Scholars@Duke

Dowell, JE, Dunphy, FR, Taub, RN, Gerber, DE, Ngov, L, Yan, J, Xie, Y, and Kindler, HL. "A multicenter phase II study of cisplatin, pemetrexed, and bevacizumab in patients with advanced malignant mesothelioma." Lung Cancer 77, no. 3 (2012): 567-571.

PMID
22770372
Full Text

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